| Name | AKT2 |
| ID | P31751 |
| Role | kinase |
| Enzymatic Domains |
PH 5-108 PROSITE-ProRule
Protein kinase 152-409 PROSITE-ProRule
AGC-kinase C-terminal 410-481 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT2 | UPF1 | Thr151 | FCNGRGNtSGSHIVN | phosphorylation up-regulates activity | 35675814 | SIGNOR-277595 |
| AKT2 | RAF1 | – | phosphorylation down-regulates activity | 10576742 | SIGNOR-235678 | |
| AKT2 | SRSF5 | Ser86 | GRGRGRYsDRFSSRR | phosphorylation up-regulates activity | 15684423 | SIGNOR-262633 |
| AKT2 | FOXO1 | Thr24 | LPRPRSCtWPLPRPE | phosphorylation down-regulates activity | 10377430 | SIGNOR-68656 |
| AKT2 | ARNTL | – | phosphorylation down-regulates activity | 27576939 | SIGNOR-280177 | |
| AKT2 | ATF2 | – | phosphorylation up-regulates activity | 25890336 | SIGNOR-280178 | |
| AKT2 | TBC1D4 | – | phosphorylation down-regulates activity | 33810522 | SIGNOR-280179 | |
| AKT2 | mTORC1 | – | phosphorylation up-regulates activity | 17277771 | SIGNOR-235967 | |
| AKT2 | RALGAPA2 | Ser696 | TTVGRSFsLSWRSHP | phosphorylation down-regulates activity | 21148297 | SIGNOR-269798 |
| AKT2 | PPARGC1A | Ser571 | RMRSRSRsFSRHRSC | phosphorylation down-regulates | 17554339 | SIGNOR-155536 |
| AKT2 | PTPN1 | Ser50 | RNRYRDVsPFDHSRI | phosphorylation down-regulates activity | 11579209 | SIGNOR-235491 |
| AKT2 | AKT1S1 | Thr246 | LPRPRLNtSDFQKLK | phosphorylation down-regulates activity | 12524439 | SIGNOR-248046 |
| AKT2 | AKT1S1 | – | phosphorylation down-regulates | 17277771 | SIGNOR-152936 | |
| AKT2 | FOXO | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates activity | 19188143 | SIGNOR-252867 |
| AKT2 | FOXO1 | Ser256 | SPRRRAAsMDNNSKF | phosphorylation down-regulates activity | 10377430 | SIGNOR-68652 |
| AKT2 | PDK1 | Thr346 | APRPRVEtSRAVPLA | phosphorylation up-regulates activity | 27505672 | SIGNOR-277271 |
| AKT2 | ADARB1 | Thr553 | LQGERLLtMSCSDKI | phosphorylation down-regulates activity | 31095429 | SIGNOR-276196 |
| AKT2 | MDM2 | Ser166 | SSRRRAIsETEENSD | phosphorylation up-regulates quantity by stabilization | 11504915 | SIGNOR-109732 |
| AKT2 | PKP1 | Ser118 | EPDNRRFsSYSQMEN | phosphorylation up-regulates quantity by stabilization | 23444369 | SIGNOR-273486 |
| AKT2 | ADAR | Thr1033 | RLGERLRtMSCSDKI | phosphorylation down-regulates activity | 31095429 | SIGNOR-276192 |
| AKT2 | FOXO | Ser256 | SPRRRAAsMDNNSKF | phosphorylation down-regulates activity | 10377430 | SIGNOR-252871 |
| AKT2 | IKK-complex | – | phosphorylation up-regulates | 19609947 | SIGNOR-217463 | |
| AKT2 | ACLY | Ser455 | PAPSRTAsFSESRAD | phosphorylation unknown | 12107176 | SIGNOR-245263 |
| AKT2 | MDM2 | Ser186 | RQRKRHKsDSISLSF | phosphorylation up-regulates activity | 11504915 | SIGNOR-109736 |
| AKT2 | PKP1 | Thr179 | LGSKGQKtTQNRYSF | phosphorylation up-regulates quantity by stabilization | 23444369 | SIGNOR-273489 |
| AKT2 | AKT1S1 | – | phosphorylation down-regulates | 17386266 | SIGNOR-153931 | |
| AKT2 | FOXO | Thr32 | QSRPRSCtWPLPRPE | phosphorylation down-regulates activity | 16272144 | SIGNOR-252870 |
| AKT2 | YBX2 | Ser137 | NPRKFLRsVGDGETV | phosphorylation up-regulates quantity by stabilization | 37860762 | SIGNOR-277869 |
| AKT2 | STXBP4 | Ser99 | GAKLRLEsAWEIAFI | phosphorylation down-regulates activity | 15753124 | SIGNOR-262635 |
| AKT2 | CHUK | Thr23 | EMRERLGtGGFGNVC | phosphorylation up-regulates | 19609947 | SIGNOR-187010 |
| AKT2 | TSC2 | Ser939 | SFRARSTsLNERPKS | phosphorylation down-regulates | 12172553 | SIGNOR-91388 |
| AKT2 | POU5F1 | Thr235 | QARKRKRtSIENRVR | phosphorylation up-regulates quantity by stabilization | 23041284 | SIGNOR-242097 |
| AKT2 | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates activity | 19188143 | SIGNOR-236675 |
| AKT2 | PPARGC1A | Ser571 | RMRSRSRsFSRHRSC | phosphorylation down-regulates activity | 17554339 | SIGNOR-262626 |
