| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | CTNNB1 | Ser29 | VSHWQQQsYLDSGIH | phosphorylation up-regulates quantity by stabilization | 12432063 | SIGNOR-275998 |
| PTK6 | CTNNB1 | Tyr331 | LVNIMRTyTYEKLLW | phosphorylation down-regulates quantity | 20026641 | SIGNOR-278287 |
| GSK3B | CTNNB1 | Ser33 | QQQSYLDsGIHSGAT | phosphorylation down-regulates activity | 11955436 | SIGNOR-116520 |
| MAPK9 | CTNNB1 | Ser605 | LFVQLLYsPIENIQR | phosphorylation up-regulates | 18423204 | SIGNOR-178262 |
| PTK2 | CTNNB1 | Tyr142 | AVVNLINyQDDAELA | phosphorylation unknown | 22264731 | SIGNOR-261946 |
| CSNK2A1 | CTNNB1 | Ser29 | VSHWQQQsYLDSGIH | phosphorylation up-regulates activity | 12432063 | SIGNOR-250846 |
| GSK3B | CTNNB1 | Ser37 | YLDSGIHsGATTTAP | phosphorylation down-regulates activity | 19303846 | SIGNOR-184785 |
| BCR-ABL | CTNNB1 | Tyr86 | VADIDGQyAMTRAQR | phosphorylation down-regulates | 17318191 | SIGNOR-153435 |
| RPS6KA5 | CTNNB1 | Ser552 | QDTQRRTsMGGTQQQ | phosphorylation up-regulates activity | 27196759 | SIGNOR-278247 |
| PRKCA | CTNNB1 | Ser33 | QQQSYLDsGIHSGAT | phosphorylation down-regulates | 25058461 | SIGNOR-278492 |
| PRKCA | CTNNB1 | Ser37 | YLDSGIHsGATTTAP | phosphorylation down-regulates | 25058461 | SIGNOR-278493 |
| GSK3B | CTNNB1 | Thr41 | GIHSGATtTAPSLSG | phosphorylation down-regulates activity | 11955436 | SIGNOR-260016 |
| CSNK2A2 | CTNNB1 | Thr112 | EGMQIPStQFDAAHP | phosphorylation up-regulates quantity by stabilization | 12432063 | SIGNOR-275994 |
| JAK3 | CTNNB1 | Tyr86 | VADIDGQyAMTRAQR | phosphorylation up-regulates activity | 28821617 | SIGNOR-278180 |
| GSK3B | CTNNB1 | Thr41 | GIHSGATtTAPSLSG | phosphorylation down-regulates activity | 11955436 | SIGNOR-116528 |
| CyclinD1/CDK6 | CTNNB1 | Ser45 | GATTTAPsLSGKGNP | phosphorylation down-regulates activity | 17208333 | SIGNOR-250647 |
| CDK5 | CTNNB1 | Ser191 | SRHAIMRsPQMVSAI | phosphorylation up-regulates activity | 26509276 | SIGNOR-279515 |
| CAMK2B | CTNNB1 | Ser552 | QDTQRRTsMGGTQQQ | phosphorylation down-regulates | 24117889 | SIGNOR-202825 |
| PRKACA | CTNNB1 | – | phosphorylation up-regulates activity | 16199882 | SIGNOR-140902 | |
| CSNK1A1 | CTNNB1 | Ser45 | GATTTAPsLSGKGNP | phosphorylation down-regulates | 20419129 | SIGNOR-165022 |
| PRKD1 | CTNNB1 | Thr120 | QFDAAHPtNVQRLAE | phosphorylation up-regulates | 19141652 | SIGNOR-183388 |
| GSK3B | CTNNB1 | Ser37 | YLDSGIHsGATTTAP | phosphorylation down-regulates activity | 11955436 | SIGNOR-116524 |
| GSK3B | CTNNB1 | Ser37 | YLDSGIHsGATTTAP | phosphorylation down-regulates activity | 16293724 | SIGNOR-141803 |
| CSNK1D | CTNNB1 | Ser45 | GATTTAPsLSGKGNP | phosphorylation down-regulates | 12000790 | SIGNOR-87441 |
| JNK | CTNNB1 | Thr41 | GIHSGATtTAPSLSG | phosphorylation down-regulates | 19667122 | SIGNOR-187582 |
| PLK1 | CTNNB1 | Ser718 | QDDPSYRsFHSGGYG | phosphorylation unknown | 19001871 | SIGNOR-182150 |
