| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | YWHAB | Ser186 | FYYEILNsPEKACSL | phosphorylation down-regulates | 15696159 | SIGNOR-133875 |
| PRKCZ | YWHAB | Thr143 | SGDNKQTtVSNSQQA | phosphorylation down-regulates activity | 10620507 | SIGNOR-249035 |
| PRKCD | YWHAB | Ser60 | VVGARRSsWRVISSI | phosphorylation down-regulates | 16024783 | SIGNOR-138612 |
| IKBKB | YWHAB | Ser132 | GDYFRYLsEVASGDN | phosphorylation down-regulates | 16024783 | SIGNOR-138608 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | phosphorylation up-regulates → | YWHAB PSer186 | phosphorylation down-regulates ⊣ | YWHAB | 15696159 | SIGNOR-133875 |
| PRKCZ | phosphorylation up-regulates → | YWHAB PThr143 | phosphorylation down-regulates ⊣ | YWHAB | 10620507 | SIGNOR-249035 |
| PRKCD | phosphorylation up-regulates → | YWHAB PSer60 | phosphorylation down-regulates ⊣ | YWHAB | 16024783 | SIGNOR-138612 |
| IKBKB | phosphorylation up-regulates → | YWHAB PSer132 | phosphorylation down-regulates ⊣ | YWHAB | 16024783 | SIGNOR-138608 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK8 | phosphorylation down-regulates | YWHAB | SIGNOR-133875 |
| PRKCZ | phosphorylation → down-regulates activity | YWHAB | SIGNOR-249035 |
| PRKCD | phosphorylation down-regulates | YWHAB | SIGNOR-138612 |
| IKBKB | phosphorylation down-regulates | YWHAB | SIGNOR-138608 |