| AKT2 | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249640 |
| AKT2 | HSF1 | Ser326 | SSVDTLLsPTALIDS | phosphorylation up-regulates activity | 35080342 | SIGNOR-279779 |
| AKT2 | FOXO4 | Thr32 | QSRPRSCtWPLPRPE | phosphorylation down-regulates activity | 11313479 | SIGNOR-251491 |
| AKT2 | STK4 | Thr387 | TMKRRDEtMQPAKPS | phosphorylation down-regulates | 23431053 | SIGNOR-201125 |
| AKT2 | MYO5A | Thr1650 | PTGLRKRtSSIADEG | phosphorylation up-regulates activity | 17515613 | SIGNOR-262632 |
| AKT2 | ATP7A | Ser1463 | IVNYSRAsINSLLSD | phosphorylation up-regulates quantity by stabilization | 29301787 | SIGNOR-272268 |
| AKT2 | CYCS | Tyr47 | KTGQAPGySYTAANK | phosphorylation down-regulates activity | 32781572 | SIGNOR-277236 |
| AKT2 | HSPB1 | Ser82 | RALSRQLsSGVSEIR | phosphorylation down-regulates | 19593530 | SIGNOR-186776 |
| AKT2 | TWIST1 | Ser42 | GGRKRRSsRRSAGGG | phosphorylation up-regulates activity | 26759241 | SIGNOR-279137 |
| AKT2 | PCBP1 | Ser43 | VKRIREEsGARINIS | phosphorylation down-regulates activity | 20154680 | SIGNOR-262625 |
| AKT2 | PKP1 | Thr189 | NRYSFYStCSGQKAI | phosphorylation up-regulates quantity by stabilization | 23444369 | SIGNOR-273493 |
| AKT2 | KHSRP | Ser193 | GLPERSVsLTGAPES | phosphorylation down-regulates | 17177604 | SIGNOR-151220 |
| AKT2 | CASP9 | Ser196 | KLRRRFSsLHFMVEV | phosphorylation down-regulates | 15004527 | SIGNOR-123243 |
| AKT2 | RALGAPA2 | Ser486 | SSWGRTYsFTSAMSR | phosphorylation down-regulates activity | 21148297 | SIGNOR-269797 |
| AKT2 | CTNNB1 | Ser552 | QDTQRRTsMGGTQQQ | phosphorylation up-regulates | 17287208 | SIGNOR-152958 |
| AKT2 | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249639 |
| AKT2 | TSC2 | Thr1462 | GLRPRGYtISDSAPS | phosphorylation down-regulates | 12172553 | SIGNOR-91392 |
| AKT2 | P300/PCAF | – | phosphorylation up-regulates | 17964260 | SIGNOR-217673 | |
| AKT2 | FOXO | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates activity | 19188143 | SIGNOR-252868 |
| AKT2 | CDKN1B | Thr157 | GIRKRPAtDDSSTQN | phosphorylation down-regulates | 12244303 | SIGNOR-93122 |
| AKT2 | EP300 | Ser1834 | MLRRRMAsMQRTGVV | phosphorylation up-regulates | 16926151 | SIGNOR-148987 |
| AKT2 | BRAF | Thr440 | EDRNRMKtLGRRDSS | phosphorylation down-regulates | 10869359 | SIGNOR-78689 |
| AKT2 | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 23552696 | SIGNOR-245420 |
| AKT2 | CASP9 | Ser196 | KLRRRFSsLHFMVEV | phosphorylation down-regulates | 9812896 | SIGNOR-61561 |
| AKT2 | RALGAPA2 | Thr715 | PMRFRSAtTSGAPGV | phosphorylation down-regulates activity | 21148297 | SIGNOR-269799 |
| AKT2 | ATP7A | Ser1466 | YSRASINsLLSDKRS | phosphorylation up-regulates quantity by stabilization | 29301787 | SIGNOR-272270 |
| AKT2 | TSC2 | Ser939 | SFRARSTsLNERPKS | phosphorylation down-regulates | 12150915 | SIGNOR-91041 |
| AKT2 | NOS3 | Ser615 | SYKIRFNsISCSDPL | phosphorylation up-regulates activity | 24379783 | SIGNOR-251624 |
| AKT2 | TSC2 | Ser939 | SFRARSTsLNERPKS | phosphorylation down-regulates | 19188143 | SIGNOR-183636 |
| AKT2 | PKP1 | Thr180 | GSKGQKTtQNRYSFY | phosphorylation up-regulates quantity by stabilization | 23444369 | SIGNOR-273485 |
| AKT2 | EP300 | – | phosphorylation up-regulates | 17964260 | SIGNOR-158627 | |
| AKT2 | BRAF | Ser428 | GPQRERKsSSSSEDR | phosphorylation down-regulates | 10869359 | SIGNOR-78685 |
| AKT2 | FOXO | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates activity | 19188143 | SIGNOR-252869 |
| AKT2 | XIAP | Ser87 | VGRHRKVsPNCRFIN | phosphorylation up-regulates | 14645242 | SIGNOR-119492 |
| AKT2 | BCL3 | Ser41 | KRPLRAPsPEPAAPR | phosphorylation up-regulates quantity by stabilization | 28689659 | SIGNOR-277359 |
| AKT2 | FOXO3 | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-249641 |
| AKT2 | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates activity | 19188143 | SIGNOR-236671 |