| CAMK2B | CTNNB1 | Thr472 | ICALRHLtSRHQEAE | phosphorylation down-regulates | 24117889 | SIGNOR-202833 |
| GSK3B/Axin/APC | CTNNB1 | Thr41 | GIHSGATtTAPSLSG | phosphorylation down-regulates activity | 19303846 | SIGNOR-227878 |
| JNK | CTNNB1 | Ser37 | YLDSGIHsGATTTAP | phosphorylation down-regulates | 20419129 | SIGNOR-165026 |
| GSK3B/Axin/APC | CTNNB1 | Ser37 | YLDSGIHsGATTTAP | phosphorylation down-regulates activity | 19303846 | SIGNOR-227874 |
| GSK3B/Axin/APC | CTNNB1 | Ser33 | QQQSYLDsGIHSGAT | phosphorylation down-regulates activity | 16293724 | SIGNOR-227885 |
| SRC | CTNNB1 | Tyr86 | VADIDGQyAMTRAQR | phosphorylation down-regulates activity | 11279024 | SIGNOR-106458 |
| NEK2 | CTNNB1 | Ser37 | YLDSGIHsGATTTAP | phosphorylation down-regulates quantity | 30968157 | SIGNOR-278172 |
| GSK3B/Axin/APC | CTNNB1 | Ser33 | QQQSYLDsGIHSGAT | phosphorylation down-regulates activity | 19303846 | SIGNOR-227870 |
| GSK3B/Axin/APC | CTNNB1 | – | phosphorylation down-regulates activity | 16293724 | SIGNOR-227893 | |
| FER | CTNNB1 | Tyr142 | AVVNLINyQDDAELA | phosphorylation down-regulates activity | 12640114 | SIGNOR-251131 |
| GSK3B | CTNNB1 | Ser33 | QQQSYLDsGIHSGAT | phosphorylation down-regulates activity | 23151663 | SIGNOR-199504 |
| CSNK2A1 | CTNNB1 | Thr393 | RNLSDAAtKQEGMEG | phosphorylation up-regulates activity | 12700239 | SIGNOR-250849 |
| PTPN6 | CTNNB1 | Tyr86 | VADIDGQyAMTRAQR | dephosphorylation down-regulates quantity by destabilization | 20840866 | SIGNOR-277013 |
| GSK3B | CTNNB1 | Thr41 | GIHSGATtTAPSLSG | phosphorylation down-regulates activity | 23151663 | SIGNOR-199512 |
| PRKCZ | CTNNB1 | Ser675 | QDYKKRLsVELTSSL | phosphorylation down-regulates quantity by destabilization | 25660024 | SIGNOR-276880 |
| MST1R | CTNNB1 | – | phosphorylation up-regulates activity | 21423209 | SIGNOR-279376 | |
| ERBB2 | CTNNB1 | Tyr654 | RNEGVATyAAAVLFR | phosphorylation down-regulates activity | 23576562 | SIGNOR-279041 |
| AURKA | CTNNB1 | Ser675 | QDYKKRLsVELTSSL | phosphorylation up-regulates quantity | 25217103 | SIGNOR-278469 |
| GSK3B | CTNNB1 | Thr41 | GIHSGATtTAPSLSG | phosphorylation down-regulates activity | 19303846 | SIGNOR-184789 |
| PAK4 | CTNNB1 | Ser675 | QDYKKRLsVELTSSL | phosphorylation up-regulates | 22173096 | SIGNOR-191557 |
| CAMK2B | CTNNB1 | Thr332 | VNIMRTYtYEKLLWT | phosphorylation down-regulates | 24117889 | SIGNOR-202829 |
| PTK6 | CTNNB1 | Tyr64 | VDTSQVLyEWEQGFS | phosphorylation down-regulates quantity | 20026641 | SIGNOR-278288 |
| PTK6 | CTNNB1 | Tyr333 | NIMRTYTyEKLLWTT | phosphorylation down-regulates quantity | 20026641 | SIGNOR-278289 |
| AKT2 | CTNNB1 | Ser552 | QDTQRRTsMGGTQQQ | phosphorylation up-regulates | 17287208 | SIGNOR-152958 |
| KIT | CTNNB1 | – | phosphorylation up-regulates activity | 17949810 | SIGNOR-278361 | |
| PAK1 | CTNNB1 | Ser675 | QDYKKRLsVELTSSL | phosphorylation up-regulates | 21822311 | SIGNOR-175944 |
