Entity Details

Name AXL
ID P30530
Role substrate
Enzymatic Domains
Ig-like C2-type 1 27-128
Ig-like C2-type 2 139-222
Fibronectin type-III 1 227-331
PROSITE-ProRule
Fibronectin type-III 2 336-428
PROSITE-ProRule
Protein kinase 536-807
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
AXLAXLTyr821QEPDEILyVNMDEGGphosphorylation
up-regulates activity		9178760SIGNOR-250592
AXLAXLTyr866EVHPAGRyVLCPSTTphosphorylation
up-regulates activity		9178760SIGNOR-250593
EGFRAXLTyr779ADCLDGLyALMSRCWphosphorylation
up-regulates activity		27775700SIGNOR-279734
AXLAXLTyr779ADCLDGLyALMSRCWphosphorylation
up-regulates activity		9178760SIGNOR-250591
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
AXLphosphorylation
up-regulates
→
AXL
PTyr821		phosphorylation
up-regulates
→		AXL9178760SIGNOR-250592
AXLphosphorylation
up-regulates
→
AXL
PTyr866		phosphorylation
up-regulates
→		AXL9178760SIGNOR-250593
EGFRphosphorylation
up-regulates
→
AXL
PTyr779		phosphorylation
up-regulates
→		AXL27775700SIGNOR-279734
AXLphosphorylation
up-regulates
→
AXL
PTyr779		phosphorylation
up-regulates
→		AXL9178760SIGNOR-250591
Regulator Mechanism/Effect Target SIGNOR-ID
AXLphosphorylation
→
up-regulates activity 		AXLSIGNOR-250592
AXLphosphorylation
→
up-regulates activity 		AXLSIGNOR-250593
EGFRphosphorylation
→
up-regulates activity 		AXLSIGNOR-279734
AXLphosphorylation
→
up-regulates activity 		AXLSIGNOR-250591