| AKT2 | ATP7A | Ser1424 | SYELPARsQIGQKSP | phosphorylation up-regulates quantity by stabilization | 29301787 | SIGNOR-272269 |
| AKT2 | PKP1 | Ser188 | QNRYSFYsTCSGQKA | phosphorylation up-regulates quantity by stabilization | 23444369 | SIGNOR-273490 |
| AKT2 | STK3 | Thr117 | IIRLRNKtLIEDEIA | phosphorylation down-regulates | 20231902 | SIGNOR-164302 |
| AKT2 | PPIF | Ser31 | LPAARACsKGSGDPS | phosphorylation up-regulates activity | 25650317 | SIGNOR-276875 |
| AKT2 | FOXO | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-252865 |
| AKT2 | C2CD5 | Ser197 | EARQRLIsLMSGELQ | phosphorylation up-regulates activity | 21907143 | SIGNOR-279585 |
| AKT2 | ANKRD2 | Ser99 | QERVRKTsLDLRREI | phosphorylation up-regulates | 21737686 | SIGNOR-236978 |
| AKT2 | FOXO | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-252863 |
| AKT2 | TSC | – | phosphorylation down-regulates activity | 19593385 | SIGNOR-235852 | |
| AKT2 | GSK3A | – | phosphorylation down-regulates | 16023596 | SIGNOR-138179 | |
| AKT2 | EZR | Thr567 | QGRDKYKtLRQIRQG | phosphorylation up-regulates | 15531580 | SIGNOR-130260 |
| AKT2 | FOXO | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates quantity by destabilization | 19951971 | SIGNOR-252864 |
| AKT2 | FOXO | Thr24 | LPRPRSCtWPLPRPE | phosphorylation down-regulates activity | 10377430 | SIGNOR-252872 |
| AKT2 | PKP1 | Ser174 | LRKGTLGsKGQKTTQ | phosphorylation up-regulates quantity by stabilization | 23444369 | SIGNOR-273492 |
| AKT2 | PKP1 | Ser191 | YSFYSTCsGQKAIKK | phosphorylation up-regulates quantity by stabilization | 23444369 | SIGNOR-273487 |
| AKT2 | FOXO4 | Thr32 | QSRPRSCtWPLPRPE | phosphorylation down-regulates activity | 16272144 | SIGNOR-248055 |
| AKT2 | FOXO | Thr32 | QSRPRSCtWPLPRPE | phosphorylation down-regulates activity | 11313479 | SIGNOR-252873 |
| AKT2 | PKP1 | Thr171 | RGTLRKGtLGSKGQK | phosphorylation up-regulates quantity by stabilization | 23444369 | SIGNOR-273488 |
| AKT2 | STK3/4 | – | phosphorylation down-regulates | 20231902 | SIGNOR-269937 | |
| AKT2 | HTRA2 | Ser212 | RVRVRLLsGDTYEAV | phosphorylation down-regulates | 17311912 | SIGNOR-153327 |
| AKT2 | BMI1 | Ser316 | ANRPRKSsVNGSSAT | phosphorylation up-regulates activity | 22505453 | SIGNOR-249582 |
| AKT2 | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates | 10949026 | SIGNOR-81110 |
| AKT2 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates | 9829964 | SIGNOR-62253 |
| AKT2 | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates | 10949026 | SIGNOR-81114 |
| AKT2 | BRAF | Ser364 | FGQRDRSsSAPNVHI | phosphorylation down-regulates | 10869359 | SIGNOR-78681 |
| AKT2 | PKP1 | Thr166 | LYCDPRGtLRKGTLG | phosphorylation up-regulates quantity by stabilization | 23444369 | SIGNOR-273491 |
| AKT2 | PKP1 | Ser185 | KTTQNRYsFYSTCSG | phosphorylation up-regulates quantity by stabilization | 23444369 | SIGNOR-273494 |
| AKT2 | TSC2 | Thr1462 | GLRPRGYtISDSAPS | phosphorylation down-regulates | 19188143 | SIGNOR-183640 |
| AKT2 | ESR1 | Ser167 | GGRERLAsTNDKGSM | phosphorylation up-regulates activity | 11139588 | SIGNOR-251490 |
| AKT2 | FOXO | – | phosphorylation down-regulates activity | 21620960 | SIGNOR-252866 | |
| AKT2 | mTORC1 | – | phosphorylation up-regulates activity | 17386266 | SIGNOR-236705 | |
| AKT2 | MAP3K5 | Ser83 | ATRGRGSsVGGGSRR | phosphorylation down-regulates activity | 12697749 | SIGNOR-100588 |
| AKT2 | TSC2 | Thr1462 | GLRPRGYtISDSAPS | phosphorylation down-regulates | 12150915 | SIGNOR-91045 |
| AKT2 | SH3RF1 | Ser304 | KNTKKRHsFTSLTMA | phosphorylation down-regulates | 17535800 | SIGNOR-155233 |
| AKT2 | FOXO4 | – | phosphorylation down-regulates activity | 21620960 | SIGNOR-233529 | |
| AKT2 | GSK3B | – | phosphorylation down-regulates activity | 16293724 | SIGNOR-235718 | |
