Entity Details

Name GRK4
ID P32298
Role kinase
Enzymatic Domains
RGS 52-172
PROSITE-ProRule
Protein kinase 187-449
PROSITE-ProRule
AGC-kinase C-terminal 450-515
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
GRK4BDKRB2Ser366EPIQMENsMGTLRTSphosphorylation
down-regulates activity		11517230SIGNOR-247902
GRK4BDKRB2Ser373SMGTLRTsISVERQIphosphorylation
down-regulates activity		11517230SIGNOR-251193
GRK4BDKRB2Ser375GTLRTSIsVERQIHKphosphorylation
down-regulates activity		11517230SIGNOR-249674
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
GRK4phosphorylation
up-regulates
→
BDKRB2
PSer366		phosphorylation
down-regulates
⊣		BDKRB211517230SIGNOR-247902
GRK4phosphorylation
up-regulates
→
BDKRB2
PSer373		phosphorylation
down-regulates
⊣		BDKRB211517230SIGNOR-251193
GRK4phosphorylation
up-regulates
→
BDKRB2
PSer375		phosphorylation
down-regulates
⊣		BDKRB211517230SIGNOR-249674
Regulator Mechanism/Effect Target SIGNOR-ID
GRK4phosphorylation
→
down-regulates activity 		BDKRB2SIGNOR-247902
GRK4phosphorylation
→
down-regulates activity 		BDKRB2SIGNOR-251193
GRK4phosphorylation
→
down-regulates activity 		BDKRB2SIGNOR-249674