| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CA | AKT2 | Ser474 | RTHFPQFsYSASIRE | dephosphorylation down-regulates activity | 18160256 | SIGNOR-248632 |
| PHLPP1 | AKT2 | Ser474 | RTHFPQFsYSASIRE | dephosphorylation down-regulates activity | 19261608 | SIGNOR-248328 |
| PPP2CA | AKT2 | Ser474 | RTHFPQFsYSASIRE | dephosphorylation down-regulates activity | 15367694 | SIGNOR-248631 |
| PDPK1 | AKT2 | Ser474 | RTHFPQFsYSASIRE | phosphorylation up-regulates activity | 15743829 | SIGNOR-134481 |
| PHLPP2 | AKT2 | Ser474 | RTHFPQFsYSASIRE | dephosphorylation down-regulates activity | 19261608 | SIGNOR-248729 |
| ILK | AKT2 | Ser474 | RTHFPQFsYSASIRE | phosphorylation up-regulates activity | 19460343 | SIGNOR-279055 |
| MAPK14 | AKT2 | Ser474 | RTHFPQFsYSASIRE | phosphorylation up-regulates activity | 12181443 | SIGNOR-91408 |
| ACP1 | AKT2 | Ser474 | RTHFPQFsYSASIRE | dephosphorylation down-regulates activity | 17353188 | SIGNOR-248456 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT2 PSer474 | dephosphorylation up-regulates → | AKT2 | 18160256 | SIGNOR-248632 |
| PHLPP1 | dephosphorylation down-regulates ⊣ | AKT2 PSer474 | dephosphorylation up-regulates → | AKT2 | 19261608 | SIGNOR-248328 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT2 PSer474 | dephosphorylation up-regulates → | AKT2 | 15367694 | SIGNOR-248631 |
| PDPK1 | phosphorylation up-regulates → | AKT2 PSer474 | phosphorylation up-regulates → | AKT2 | 15743829 | SIGNOR-134481 |
| PHLPP2 | dephosphorylation down-regulates ⊣ | AKT2 PSer474 | dephosphorylation up-regulates → | AKT2 | 19261608 | SIGNOR-248729 |
| ILK | phosphorylation up-regulates → | AKT2 PSer474 | phosphorylation up-regulates → | AKT2 | 19460343 | SIGNOR-279055 |
| MAPK14 | phosphorylation up-regulates → | AKT2 PSer474 | phosphorylation up-regulates → | AKT2 | 12181443 | SIGNOR-91408 |
| ACP1 | dephosphorylation down-regulates ⊣ | AKT2 PSer474 | dephosphorylation up-regulates → | AKT2 | 17353188 | SIGNOR-248456 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP2CA | dephosphorylation → down-regulates activity | AKT2 | SIGNOR-248632 |
| PHLPP1 | dephosphorylation → down-regulates activity | AKT2 | SIGNOR-248328 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT2 | SIGNOR-248631 |
| PDPK1 | phosphorylation → up-regulates activity | AKT2 | SIGNOR-134481 |
| PHLPP2 | dephosphorylation → down-regulates activity | AKT2 | SIGNOR-248729 |
| ILK | phosphorylation → up-regulates activity | AKT2 | SIGNOR-279055 |
| MAPK14 | phosphorylation → up-regulates activity | AKT2 | SIGNOR-91408 |
| ACP1 | dephosphorylation → down-regulates activity | AKT2 | SIGNOR-248456 |