| AKT2 | FOXO3 | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates activity | 19188143 | SIGNOR-235960 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT2 | phosphorylation up-regulates → | UPF1 PThr151 | phosphorylation up-regulates → | UPF1 | 35675814 | SIGNOR-277595 |
| AKT2 | phosphorylation up-regulates → | SRSF5 PSer86 | phosphorylation up-regulates → | SRSF5 | 15684423 | SIGNOR-262633 |
| AKT2 | phosphorylation up-regulates → | FOXO1 PThr24 | phosphorylation down-regulates ⊣ | FOXO1 | 10377430 | SIGNOR-68656 |
| AKT2 | phosphorylation up-regulates → | RALGAPA2 PSer696 | phosphorylation down-regulates ⊣ | RALGAPA2 | 21148297 | SIGNOR-269798 |
| AKT2 | phosphorylation up-regulates → | PPARGC1A PSer571 | phosphorylation down-regulates ⊣ | PPARGC1A | 17554339 | SIGNOR-155536 |
| AKT2 | phosphorylation up-regulates → | PTPN1 PSer50 | phosphorylation down-regulates ⊣ | PTPN1 | 11579209 | SIGNOR-235491 |
| AKT2 | phosphorylation up-regulates → | AKT1S1 PThr246 | phosphorylation down-regulates ⊣ | AKT1S1 | 12524439 | SIGNOR-248046 |
| AKT2 | phosphorylation up-regulates → | FOXO PSer253 | phosphorylation down-regulates ⊣ | FOXO | 19188143 | SIGNOR-252867 |
| AKT2 | phosphorylation up-regulates → | FOXO1 PSer256 | phosphorylation down-regulates ⊣ | FOXO1 | 10377430 | SIGNOR-68652 |
| AKT2 | phosphorylation up-regulates → | PDK1 PThr346 | phosphorylation up-regulates → | PDK1 | 27505672 | SIGNOR-277271 |
| AKT2 | phosphorylation up-regulates → | ADARB1 PThr553 | phosphorylation down-regulates ⊣ | ADARB1 | 31095429 | SIGNOR-276196 |
| AKT2 | phosphorylation up-regulates → | MDM2 PSer166 | phosphorylation up-regulates → | MDM2 | 11504915 | SIGNOR-109732 |
| AKT2 | phosphorylation up-regulates → | PKP1 PSer118 | phosphorylation up-regulates → | PKP1 | 23444369 | SIGNOR-273486 |
| AKT2 | phosphorylation up-regulates → | ADAR PThr1033 | phosphorylation down-regulates ⊣ | ADAR | 31095429 | SIGNOR-276192 |
| AKT2 | phosphorylation up-regulates → | FOXO PSer256 | phosphorylation down-regulates ⊣ | FOXO | 10377430 | SIGNOR-252871 |
| AKT2 | phosphorylation up-regulates → | ACLY PSer455 | phosphorylation down-regulates ⊣ | ACLY | 12107176 | SIGNOR-245263 |
| AKT2 | phosphorylation up-regulates → | MDM2 PSer186 | phosphorylation up-regulates → | MDM2 | 11504915 | SIGNOR-109736 |
| AKT2 | phosphorylation up-regulates → | PKP1 PThr179 | phosphorylation up-regulates → | PKP1 | 23444369 | SIGNOR-273489 |
| AKT2 | phosphorylation up-regulates → | FOXO PThr32 | phosphorylation down-regulates ⊣ | FOXO | 16272144 | SIGNOR-252870 |
| AKT2 | phosphorylation up-regulates → | YBX2 PSer137 | phosphorylation up-regulates → | YBX2 | 37860762 | SIGNOR-277869 |
| AKT2 | phosphorylation up-regulates → | STXBP4 PSer99 | phosphorylation down-regulates ⊣ | STXBP4 | 15753124 | SIGNOR-262635 |
| AKT2 | phosphorylation up-regulates → | CHUK PThr23 | phosphorylation up-regulates → | CHUK | 19609947 | SIGNOR-187010 |
| AKT2 | phosphorylation up-regulates → | TSC2 PSer939 | phosphorylation down-regulates ⊣ | TSC2 | 12172553 | SIGNOR-91388 |
| AKT2 | phosphorylation up-regulates → | POU5F1 PThr235 | phosphorylation up-regulates → | POU5F1 | 23041284 | SIGNOR-242097 |
| AKT2 | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-236675 |
| AKT2 | phosphorylation up-regulates → | PPARGC1A PSer571 | phosphorylation down-regulates ⊣ | PPARGC1A | 17554339 | SIGNOR-262626 |
| AKT2 | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249640 |
| AKT2 | phosphorylation up-regulates → | HSF1 PSer326 | phosphorylation up-regulates → | HSF1 | 35080342 | SIGNOR-279779 |
| AKT2 | phosphorylation up-regulates → | FOXO4 PThr32 | phosphorylation down-regulates ⊣ | FOXO4 | 11313479 | SIGNOR-251491 |
| AKT2 | phosphorylation up-regulates → | STK4 PThr387 | phosphorylation down-regulates ⊣ | STK4 | 23431053 | SIGNOR-201125 |
| AKT2 | phosphorylation up-regulates → | MYO5A PThr1650 | phosphorylation up-regulates → | MYO5A | 17515613 | SIGNOR-262632 |