| PRKCZ | CTNNB1 | Ser45 | GATTTAPsLSGKGNP | phosphorylation down-regulates quantity by destabilization | 25660024 | SIGNOR-276878 |
| PTPRJ | CTNNB1 | – | dephosphorylation up-regulates activity | 25386896 | SIGNOR-276992 | |
| GSK3B/Axin/APC | CTNNB1 | Thr41 | GIHSGATtTAPSLSG | phosphorylation down-regulates activity | 11955436 | SIGNOR-227905 |
| BCR-ABL | CTNNB1 | Tyr654 | RNEGVATyAAAVLFR | phosphorylation up-regulates | 17318191 | SIGNOR-153431 |
| PRKCZ | CTNNB1 | Ser552 | QDTQRRTsMGGTQQQ | phosphorylation down-regulates quantity by destabilization | 25660024 | SIGNOR-276879 |
| PTPN6 | CTNNB1 | Tyr654 | RNEGVATyAAAVLFR | dephosphorylation down-regulates quantity by destabilization | 20840866 | SIGNOR-277014 |
| CSNK2A1 | CTNNB1 | Thr102 | RAAMFPEtLDEGMQI | phosphorylation up-regulates activity | 12432063 | SIGNOR-250847 |
| NTRK1 | CTNNB1 | Tyr142 | AVVNLINyQDDAELA | phosphorylation up-regulates activity | 22558232 | SIGNOR-279240 |
| PRKCA | CTNNB1 | Thr41 | GIHSGATtTAPSLSG | phosphorylation down-regulates | 25058461 | SIGNOR-278494 |
| GSK3B/Axin/APC | CTNNB1 | Thr41 | GIHSGATtTAPSLSG | phosphorylation down-regulates activity | 23151663 | SIGNOR-227866 |
| PRKCD | CTNNB1 | Ser715 | GYRQDDPsYRSFHSG | phosphorylation down-regulates activity | 25639486 | SIGNOR-260897 |
| JAK3 | CTNNB1 | Tyr30 | SHWQQQSyLDSGIHS | phosphorylation up-regulates activity | 28821617 | SIGNOR-278178 |
| CSNK2A2 | CTNNB1 | Ser29 | VSHWQQQsYLDSGIH | phosphorylation up-regulates quantity by stabilization | 12432063 | SIGNOR-275995 |
| PTPRU | CTNNB1 | – | dephosphorylation down-regulates activity | 25337216 | SIGNOR-277095 | |
| CSNK2B | CTNNB1 | Ser29 | VSHWQQQsYLDSGIH | phosphorylation up-regulates activity | 12432063 | SIGNOR-251065 |
| CSNK2A1 | CTNNB1 | Thr112 | EGMQIPStQFDAAHP | phosphorylation up-regulates activity | 12432063 | SIGNOR-250848 |
| GSK3B/Axin/APC | CTNNB1 | Ser37 | YLDSGIHsGATTTAP | phosphorylation down-regulates activity | 16293724 | SIGNOR-227889 |
| GSK3B | CTNNB1 | Ser33 | QQQSYLDsGIHSGAT | phosphorylation down-regulates activity | 16293724 | SIGNOR-141799 |
| PRKD1 | CTNNB1 | Thr112 | EGMQIPStQFDAAHP | phosphorylation up-regulates | 19141652 | SIGNOR-183384 |
| GSK3B/Axin/APC | CTNNB1 | Ser37 | YLDSGIHsGATTTAP | phosphorylation down-regulates activity | 11955436 | SIGNOR-227901 |
| JAK3 | CTNNB1 | Tyr64 | VDTSQVLyEWEQGFS | phosphorylation up-regulates activity | 28821617 | SIGNOR-278179 |
| CSNK2A2 | CTNNB1 | Thr102 | RAAMFPEtLDEGMQI | phosphorylation up-regulates quantity by stabilization | 12432063 | SIGNOR-275993 |
| PRKACA | CTNNB1 | Ser552 | QDTQRRTsMGGTQQQ | phosphorylation up-regulates activity | 16476742 | SIGNOR-144478 |
| AKT1 | CTNNB1 | Ser552 | QDTQRRTsMGGTQQQ | phosphorylation up-regulates | 17287208 | SIGNOR-252499 |
| CSNK1A1L | CTNNB1 | Ser45 | GATTTAPsLSGKGNP | phosphorylation down-regulates | 12000790 | SIGNOR-87430 |
| STK26 | CTNNB1 | Thr40 | SGIHSGAtTTAPSLS | phosphorylation up-regulates quantity by stabilization | 34240584 | SIGNOR-280141 |
