| Name | CLIP1 |
| ID | P30622 |
| Role | substrate |
| Enzymatic Domains |
CAP-Gly 1 78-120 PROSITE-ProRule
CAP-Gly 2 232-274 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | CLIP1 | Ser195 | LTKTASEsISNLSEA | phosphorylation up-regulates | 20664522 | SIGNOR-167172 |
| CDK1 | CLIP1 | Thr287 | KIGFPSTtPAKAKAN | phosphorylation up-regulates activity | 19687009 | SIGNOR-275470 |
| MTOR | CLIP1 | – | phosphorylation up-regulates activity | 12742166 | SIGNOR-279231 | |
| LRRK1 | CLIP1 | Thr1430 | EMFGHWAtNCNDDET | phosphorylation up-regulates activity | 25413345 | SIGNOR-275469 |
| CyclinB/CDK1 | CLIP1 | Thr287 | KIGFPSTtPAKAKAN | phosphorylation up-regulates activity | 19687009 | SIGNOR-275471 |
| CSNK2A1 | CLIP1 | Ser1364 | DDLNNYDsDDQEKQS | phosphorylation up-regulates | 20664522 | SIGNOR-167168 |
| PRKCA | CLIP1 | Ser312 | ASLKRSPsASSLSSM | phosphorylation down-regulates | 20519438 | SIGNOR-165857 |
| PLK1 | CLIP1 | Ser312 | ASLKRSPsASSLSSM | phosphorylation down-regulates activity | 24451569 | SIGNOR-264575 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | phosphorylation up-regulates → | CLIP1 PSer195 | phosphorylation up-regulates → | CLIP1 | 20664522 | SIGNOR-167172 |
| CDK1 | phosphorylation up-regulates → | CLIP1 PThr287 | phosphorylation up-regulates → | CLIP1 | 19687009 | SIGNOR-275470 |
| LRRK1 | phosphorylation up-regulates → | CLIP1 PThr1430 | phosphorylation up-regulates → | CLIP1 | 25413345 | SIGNOR-275469 |
| CyclinB/CDK1 | phosphorylation up-regulates → | CLIP1 PThr287 | phosphorylation up-regulates → | CLIP1 | 19687009 | SIGNOR-275471 |
| CSNK2A1 | phosphorylation up-regulates → | CLIP1 PSer1364 | phosphorylation up-regulates → | CLIP1 | 20664522 | SIGNOR-167168 |
| PRKCA | phosphorylation up-regulates → | CLIP1 PSer312 | phosphorylation down-regulates ⊣ | CLIP1 | 20519438 | SIGNOR-165857 |
| PLK1 | phosphorylation up-regulates → | CLIP1 PSer312 | phosphorylation down-regulates ⊣ | CLIP1 | 24451569 | SIGNOR-264575 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PLK1 | phosphorylation → up-regulates | CLIP1 | SIGNOR-167172 |
| CDK1 | phosphorylation → up-regulates activity | CLIP1 | SIGNOR-275470 |
| MTOR | phosphorylation → up-regulates activity | CLIP1 | SIGNOR-279231 |
| LRRK1 | phosphorylation → up-regulates activity | CLIP1 | SIGNOR-275469 |
| CyclinB/CDK1 | phosphorylation → up-regulates activity | CLIP1 | SIGNOR-275471 |
| CSNK2A1 | phosphorylation → up-regulates | CLIP1 | SIGNOR-167168 |
| PRKCA | phosphorylation down-regulates | CLIP1 | SIGNOR-165857 |
| PLK1 | phosphorylation → down-regulates activity | CLIP1 | SIGNOR-264575 |