| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GRK2 | BDKRB2 | Ser373 | SMGTLRTsISVERQI | phosphorylation down-regulates activity | 11517230 | SIGNOR-251445 |
| GRK5 | BDKRB2 | Ser375 | GTLRTSIsVERQIHK | phosphorylation down-regulates activity | 11517230 | SIGNOR-251209 |
| GRK2 | BDKRB2 | Ser375 | GTLRTSIsVERQIHK | phosphorylation down-regulates activity | 11517230 | SIGNOR-251446 |
| GRK3 | BDKRB2 | Ser366 | EPIQMENsMGTLRTS | phosphorylation down-regulates activity | 11517230 | SIGNOR-251460 |
| GRK3 | BDKRB2 | Ser373 | SMGTLRTsISVERQI | phosphorylation down-regulates activity | 11517230 | SIGNOR-249658 |
| SRC | BDKRB2 | Tyr347 | RKKSWEVyQGVCQKG | phosphorylation up-regulates | 16226010 | SIGNOR-141107 |
| GRK5 | BDKRB2 | Ser373 | SMGTLRTsISVERQI | phosphorylation down-regulates activity | 11517230 | SIGNOR-251208 |
| GRK6 | BDKRB2 | Ser375 | GTLRTSIsVERQIHK | phosphorylation down-regulates activity | 11517230 | SIGNOR-251206 |
| GRK6 | BDKRB2 | Ser366 | EPIQMENsMGTLRTS | phosphorylation down-regulates activity | 11517230 | SIGNOR-251207 |
| GRK4 | BDKRB2 | Ser375 | GTLRTSIsVERQIHK | phosphorylation down-regulates activity | 11517230 | SIGNOR-249674 |
| SRC | BDKRB2 | Tyr177 | GVRWAKLySLVIWGC | phosphorylation up-regulates | 16226010 | SIGNOR-141103 |
| GRK2 | BDKRB2 | Ser366 | EPIQMENsMGTLRTS | phosphorylation down-regulates activity | 11517230 | SIGNOR-251444 |
| GRK4 | BDKRB2 | Ser366 | EPIQMENsMGTLRTS | phosphorylation down-regulates activity | 11517230 | SIGNOR-247902 |
| GRK3 | BDKRB2 | Ser375 | GTLRTSIsVERQIHK | phosphorylation down-regulates activity | 11517230 | SIGNOR-251462 |
| PRKCD | BDKRB2 | Ser373 | SMGTLRTsISVERQI | phosphorylation down-regulates activity | 11517230 | SIGNOR-249108 |
| GRK6 | BDKRB2 | Ser373 | SMGTLRTsISVERQI | phosphorylation down-regulates activity | 11517230 | SIGNOR-251205 |
| GRK5 | BDKRB2 | Ser366 | EPIQMENsMGTLRTS | phosphorylation down-regulates activity | 11517230 | SIGNOR-251210 |
| GRK4 | BDKRB2 | Ser373 | SMGTLRTsISVERQI | phosphorylation down-regulates activity | 11517230 | SIGNOR-251193 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GRK2 | phosphorylation up-regulates → | BDKRB2 PSer373 | phosphorylation down-regulates ⊣ | BDKRB2 | 11517230 | SIGNOR-251445 |
| GRK5 | phosphorylation up-regulates → | BDKRB2 PSer375 | phosphorylation down-regulates ⊣ | BDKRB2 | 11517230 | SIGNOR-251209 |
| GRK2 | phosphorylation up-regulates → | BDKRB2 PSer375 | phosphorylation down-regulates ⊣ | BDKRB2 | 11517230 | SIGNOR-251446 |
| GRK3 | phosphorylation up-regulates → | BDKRB2 PSer366 | phosphorylation down-regulates ⊣ | BDKRB2 | 11517230 | SIGNOR-251460 |
| GRK3 | phosphorylation up-regulates → | BDKRB2 PSer373 | phosphorylation down-regulates ⊣ | BDKRB2 | 11517230 | SIGNOR-249658 |
| SRC | phosphorylation up-regulates → | BDKRB2 PTyr347 | phosphorylation up-regulates → | BDKRB2 | 16226010 | SIGNOR-141107 |
