| Name | CDH5 |
| ID | P33151 |
| Role | substrate |
| Enzymatic Domains |
Cadherin 1 48-151 PROSITE-ProRule
Cadherin 2 152-258 PROSITE-ProRule
Cadherin 3 259-372 PROSITE-ProRule
Cadherin 4 373-477 PROSITE-ProRule
Cadherin 5 478-593 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRB | CDH5 | – | dephosphorylation up-regulates activity | 19015309 | SIGNOR-277131 | |
| SRC | CDH5 | Tyr731 | PYDTLHIyGYEGSES | phosphorylation down-regulates activity | 16027153 | SIGNOR-246466 |
| SRC | CDH5 | Tyr658 | GEMDTTSyDVSVLNS | phosphorylation down-regulates activity | 16027153 | SIGNOR-246462 |
| SRC | CDH5 | Tyr685 | LDARPSLyAQVQKPP | phosphorylation up-regulates | 16909109 | SIGNOR-148818 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | phosphorylation up-regulates → | CDH5 PTyr731 | phosphorylation down-regulates ⊣ | CDH5 | 16027153 | SIGNOR-246466 |
| SRC | phosphorylation up-regulates → | CDH5 PTyr658 | phosphorylation down-regulates ⊣ | CDH5 | 16027153 | SIGNOR-246462 |
| SRC | phosphorylation up-regulates → | CDH5 PTyr685 | phosphorylation up-regulates → | CDH5 | 16909109 | SIGNOR-148818 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRB | dephosphorylation → up-regulates activity | CDH5 | SIGNOR-277131 |
| SRC | phosphorylation → down-regulates activity | CDH5 | SIGNOR-246466 |
| SRC | phosphorylation → down-regulates activity | CDH5 | SIGNOR-246462 |
| SRC | phosphorylation → up-regulates | CDH5 | SIGNOR-148818 |