| GSK3B | CTNNB1 | Thr41 | GIHSGATtTAPSLSG | phosphorylation down-regulates activity | 16293724 | SIGNOR-141807 |
| PPP2CA | CTNNB1 | – | dephosphorylation up-regulates | 19061640 | SIGNOR-182637 | |
| GSK3B | CTNNB1 | Ser33 | QQQSYLDsGIHSGAT | phosphorylation down-regulates activity | 19303846 | SIGNOR-184781 |
| NEK2 | CTNNB1 | Ser33 | QQQSYLDsGIHSGAT | phosphorylation down-regulates quantity | 30968157 | SIGNOR-278173 |
| FYN | CTNNB1 | Tyr142 | AVVNLINyQDDAELA | phosphorylation down-regulates activity | 12640114 | SIGNOR-251162 |
| EGFR | CTNNB1 | Tyr142 | AVVNLINyQDDAELA | phosphorylation up-regulates activity | 22558232 | SIGNOR-278309 |
| CDK5 | CTNNB1 | Ser246 | ALVKMLGsPVDSVLF | phosphorylation up-regulates activity | 26509276 | SIGNOR-279516 |
| PAK6 | CTNNB1 | – | phosphorylation down-regulates quantity | 24352566 | SIGNOR-279546 | |
| SRC | CTNNB1 | Tyr333 | NIMRTYTyEKLLWTT | phosphorylation up-regulates | 22056988 | SIGNOR-177086 |
| CSNK2A1 | CTNNB1 | Thr112 | EGMQIPStQFDAAHP | phosphorylation up-regulates quantity by stabilization | 12432063 | SIGNOR-275997 |
| CHKA | CTNNB1 | – | phosphorylation down-regulates activity | 11818547 | SIGNOR-279161 | |
| PTK6 | CTNNB1 | Tyr142 | AVVNLINyQDDAELA | phosphorylation down-regulates quantity | 20026641 | SIGNOR-278286 |
| CHUK | CTNNB1 | – | phosphorylation up-regulates quantity | 22435559 | SIGNOR-280230 | |
| CSNK1E | CTNNB1 | Ser45 | GATTTAPsLSGKGNP | phosphorylation down-regulates activity | 12176352 | SIGNOR-244102 |
| GSK3B/Axin/APC | CTNNB1 | Ser33 | QQQSYLDsGIHSGAT | phosphorylation down-regulates activity | 11955436 | SIGNOR-227897 |
| PTPN1 | CTNNB1 | – | dephosphorylation up-regulates activity | 12377785 | SIGNOR-277121 | |
| AKT | CTNNB1 | Ser552 | QDTQRRTsMGGTQQQ | phosphorylation up-regulates | 17287208 | SIGNOR-244222 |
| SRC | CTNNB1 | Tyr654 | RNEGVATyAAAVLFR | phosphorylation up-regulates activity | 11279024 | SIGNOR-106454 |
| GSK3B/Axin/APC | CTNNB1 | Thr41 | GIHSGATtTAPSLSG | phosphorylation down-regulates activity | 11955436 | SIGNOR-260015 |
| FLT3 | CTNNB1 | – | phosphorylation up-regulates activity | 17851558 | SIGNOR-260124 | |
| CSNK2B | CTNNB1 | Thr112 | EGMQIPStQFDAAHP | phosphorylation up-regulates activity | 12432063 | SIGNOR-251067 |
| AURKA | CTNNB1 | Ser552 | QDTQRRTsMGGTQQQ | phosphorylation up-regulates quantity | 25217103 | SIGNOR-278468 |
| CSNK2A1 | CTNNB1 | Thr102 | RAAMFPEtLDEGMQI | phosphorylation up-regulates quantity by stabilization | 12432063 | SIGNOR-275996 |
| CSNK1E | CTNNB1 | Ser45 | GATTTAPsLSGKGNP | phosphorylation down-regulates | 12000790 | SIGNOR-87448 |
| MAPK9 | CTNNB1 | Ser191 | SRHAIMRsPQMVSAI | phosphorylation up-regulates | 18423204 | SIGNOR-178258 |
| CSNK2B | CTNNB1 | Thr102 | RAAMFPEtLDEGMQI | phosphorylation up-regulates activity | 12432063 | SIGNOR-251066 |
| PTPRZ1 | CTNNB1 | – | dephosphorylation up-regulates activity | 23100427 | SIGNOR-277044 | |