| AKT2 | phosphorylation up-regulates → | ATP7A PSer1463 | phosphorylation up-regulates → | ATP7A | 29301787 | SIGNOR-272268 |
| AKT2 | phosphorylation up-regulates → | CYCS PTyr47 | phosphorylation down-regulates ⊣ | CYCS | 32781572 | SIGNOR-277236 |
| AKT2 | phosphorylation up-regulates → | HSPB1 PSer82 | phosphorylation down-regulates ⊣ | HSPB1 | 19593530 | SIGNOR-186776 |
| AKT2 | phosphorylation up-regulates → | TWIST1 PSer42 | phosphorylation up-regulates → | TWIST1 | 26759241 | SIGNOR-279137 |
| AKT2 | phosphorylation up-regulates → | PCBP1 PSer43 | phosphorylation down-regulates ⊣ | PCBP1 | 20154680 | SIGNOR-262625 |
| AKT2 | phosphorylation up-regulates → | PKP1 PThr189 | phosphorylation up-regulates → | PKP1 | 23444369 | SIGNOR-273493 |
| AKT2 | phosphorylation up-regulates → | KHSRP PSer193 | phosphorylation down-regulates ⊣ | KHSRP | 17177604 | SIGNOR-151220 |
| AKT2 | phosphorylation up-regulates → | CASP9 PSer196 | phosphorylation down-regulates ⊣ | CASP9 | 15004527 | SIGNOR-123243 |
| AKT2 | phosphorylation up-regulates → | RALGAPA2 PSer486 | phosphorylation down-regulates ⊣ | RALGAPA2 | 21148297 | SIGNOR-269797 |
| AKT2 | phosphorylation up-regulates → | CTNNB1 PSer552 | phosphorylation up-regulates → | CTNNB1 | 17287208 | SIGNOR-152958 |
| AKT2 | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249639 |
| AKT2 | phosphorylation up-regulates → | TSC2 PThr1462 | phosphorylation down-regulates ⊣ | TSC2 | 12172553 | SIGNOR-91392 |
| AKT2 | phosphorylation up-regulates → | FOXO PSer315 | phosphorylation down-regulates ⊣ | FOXO | 19188143 | SIGNOR-252868 |
| AKT2 | phosphorylation up-regulates → | CDKN1B PThr157 | phosphorylation down-regulates ⊣ | CDKN1B | 12244303 | SIGNOR-93122 |
| AKT2 | phosphorylation up-regulates → | EP300 PSer1834 | phosphorylation up-regulates → | EP300 | 16926151 | SIGNOR-148987 |
| AKT2 | phosphorylation up-regulates → | BRAF PThr440 | phosphorylation down-regulates ⊣ | BRAF | 10869359 | SIGNOR-78689 |
| AKT2 | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 23552696 | SIGNOR-245420 |
| AKT2 | phosphorylation up-regulates → | CASP9 PSer196 | phosphorylation down-regulates ⊣ | CASP9 | 9812896 | SIGNOR-61561 |
| AKT2 | phosphorylation up-regulates → | RALGAPA2 PThr715 | phosphorylation down-regulates ⊣ | RALGAPA2 | 21148297 | SIGNOR-269799 |
| AKT2 | phosphorylation up-regulates → | ATP7A PSer1466 | phosphorylation up-regulates → | ATP7A | 29301787 | SIGNOR-272270 |
| AKT2 | phosphorylation up-regulates → | TSC2 PSer939 | phosphorylation down-regulates ⊣ | TSC2 | 12150915 | SIGNOR-91041 |
| AKT2 | phosphorylation up-regulates → | NOS3 PSer615 | phosphorylation up-regulates → | NOS3 | 24379783 | SIGNOR-251624 |
| AKT2 | phosphorylation up-regulates → | TSC2 PSer939 | phosphorylation down-regulates ⊣ | TSC2 | 19188143 | SIGNOR-183636 |
| AKT2 | phosphorylation up-regulates → | PKP1 PThr180 | phosphorylation up-regulates → | PKP1 | 23444369 | SIGNOR-273485 |
| AKT2 | phosphorylation up-regulates → | BRAF PSer428 | phosphorylation down-regulates ⊣ | BRAF | 10869359 | SIGNOR-78685 |
| AKT2 | phosphorylation up-regulates → | FOXO PThr32 | phosphorylation down-regulates ⊣ | FOXO | 19188143 | SIGNOR-252869 |
| AKT2 | phosphorylation up-regulates → | XIAP PSer87 | phosphorylation up-regulates → | XIAP | 14645242 | SIGNOR-119492 |
| AKT2 | phosphorylation up-regulates → | BCL3 PSer41 | phosphorylation up-regulates → | BCL3 | 28689659 | SIGNOR-277359 |
| AKT2 | phosphorylation up-regulates → | FOXO3 PSer315 | phosphorylation down-regulates ⊣ | FOXO3 | 19951971 | SIGNOR-249641 |
| AKT2 | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-236671 |
| AKT2 | phosphorylation up-regulates → | ATP7A PSer1424 | phosphorylation up-regulates → | ATP7A | 29301787 | SIGNOR-272269 |