| GRK5 | phosphorylation up-regulates → | BDKRB2 PSer373 | phosphorylation down-regulates ⊣ | BDKRB2 | 11517230 | SIGNOR-251208 |
| GRK6 | phosphorylation up-regulates → | BDKRB2 PSer375 | phosphorylation down-regulates ⊣ | BDKRB2 | 11517230 | SIGNOR-251206 |
| GRK6 | phosphorylation up-regulates → | BDKRB2 PSer366 | phosphorylation down-regulates ⊣ | BDKRB2 | 11517230 | SIGNOR-251207 |
| GRK4 | phosphorylation up-regulates → | BDKRB2 PSer375 | phosphorylation down-regulates ⊣ | BDKRB2 | 11517230 | SIGNOR-249674 |
| SRC | phosphorylation up-regulates → | BDKRB2 PTyr177 | phosphorylation up-regulates → | BDKRB2 | 16226010 | SIGNOR-141103 |
| GRK2 | phosphorylation up-regulates → | BDKRB2 PSer366 | phosphorylation down-regulates ⊣ | BDKRB2 | 11517230 | SIGNOR-251444 |
| GRK4 | phosphorylation up-regulates → | BDKRB2 PSer366 | phosphorylation down-regulates ⊣ | BDKRB2 | 11517230 | SIGNOR-247902 |
| GRK3 | phosphorylation up-regulates → | BDKRB2 PSer375 | phosphorylation down-regulates ⊣ | BDKRB2 | 11517230 | SIGNOR-251462 |
| PRKCD | phosphorylation up-regulates → | BDKRB2 PSer373 | phosphorylation down-regulates ⊣ | BDKRB2 | 11517230 | SIGNOR-249108 |
| GRK6 | phosphorylation up-regulates → | BDKRB2 PSer373 | phosphorylation down-regulates ⊣ | BDKRB2 | 11517230 | SIGNOR-251205 |
| GRK5 | phosphorylation up-regulates → | BDKRB2 PSer366 | phosphorylation down-regulates ⊣ | BDKRB2 | 11517230 | SIGNOR-251210 |
| GRK4 | phosphorylation up-regulates → | BDKRB2 PSer373 | phosphorylation down-regulates ⊣ | BDKRB2 | 11517230 | SIGNOR-251193 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GRK2 | phosphorylation → down-regulates activity | BDKRB2 | SIGNOR-251445 |
| GRK5 | phosphorylation → down-regulates activity | BDKRB2 | SIGNOR-251209 |
| GRK2 | phosphorylation → down-regulates activity | BDKRB2 | SIGNOR-251446 |
| GRK3 | phosphorylation → down-regulates activity | BDKRB2 | SIGNOR-251460 |
| GRK3 | phosphorylation → down-regulates activity | BDKRB2 | SIGNOR-249658 |
| SRC | phosphorylation → up-regulates | BDKRB2 | SIGNOR-141107 |
| GRK5 | phosphorylation → down-regulates activity | BDKRB2 | SIGNOR-251208 |
| GRK6 | phosphorylation → down-regulates activity | BDKRB2 | SIGNOR-251206 |
| GRK6 | phosphorylation → down-regulates activity | BDKRB2 | SIGNOR-251207 |
| GRK4 | phosphorylation → down-regulates activity | BDKRB2 | SIGNOR-249674 |
| SRC | phosphorylation → up-regulates | BDKRB2 | SIGNOR-141103 |
| GRK2 | phosphorylation → down-regulates activity | BDKRB2 | SIGNOR-251444 |
| GRK4 | phosphorylation → down-regulates activity | BDKRB2 | SIGNOR-247902 |
| GRK3 | phosphorylation → down-regulates activity | BDKRB2 | SIGNOR-251462 |
| PRKCD | phosphorylation → down-regulates activity | BDKRB2 | SIGNOR-249108 |
| GRK6 | phosphorylation → down-regulates activity | BDKRB2 | SIGNOR-251205 |
| GRK5 | phosphorylation → down-regulates activity | BDKRB2 | SIGNOR-251210 |
| GRK4 | phosphorylation → down-regulates activity | BDKRB2 | SIGNOR-251193 |