| EGFR | CTNNB1 | Tyr654 | RNEGVATyAAAVLFR | phosphorylation up-regulates activity | 25164010 | SIGNOR-278308 |
| JNK | CTNNB1 | Ser37 | YLDSGIHsGATTTAP | phosphorylation down-regulates | 19667122 | SIGNOR-187578 |
| PRKACA | CTNNB1 | Ser675 | QDYKKRLsVELTSSL | phosphorylation up-regulates activity | 16476742 | SIGNOR-144482 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | phosphorylation up-regulates → | CTNNB1 PSer29 | phosphorylation up-regulates → | CTNNB1 | 12432063 | SIGNOR-275998 |
| PTK6 | phosphorylation up-regulates → | CTNNB1 PTyr331 | phosphorylation down-regulates ⊣ | CTNNB1 | 20026641 | SIGNOR-278287 |
| GSK3B | phosphorylation up-regulates → | CTNNB1 PSer33 | phosphorylation down-regulates ⊣ | CTNNB1 | 11955436 | SIGNOR-116520 |
| MAPK9 | phosphorylation up-regulates → | CTNNB1 PSer605 | phosphorylation up-regulates → | CTNNB1 | 18423204 | SIGNOR-178262 |
| PTK2 | phosphorylation up-regulates → | CTNNB1 PTyr142 | phosphorylation down-regulates ⊣ | CTNNB1 | 22264731 | SIGNOR-261946 |
| CSNK2A1 | phosphorylation up-regulates → | CTNNB1 PSer29 | phosphorylation up-regulates → | CTNNB1 | 12432063 | SIGNOR-250846 |
| GSK3B | phosphorylation up-regulates → | CTNNB1 PSer37 | phosphorylation down-regulates ⊣ | CTNNB1 | 19303846 | SIGNOR-184785 |
| BCR-ABL | phosphorylation up-regulates → | CTNNB1 PTyr86 | phosphorylation down-regulates ⊣ | CTNNB1 | 17318191 | SIGNOR-153435 |
| RPS6KA5 | phosphorylation up-regulates → | CTNNB1 PSer552 | phosphorylation up-regulates → | CTNNB1 | 27196759 | SIGNOR-278247 |
| PRKCA | phosphorylation up-regulates → | CTNNB1 PSer33 | phosphorylation down-regulates ⊣ | CTNNB1 | 25058461 | SIGNOR-278492 |
| PRKCA | phosphorylation up-regulates → | CTNNB1 PSer37 | phosphorylation down-regulates ⊣ | CTNNB1 | 25058461 | SIGNOR-278493 |
| GSK3B | phosphorylation up-regulates → | CTNNB1 PThr41 | phosphorylation down-regulates ⊣ | CTNNB1 | 11955436 | SIGNOR-260016 |
| CSNK2A2 | phosphorylation up-regulates → | CTNNB1 PThr112 | phosphorylation up-regulates → | CTNNB1 | 12432063 | SIGNOR-275994 |
| JAK3 | phosphorylation up-regulates → | CTNNB1 PTyr86 | phosphorylation up-regulates → | CTNNB1 | 28821617 | SIGNOR-278180 |
| GSK3B | phosphorylation up-regulates → | CTNNB1 PThr41 | phosphorylation down-regulates ⊣ | CTNNB1 | 11955436 | SIGNOR-116528 |
| CyclinD1/CDK6 | phosphorylation up-regulates → | CTNNB1 PSer45 | phosphorylation down-regulates ⊣ | CTNNB1 | 17208333 | SIGNOR-250647 |
| CDK5 | phosphorylation up-regulates → | CTNNB1 PSer191 | phosphorylation up-regulates → | CTNNB1 | 26509276 | SIGNOR-279515 |
| CAMK2B | phosphorylation up-regulates → | CTNNB1 PSer552 | phosphorylation down-regulates ⊣ | CTNNB1 | 24117889 | SIGNOR-202825 |
| CSNK1A1 | phosphorylation up-regulates → | CTNNB1 PSer45 | phosphorylation down-regulates ⊣ | CTNNB1 | 20419129 | SIGNOR-165022 |
| PRKD1 | phosphorylation up-regulates → | CTNNB1 PThr120 | phosphorylation up-regulates → | CTNNB1 | 19141652 | SIGNOR-183388 |