| AKT2 | phosphorylation up-regulates → | PKP1 PSer188 | phosphorylation up-regulates → | PKP1 | 23444369 | SIGNOR-273490 |
| AKT2 | phosphorylation up-regulates → | STK3 PThr117 | phosphorylation down-regulates ⊣ | STK3 | 20231902 | SIGNOR-164302 |
| AKT2 | phosphorylation up-regulates → | PPIF PSer31 | phosphorylation up-regulates → | PPIF | 25650317 | SIGNOR-276875 |
| AKT2 | phosphorylation up-regulates → | FOXO PThr32 | phosphorylation down-regulates ⊣ | FOXO | 19951971 | SIGNOR-252865 |
| AKT2 | phosphorylation up-regulates → | C2CD5 PSer197 | phosphorylation up-regulates → | C2CD5 | 21907143 | SIGNOR-279585 |
| AKT2 | phosphorylation up-regulates → | ANKRD2 PSer99 | phosphorylation up-regulates → | ANKRD2 | 21737686 | SIGNOR-236978 |
| AKT2 | phosphorylation up-regulates → | FOXO PSer253 | phosphorylation down-regulates ⊣ | FOXO | 19951971 | SIGNOR-252863 |
| AKT2 | phosphorylation up-regulates → | EZR PThr567 | phosphorylation up-regulates → | EZR | 15531580 | SIGNOR-130260 |
| AKT2 | phosphorylation up-regulates → | FOXO PSer315 | phosphorylation down-regulates ⊣ | FOXO | 19951971 | SIGNOR-252864 |
| AKT2 | phosphorylation up-regulates → | FOXO PThr24 | phosphorylation down-regulates ⊣ | FOXO | 10377430 | SIGNOR-252872 |
| AKT2 | phosphorylation up-regulates → | PKP1 PSer174 | phosphorylation up-regulates → | PKP1 | 23444369 | SIGNOR-273492 |
| AKT2 | phosphorylation up-regulates → | PKP1 PSer191 | phosphorylation up-regulates → | PKP1 | 23444369 | SIGNOR-273487 |
| AKT2 | phosphorylation up-regulates → | FOXO4 PThr32 | phosphorylation down-regulates ⊣ | FOXO4 | 16272144 | SIGNOR-248055 |
| AKT2 | phosphorylation up-regulates → | FOXO PThr32 | phosphorylation down-regulates ⊣ | FOXO | 11313479 | SIGNOR-252873 |
| AKT2 | phosphorylation up-regulates → | PKP1 PThr171 | phosphorylation up-regulates → | PKP1 | 23444369 | SIGNOR-273488 |
| AKT2 | phosphorylation up-regulates → | HTRA2 PSer212 | phosphorylation down-regulates ⊣ | HTRA2 | 17311912 | SIGNOR-153327 |
| AKT2 | phosphorylation up-regulates → | BMI1 PSer316 | phosphorylation up-regulates → | BMI1 | 22505453 | SIGNOR-249582 |
| AKT2 | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-81110 |
| AKT2 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 9829964 | SIGNOR-62253 |
| AKT2 | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 10949026 | SIGNOR-81114 |
| AKT2 | phosphorylation up-regulates → | BRAF PSer364 | phosphorylation down-regulates ⊣ | BRAF | 10869359 | SIGNOR-78681 |
| AKT2 | phosphorylation up-regulates → | PKP1 PThr166 | phosphorylation up-regulates → | PKP1 | 23444369 | SIGNOR-273491 |
| AKT2 | phosphorylation up-regulates → | PKP1 PSer185 | phosphorylation up-regulates → | PKP1 | 23444369 | SIGNOR-273494 |
| AKT2 | phosphorylation up-regulates → | TSC2 PThr1462 | phosphorylation down-regulates ⊣ | TSC2 | 19188143 | SIGNOR-183640 |
| AKT2 | phosphorylation up-regulates → | ESR1 PSer167 | phosphorylation up-regulates → | ESR1 | 11139588 | SIGNOR-251490 |
| AKT2 | phosphorylation up-regulates → | MAP3K5 PSer83 | phosphorylation down-regulates ⊣ | MAP3K5 | 12697749 | SIGNOR-100588 |
| AKT2 | phosphorylation up-regulates → | TSC2 PThr1462 | phosphorylation down-regulates ⊣ | TSC2 | 12150915 | SIGNOR-91045 |
| AKT2 | phosphorylation up-regulates → | SH3RF1 PSer304 | phosphorylation down-regulates ⊣ | SH3RF1 | 17535800 | SIGNOR-155233 |
| AKT2 | phosphorylation up-regulates → | FOXO3 PSer315 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-235960 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT2 | phosphorylation → up-regulates activity | UPF1 | SIGNOR-277595 |
| AKT2 | phosphorylation → down-regulates activity | RAF1 | SIGNOR-235678 |
| AKT2 | phosphorylation → up-regulates activity | SRSF5 | SIGNOR-262633 |
| AKT2 | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-68656 |
| AKT2 | phosphorylation → down-regulates activity | ARNTL | SIGNOR-280177 |
