| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | ARRB2 | Thr382 | EFDTNYAtDDDIVFE | phosphorylation unknown | 11877451 | SIGNOR-250829 |
| CSNK2A2 | ARRB2 | Thr382 | EFDTNYAtDDDIVFE | phosphorylation unknown | 11877451 | SIGNOR-250977 |
| ERK1/2 | ARRB2 | Thr276 | FCKVYTItPLLSDNR | phosphorylation up-regulates activity | 26324936 | SIGNOR-274019 |
| ERK1/2 | ARRB2 | Ser14 | TRVFKKSsPNCKLTV | phosphorylation up-regulates activity | 26324936 | SIGNOR-274018 |
| MAP2K1 | ARRB2 | Thr382 | EFDTNYAtDDDIVFE | phosphorylation up-regulates activity | 28169830 | SIGNOR-252027 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | phosphorylation up-regulates → | ARRB2 PThr382 | phosphorylation down-regulates ⊣ | ARRB2 | 11877451 | SIGNOR-250829 |
| CSNK2A2 | phosphorylation up-regulates → | ARRB2 PThr382 | phosphorylation down-regulates ⊣ | ARRB2 | 11877451 | SIGNOR-250977 |
| ERK1/2 | phosphorylation up-regulates → | ARRB2 PThr276 | phosphorylation up-regulates → | ARRB2 | 26324936 | SIGNOR-274019 |
| ERK1/2 | phosphorylation up-regulates → | ARRB2 PSer14 | phosphorylation up-regulates → | ARRB2 | 26324936 | SIGNOR-274018 |
| MAP2K1 | phosphorylation up-regulates → | ARRB2 PThr382 | phosphorylation up-regulates → | ARRB2 | 28169830 | SIGNOR-252027 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK2A1 | phosphorylation → unknown | ARRB2 | SIGNOR-250829 |
| CSNK2A2 | phosphorylation → unknown | ARRB2 | SIGNOR-250977 |
| ERK1/2 | phosphorylation → up-regulates activity | ARRB2 | SIGNOR-274019 |
| ERK1/2 | phosphorylation → up-regulates activity | ARRB2 | SIGNOR-274018 |
| MAP2K1 | phosphorylation → up-regulates activity | ARRB2 | SIGNOR-252027 |