| GSK3B | phosphorylation up-regulates → | CTNNB1 PSer37 | phosphorylation down-regulates ⊣ | CTNNB1 | 11955436 | SIGNOR-116524 |
| GSK3B | phosphorylation up-regulates → | CTNNB1 PSer37 | phosphorylation down-regulates ⊣ | CTNNB1 | 16293724 | SIGNOR-141803 |
| CSNK1D | phosphorylation up-regulates → | CTNNB1 PSer45 | phosphorylation down-regulates ⊣ | CTNNB1 | 12000790 | SIGNOR-87441 |
| JNK | phosphorylation up-regulates → | CTNNB1 PThr41 | phosphorylation down-regulates ⊣ | CTNNB1 | 19667122 | SIGNOR-187582 |
| PLK1 | phosphorylation up-regulates → | CTNNB1 PSer718 | phosphorylation down-regulates ⊣ | CTNNB1 | 19001871 | SIGNOR-182150 |
| CAMK2B | phosphorylation up-regulates → | CTNNB1 PThr472 | phosphorylation down-regulates ⊣ | CTNNB1 | 24117889 | SIGNOR-202833 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | CTNNB1 PThr41 | phosphorylation down-regulates ⊣ | CTNNB1 | 19303846 | SIGNOR-227878 |
| JNK | phosphorylation up-regulates → | CTNNB1 PSer37 | phosphorylation down-regulates ⊣ | CTNNB1 | 20419129 | SIGNOR-165026 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | CTNNB1 PSer37 | phosphorylation down-regulates ⊣ | CTNNB1 | 19303846 | SIGNOR-227874 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | CTNNB1 PSer33 | phosphorylation down-regulates ⊣ | CTNNB1 | 16293724 | SIGNOR-227885 |
| SRC | phosphorylation up-regulates → | CTNNB1 PTyr86 | phosphorylation down-regulates ⊣ | CTNNB1 | 11279024 | SIGNOR-106458 |
| NEK2 | phosphorylation up-regulates → | CTNNB1 PSer37 | phosphorylation down-regulates ⊣ | CTNNB1 | 30968157 | SIGNOR-278172 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | CTNNB1 PSer33 | phosphorylation down-regulates ⊣ | CTNNB1 | 19303846 | SIGNOR-227870 |
| FER | phosphorylation up-regulates → | CTNNB1 PTyr142 | phosphorylation down-regulates ⊣ | CTNNB1 | 12640114 | SIGNOR-251131 |
| GSK3B | phosphorylation up-regulates → | CTNNB1 PSer33 | phosphorylation down-regulates ⊣ | CTNNB1 | 23151663 | SIGNOR-199504 |
| CSNK2A1 | phosphorylation up-regulates → | CTNNB1 PThr393 | phosphorylation up-regulates → | CTNNB1 | 12700239 | SIGNOR-250849 |
| PTPN6 | dephosphorylation down-regulates ⊣ | CTNNB1 PTyr86 | dephosphorylation up-regulates → | CTNNB1 | 20840866 | SIGNOR-277013 |
| GSK3B | phosphorylation up-regulates → | CTNNB1 PThr41 | phosphorylation down-regulates ⊣ | CTNNB1 | 23151663 | SIGNOR-199512 |
| PRKCZ | phosphorylation up-regulates → | CTNNB1 PSer675 | phosphorylation down-regulates ⊣ | CTNNB1 | 25660024 | SIGNOR-276880 |
| ERBB2 | phosphorylation up-regulates → | CTNNB1 PTyr654 | phosphorylation down-regulates ⊣ | CTNNB1 | 23576562 | SIGNOR-279041 |
| AURKA | phosphorylation up-regulates → | CTNNB1 PSer675 | phosphorylation up-regulates → | CTNNB1 | 25217103 | SIGNOR-278469 |
| GSK3B | phosphorylation up-regulates → | CTNNB1 PThr41 | phosphorylation down-regulates ⊣ | CTNNB1 | 19303846 | SIGNOR-184789 |