| AKT2 | phosphorylation → up-regulates activity | ATF2 | SIGNOR-280178 |
| AKT2 | phosphorylation → down-regulates activity | TBC1D4 | SIGNOR-280179 |
| AKT2 | phosphorylation → up-regulates activity | mTORC1 | SIGNOR-235967 |
| AKT2 | phosphorylation → down-regulates activity | RALGAPA2 | SIGNOR-269798 |
| AKT2 | phosphorylation down-regulates | PPARGC1A | SIGNOR-155536 |
| AKT2 | phosphorylation → down-regulates activity | PTPN1 | SIGNOR-235491 |
| AKT2 | phosphorylation → down-regulates activity | AKT1S1 | SIGNOR-248046 |
| AKT2 | phosphorylation down-regulates | AKT1S1 | SIGNOR-152936 |
| AKT2 | phosphorylation → down-regulates activity | FOXO | SIGNOR-252867 |
| AKT2 | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-68652 |
| AKT2 | phosphorylation → up-regulates activity | PDK1 | SIGNOR-277271 |
| AKT2 | phosphorylation → down-regulates activity | ADARB1 | SIGNOR-276196 |
| AKT2 | phosphorylation → up-regulates quantity by stabilization | MDM2 | SIGNOR-109732 |
| AKT2 | phosphorylation → up-regulates quantity by stabilization | PKP1 | SIGNOR-273486 |
| AKT2 | phosphorylation → down-regulates activity | ADAR | SIGNOR-276192 |
| AKT2 | phosphorylation → down-regulates activity | FOXO | SIGNOR-252871 |
| AKT2 | phosphorylation → up-regulates | IKK-complex | SIGNOR-217463 |
| AKT2 | phosphorylation → unknown | ACLY | SIGNOR-245263 |
| AKT2 | phosphorylation → up-regulates activity | MDM2 | SIGNOR-109736 |
| AKT2 | phosphorylation → up-regulates quantity by stabilization | PKP1 | SIGNOR-273489 |
| AKT2 | phosphorylation down-regulates | AKT1S1 | SIGNOR-153931 |
| AKT2 | phosphorylation → down-regulates activity | FOXO | SIGNOR-252870 |
| AKT2 | phosphorylation → up-regulates quantity by stabilization | YBX2 | SIGNOR-277869 |
| AKT2 | phosphorylation → down-regulates activity | STXBP4 | SIGNOR-262635 |
| AKT2 | phosphorylation → up-regulates | CHUK | SIGNOR-187010 |
| AKT2 | phosphorylation down-regulates | TSC2 | SIGNOR-91388 |
| AKT2 | phosphorylation → up-regulates quantity by stabilization | POU5F1 | SIGNOR-242097 |
| AKT2 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-236675 |
| AKT2 | phosphorylation → down-regulates activity | PPARGC1A | SIGNOR-262626 |
| AKT2 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249640 |
| AKT2 | phosphorylation → up-regulates activity | HSF1 | SIGNOR-279779 |
| AKT2 | phosphorylation → down-regulates activity | FOXO4 | SIGNOR-251491 |
| AKT2 | phosphorylation down-regulates | STK4 | SIGNOR-201125 |
| AKT2 | phosphorylation → up-regulates activity | MYO5A | SIGNOR-262632 |
| AKT2 | phosphorylation → up-regulates quantity by stabilization | ATP7A | SIGNOR-272268 |
| AKT2 | phosphorylation → down-regulates activity | CYCS | SIGNOR-277236 |
| AKT2 | phosphorylation down-regulates | HSPB1 | SIGNOR-186776 |
| AKT2 | phosphorylation → up-regulates activity | TWIST1 | SIGNOR-279137 |
| AKT2 | phosphorylation → down-regulates activity | PCBP1 | SIGNOR-262625 |
| AKT2 | phosphorylation → up-regulates quantity by stabilization | PKP1 | SIGNOR-273493 |
| AKT2 | phosphorylation down-regulates | KHSRP | SIGNOR-151220 |
| AKT2 | phosphorylation down-regulates | CASP9 | SIGNOR-123243 |
| AKT2 | phosphorylation → down-regulates activity | RALGAPA2 | SIGNOR-269797 |
| AKT2 | phosphorylation → up-regulates | CTNNB1 | SIGNOR-152958 |
| AKT2 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249639 |
| AKT2 | phosphorylation down-regulates | TSC2 | SIGNOR-91392 |
| AKT2 | phosphorylation → up-regulates | P300/PCAF | SIGNOR-217673 |
| AKT2 | phosphorylation → down-regulates activity | FOXO | SIGNOR-252868 |
| AKT2 | phosphorylation down-regulates | CDKN1B | SIGNOR-93122 |
| AKT2 | phosphorylation → up-regulates | EP300 | SIGNOR-148987 |
| AKT2 | phosphorylation down-regulates | BRAF | SIGNOR-78689 |
| AKT2 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-245420 |
