Entity Details

Name AXL
ID P30530
Role kinase
Enzymatic Domains
Ig-like C2-type 1 27-128
Ig-like C2-type 2 139-222
Fibronectin type-III 1 227-331
PROSITE-ProRule
Fibronectin type-III 2 336-428
PROSITE-ProRule
Protein kinase 536-807
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
AXLEGFRTyr1197STAENAEyLRVAPQSphosphorylation
up-regulates activity		25873175SIGNOR-279141
AXLERBB2–phosphorylation
down-regulates activity		20818175SIGNOR-280193
AXLYES1Tyr426RLIEDNEyTARQGAKphosphorylation
up-regulates activity		33941853SIGNOR-277555
AXLAXLTyr779ADCLDGLyALMSRCWphosphorylation
up-regulates activity		9178760SIGNOR-250591
AXLAXLTyr821QEPDEILyVNMDEGGphosphorylation
up-regulates activity		9178760SIGNOR-250592
AXLAXLTyr866EVHPAGRyVLCPSTTphosphorylation
up-regulates activity		9178760SIGNOR-250593
AXLNEDD9–phosphorylation
up-regulates activity		32681075SIGNOR-278905
AXLTNS2Tyr483GPLDGSPyAQVQRPPphosphorylation
up-regulates quantity		30419905SIGNOR-278471
AXLMLKLTyr376DRVKSTAyLSPQELEphosphorylation
up-regulates quantity by stabilization		31230815SIGNOR-274119
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
AXLphosphorylation
up-regulates
→
EGFR
PTyr1197		phosphorylation
up-regulates
→		EGFR25873175SIGNOR-279141
AXLphosphorylation
up-regulates
→
YES1
PTyr426		phosphorylation
up-regulates
→		YES133941853SIGNOR-277555
AXLphosphorylation
up-regulates
→
AXL
PTyr779		phosphorylation
up-regulates
→		AXL9178760SIGNOR-250591
AXLphosphorylation
up-regulates
→
AXL
PTyr821		phosphorylation
up-regulates
→		AXL9178760SIGNOR-250592
AXLphosphorylation
up-regulates
→
AXL
PTyr866		phosphorylation
up-regulates
→		AXL9178760SIGNOR-250593
AXLphosphorylation
up-regulates
→
TNS2
PTyr483		phosphorylation
up-regulates
→		TNS230419905SIGNOR-278471
AXLphosphorylation
up-regulates
→
MLKL
PTyr376		phosphorylation
up-regulates
→		MLKL31230815SIGNOR-274119
Regulator Mechanism/Effect Target SIGNOR-ID
AXLphosphorylation
→
up-regulates activity 		EGFRSIGNOR-279141
AXLphosphorylation
→
down-regulates activity 		ERBB2SIGNOR-280193
AXLphosphorylation
→
up-regulates activity 		YES1SIGNOR-277555
AXLphosphorylation
→
up-regulates activity 		AXLSIGNOR-250591
AXLphosphorylation
→
up-regulates activity 		AXLSIGNOR-250592
AXLphosphorylation
→
up-regulates activity 		AXLSIGNOR-250593
AXLphosphorylation
→
up-regulates activity 		NEDD9SIGNOR-278905
AXLphosphorylation
→
up-regulates quantity 		TNS2SIGNOR-278471
AXLphosphorylation
→
up-regulates quantity by stabilization 		MLKLSIGNOR-274119