| PAK4 | phosphorylation up-regulates → | CTNNB1 PSer675 | phosphorylation up-regulates → | CTNNB1 | 22173096 | SIGNOR-191557 |
| CAMK2B | phosphorylation up-regulates → | CTNNB1 PThr332 | phosphorylation down-regulates ⊣ | CTNNB1 | 24117889 | SIGNOR-202829 |
| PTK6 | phosphorylation up-regulates → | CTNNB1 PTyr64 | phosphorylation down-regulates ⊣ | CTNNB1 | 20026641 | SIGNOR-278288 |
| PTK6 | phosphorylation up-regulates → | CTNNB1 PTyr333 | phosphorylation down-regulates ⊣ | CTNNB1 | 20026641 | SIGNOR-278289 |
| AKT2 | phosphorylation up-regulates → | CTNNB1 PSer552 | phosphorylation up-regulates → | CTNNB1 | 17287208 | SIGNOR-152958 |
| PAK1 | phosphorylation up-regulates → | CTNNB1 PSer675 | phosphorylation up-regulates → | CTNNB1 | 21822311 | SIGNOR-175944 |
| PRKCZ | phosphorylation up-regulates → | CTNNB1 PSer45 | phosphorylation down-regulates ⊣ | CTNNB1 | 25660024 | SIGNOR-276878 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | CTNNB1 PThr41 | phosphorylation down-regulates ⊣ | CTNNB1 | 11955436 | SIGNOR-227905 |
| BCR-ABL | phosphorylation up-regulates → | CTNNB1 PTyr654 | phosphorylation up-regulates → | CTNNB1 | 17318191 | SIGNOR-153431 |
| PRKCZ | phosphorylation up-regulates → | CTNNB1 PSer552 | phosphorylation down-regulates ⊣ | CTNNB1 | 25660024 | SIGNOR-276879 |
| PTPN6 | dephosphorylation down-regulates ⊣ | CTNNB1 PTyr654 | dephosphorylation up-regulates → | CTNNB1 | 20840866 | SIGNOR-277014 |
| CSNK2A1 | phosphorylation up-regulates → | CTNNB1 PThr102 | phosphorylation up-regulates → | CTNNB1 | 12432063 | SIGNOR-250847 |
| NTRK1 | phosphorylation up-regulates → | CTNNB1 PTyr142 | phosphorylation up-regulates → | CTNNB1 | 22558232 | SIGNOR-279240 |
| PRKCA | phosphorylation up-regulates → | CTNNB1 PThr41 | phosphorylation down-regulates ⊣ | CTNNB1 | 25058461 | SIGNOR-278494 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | CTNNB1 PThr41 | phosphorylation down-regulates ⊣ | CTNNB1 | 23151663 | SIGNOR-227866 |
| PRKCD | phosphorylation up-regulates → | CTNNB1 PSer715 | phosphorylation down-regulates ⊣ | CTNNB1 | 25639486 | SIGNOR-260897 |
| JAK3 | phosphorylation up-regulates → | CTNNB1 PTyr30 | phosphorylation up-regulates → | CTNNB1 | 28821617 | SIGNOR-278178 |
| CSNK2A2 | phosphorylation up-regulates → | CTNNB1 PSer29 | phosphorylation up-regulates → | CTNNB1 | 12432063 | SIGNOR-275995 |
| CSNK2B | phosphorylation up-regulates → | CTNNB1 PSer29 | phosphorylation up-regulates → | CTNNB1 | 12432063 | SIGNOR-251065 |
| CSNK2A1 | phosphorylation up-regulates → | CTNNB1 PThr112 | phosphorylation up-regulates → | CTNNB1 | 12432063 | SIGNOR-250848 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | CTNNB1 PSer37 | phosphorylation down-regulates ⊣ | CTNNB1 | 16293724 | SIGNOR-227889 |
| GSK3B | phosphorylation up-regulates → | CTNNB1 PSer33 | phosphorylation down-regulates ⊣ | CTNNB1 | 16293724 | SIGNOR-141799 |