| AKT2 | phosphorylation down-regulates | CASP9 | SIGNOR-61561 |
| AKT2 | phosphorylation → down-regulates activity | RALGAPA2 | SIGNOR-269799 |
| AKT2 | phosphorylation → up-regulates quantity by stabilization | ATP7A | SIGNOR-272270 |
| AKT2 | phosphorylation down-regulates | TSC2 | SIGNOR-91041 |
| AKT2 | phosphorylation → up-regulates activity | NOS3 | SIGNOR-251624 |
| AKT2 | phosphorylation down-regulates | TSC2 | SIGNOR-183636 |
| AKT2 | phosphorylation → up-regulates quantity by stabilization | PKP1 | SIGNOR-273485 |
| AKT2 | phosphorylation → up-regulates | EP300 | SIGNOR-158627 |
| AKT2 | phosphorylation down-regulates | BRAF | SIGNOR-78685 |
| AKT2 | phosphorylation → down-regulates activity | FOXO | SIGNOR-252869 |
| AKT2 | phosphorylation → up-regulates | XIAP | SIGNOR-119492 |
| AKT2 | phosphorylation → up-regulates quantity by stabilization | BCL3 | SIGNOR-277359 |
| AKT2 | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-249641 |
| AKT2 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-236671 |
| AKT2 | phosphorylation → up-regulates quantity by stabilization | ATP7A | SIGNOR-272269 |
| AKT2 | phosphorylation → up-regulates quantity by stabilization | PKP1 | SIGNOR-273490 |
| AKT2 | phosphorylation down-regulates | STK3 | SIGNOR-164302 |
| AKT2 | phosphorylation → up-regulates activity | PPIF | SIGNOR-276875 |
| AKT2 | phosphorylation down-regulates quantity by destabilization | FOXO | SIGNOR-252865 |
| AKT2 | phosphorylation → up-regulates activity | C2CD5 | SIGNOR-279585 |
| AKT2 | phosphorylation → up-regulates | ANKRD2 | SIGNOR-236978 |
| AKT2 | phosphorylation down-regulates quantity by destabilization | FOXO | SIGNOR-252863 |
| AKT2 | phosphorylation → down-regulates activity | TSC | SIGNOR-235852 |
| AKT2 | phosphorylation down-regulates | GSK3A | SIGNOR-138179 |
| AKT2 | phosphorylation → up-regulates | EZR | SIGNOR-130260 |
| AKT2 | phosphorylation down-regulates quantity by destabilization | FOXO | SIGNOR-252864 |
| AKT2 | phosphorylation → down-regulates activity | FOXO | SIGNOR-252872 |
| AKT2 | phosphorylation → up-regulates quantity by stabilization | PKP1 | SIGNOR-273492 |
| AKT2 | phosphorylation → up-regulates quantity by stabilization | PKP1 | SIGNOR-273487 |
| AKT2 | phosphorylation → down-regulates activity | FOXO4 | SIGNOR-248055 |
| AKT2 | phosphorylation → down-regulates activity | FOXO | SIGNOR-252873 |
| AKT2 | phosphorylation → up-regulates quantity by stabilization | PKP1 | SIGNOR-273488 |
| AKT2 | phosphorylation down-regulates | STK3/4 | SIGNOR-269937 |
| AKT2 | phosphorylation down-regulates | HTRA2 | SIGNOR-153327 |
| AKT2 | phosphorylation → up-regulates activity | BMI1 | SIGNOR-249582 |
| AKT2 | phosphorylation down-regulates | BAD | SIGNOR-81110 |
| AKT2 | phosphorylation → up-regulates | CREB1 | SIGNOR-62253 |
| AKT2 | phosphorylation down-regulates | BAD | SIGNOR-81114 |
| AKT2 | phosphorylation down-regulates | BRAF | SIGNOR-78681 |
| AKT2 | phosphorylation → up-regulates quantity by stabilization | PKP1 | SIGNOR-273491 |
| AKT2 | phosphorylation → up-regulates quantity by stabilization | PKP1 | SIGNOR-273494 |
| AKT2 | phosphorylation down-regulates | TSC2 | SIGNOR-183640 |
| AKT2 | phosphorylation → up-regulates activity | ESR1 | SIGNOR-251490 |
| AKT2 | phosphorylation → down-regulates activity | FOXO | SIGNOR-252866 |
| AKT2 | phosphorylation → up-regulates activity | mTORC1 | SIGNOR-236705 |
| AKT2 | phosphorylation → down-regulates activity | MAP3K5 | SIGNOR-100588 |
| AKT2 | phosphorylation down-regulates | TSC2 | SIGNOR-91045 |
| AKT2 | phosphorylation down-regulates | SH3RF1 | SIGNOR-155233 |
| AKT2 | phosphorylation → down-regulates activity | FOXO4 | SIGNOR-233529 |
| AKT2 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-235718 |
| AKT2 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-235960 |