| Name | AKT2 |
| ID | P31751 |
| Role | substrate |
| Enzymatic Domains |
PH 5-108 PROSITE-ProRule
Protein kinase 152-409 PROSITE-ProRule
AGC-kinase C-terminal 410-481 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PDPK1 | AKT2 | Ser474 | RTHFPQFsYSASIRE | phosphorylation up-regulates activity | 15743829 | SIGNOR-134481 |
| PPP2CA | AKT2 | Ser474 | RTHFPQFsYSASIRE | dephosphorylation down-regulates activity | 18160256 | SIGNOR-248632 |
| PHLPP2 | AKT2 | Ser474 | RTHFPQFsYSASIRE | dephosphorylation down-regulates activity | 19261608 | SIGNOR-248729 |
| PHLPP1 | AKT2 | Ser474 | RTHFPQFsYSASIRE | dephosphorylation down-regulates activity | 19261608 | SIGNOR-248328 |
| PPP2CA | AKT2 | Thr309 | SDGATMKtFCGTPEY | dephosphorylation down-regulates activity | 18160256 | SIGNOR-248630 |
| PPP2CA | AKT2 | Thr309 | SDGATMKtFCGTPEY | dephosphorylation down-regulates activity | 15367694 | SIGNOR-248633 |
| PPP2CA | AKT2 | Ser474 | RTHFPQFsYSASIRE | dephosphorylation down-regulates activity | 15367694 | SIGNOR-248631 |
| PPP2CB | AKT2 | – | dephosphorylation down-regulates | 8650155 | SIGNOR-42123 | |
| MAPK14 | AKT2 | Ser474 | RTHFPQFsYSASIRE | phosphorylation up-regulates activity | 12181443 | SIGNOR-91408 |
| PRKCZ | AKT2 | Thr309 | SDGATMKtFCGTPEY | phosphorylation up-regulates activity | 9512493 | SIGNOR-248997 |
| ILK | AKT2 | Ser474 | RTHFPQFsYSASIRE | phosphorylation up-regulates activity | 19460343 | SIGNOR-279055 |
| ACP1 | AKT2 | Ser474 | RTHFPQFsYSASIRE | dephosphorylation down-regulates activity | 17353188 | SIGNOR-248456 |
| PHLPP1 | AKT2 | – | dephosphorylation down-regulates | 17386267 | SIGNOR-153935 | |
| PDPK1 | AKT2 | Thr309 | SDGATMKtFCGTPEY | phosphorylation up-regulates activity | 9512493 | SIGNOR-236785 |
| PDPK1 | AKT2 | Thr309 | SDGATMKtFCGTPEY | phosphorylation up-regulates activity | 15743829 | SIGNOR-134485 |
| PHLPP1 | AKT2 | – | dephosphorylation unknown | 15808505 | SIGNOR-135008 | |
| PDK1 | AKT2 | – | phosphorylation up-regulates activity | 15068796 | SIGNOR-279248 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PDPK1 | phosphorylation up-regulates → | AKT2 PSer474 | phosphorylation up-regulates → | AKT2 | 15743829 | SIGNOR-134481 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT2 PSer474 | dephosphorylation up-regulates → | AKT2 | 18160256 | SIGNOR-248632 |
| PHLPP2 | dephosphorylation down-regulates ⊣ | AKT2 PSer474 | dephosphorylation up-regulates → | AKT2 | 19261608 | SIGNOR-248729 |
| PHLPP1 | dephosphorylation down-regulates ⊣ | AKT2 PSer474 | dephosphorylation up-regulates → | AKT2 | 19261608 | SIGNOR-248328 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT2 PThr309 | dephosphorylation up-regulates → | AKT2 | 18160256 | SIGNOR-248630 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT2 PThr309 | dephosphorylation up-regulates → | AKT2 | 15367694 | SIGNOR-248633 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT2 PSer474 | dephosphorylation up-regulates → | AKT2 | 15367694 | SIGNOR-248631 |
| MAPK14 | phosphorylation up-regulates → | AKT2 PSer474 | phosphorylation up-regulates → | AKT2 | 12181443 | SIGNOR-91408 |
| PRKCZ | phosphorylation up-regulates → | AKT2 PThr309 | phosphorylation up-regulates → | AKT2 | 9512493 | SIGNOR-248997 |
| ILK | phosphorylation up-regulates → | AKT2 PSer474 | phosphorylation up-regulates → | AKT2 | 19460343 | SIGNOR-279055 |
| ACP1 | dephosphorylation down-regulates ⊣ | AKT2 PSer474 | dephosphorylation up-regulates → | AKT2 | 17353188 | SIGNOR-248456 |
| PDPK1 | phosphorylation up-regulates → | AKT2 PThr309 | phosphorylation up-regulates → | AKT2 | 9512493 | SIGNOR-236785 |
| PDPK1 | phosphorylation up-regulates → | AKT2 PThr309 | phosphorylation up-regulates → | AKT2 | 15743829 | SIGNOR-134485 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PDPK1 | phosphorylation → up-regulates activity | AKT2 | SIGNOR-134481 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT2 | SIGNOR-248632 |
| PHLPP2 | dephosphorylation → down-regulates activity | AKT2 | SIGNOR-248729 |
| PHLPP1 | dephosphorylation → down-regulates activity | AKT2 | SIGNOR-248328 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT2 | SIGNOR-248630 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT2 | SIGNOR-248633 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT2 | SIGNOR-248631 |
| PPP2CB | dephosphorylation down-regulates | AKT2 | SIGNOR-42123 |
| MAPK14 | phosphorylation → up-regulates activity | AKT2 | SIGNOR-91408 |
| PRKCZ | phosphorylation → up-regulates activity | AKT2 | SIGNOR-248997 |
| ILK | phosphorylation → up-regulates activity | AKT2 | SIGNOR-279055 |
| ACP1 | dephosphorylation → down-regulates activity | AKT2 | SIGNOR-248456 |
| PHLPP1 | dephosphorylation down-regulates | AKT2 | SIGNOR-153935 |
| PDPK1 | phosphorylation → up-regulates activity | AKT2 | SIGNOR-236785 |
| PDPK1 | phosphorylation → up-regulates activity | AKT2 | SIGNOR-134485 |
| PHLPP1 | dephosphorylation → unknown | AKT2 | SIGNOR-135008 |
| PDK1 | phosphorylation → up-regulates activity | AKT2 | SIGNOR-279248 |