| PRKD1 | phosphorylation up-regulates → | CTNNB1 PThr112 | phosphorylation up-regulates → | CTNNB1 | 19141652 | SIGNOR-183384 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | CTNNB1 PSer37 | phosphorylation down-regulates ⊣ | CTNNB1 | 11955436 | SIGNOR-227901 |
| JAK3 | phosphorylation up-regulates → | CTNNB1 PTyr64 | phosphorylation up-regulates → | CTNNB1 | 28821617 | SIGNOR-278179 |
| CSNK2A2 | phosphorylation up-regulates → | CTNNB1 PThr102 | phosphorylation up-regulates → | CTNNB1 | 12432063 | SIGNOR-275993 |
| PRKACA | phosphorylation up-regulates → | CTNNB1 PSer552 | phosphorylation up-regulates → | CTNNB1 | 16476742 | SIGNOR-144478 |
| AKT1 | phosphorylation up-regulates → | CTNNB1 PSer552 | phosphorylation up-regulates → | CTNNB1 | 17287208 | SIGNOR-252499 |
| CSNK1A1L | phosphorylation up-regulates → | CTNNB1 PSer45 | phosphorylation down-regulates ⊣ | CTNNB1 | 12000790 | SIGNOR-87430 |
| STK26 | phosphorylation up-regulates → | CTNNB1 PThr40 | phosphorylation up-regulates → | CTNNB1 | 34240584 | SIGNOR-280141 |
| GSK3B | phosphorylation up-regulates → | CTNNB1 PThr41 | phosphorylation down-regulates ⊣ | CTNNB1 | 16293724 | SIGNOR-141807 |
| GSK3B | phosphorylation up-regulates → | CTNNB1 PSer33 | phosphorylation down-regulates ⊣ | CTNNB1 | 19303846 | SIGNOR-184781 |
| NEK2 | phosphorylation up-regulates → | CTNNB1 PSer33 | phosphorylation down-regulates ⊣ | CTNNB1 | 30968157 | SIGNOR-278173 |
| FYN | phosphorylation up-regulates → | CTNNB1 PTyr142 | phosphorylation down-regulates ⊣ | CTNNB1 | 12640114 | SIGNOR-251162 |
| EGFR | phosphorylation up-regulates → | CTNNB1 PTyr142 | phosphorylation up-regulates → | CTNNB1 | 22558232 | SIGNOR-278309 |
| CDK5 | phosphorylation up-regulates → | CTNNB1 PSer246 | phosphorylation up-regulates → | CTNNB1 | 26509276 | SIGNOR-279516 |
| SRC | phosphorylation up-regulates → | CTNNB1 PTyr333 | phosphorylation up-regulates → | CTNNB1 | 22056988 | SIGNOR-177086 |
| CSNK2A1 | phosphorylation up-regulates → | CTNNB1 PThr112 | phosphorylation up-regulates → | CTNNB1 | 12432063 | SIGNOR-275997 |
| PTK6 | phosphorylation up-regulates → | CTNNB1 PTyr142 | phosphorylation down-regulates ⊣ | CTNNB1 | 20026641 | SIGNOR-278286 |
| CSNK1E | phosphorylation up-regulates → | CTNNB1 PSer45 | phosphorylation down-regulates ⊣ | CTNNB1 | 12176352 | SIGNOR-244102 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | CTNNB1 PSer33 | phosphorylation down-regulates ⊣ | CTNNB1 | 11955436 | SIGNOR-227897 |
| AKT | phosphorylation up-regulates → | CTNNB1 PSer552 | phosphorylation up-regulates → | CTNNB1 | 17287208 | SIGNOR-244222 |
| SRC | phosphorylation up-regulates → | CTNNB1 PTyr654 | phosphorylation up-regulates → | CTNNB1 | 11279024 | SIGNOR-106454 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | CTNNB1 PThr41 | phosphorylation down-regulates ⊣ | CTNNB1 | 11955436 | SIGNOR-260015 |
| CSNK2B | phosphorylation up-regulates → | CTNNB1 PThr112 | phosphorylation up-regulates → | CTNNB1 | 12432063 | SIGNOR-251067 |
| AURKA | phosphorylation up-regulates → | CTNNB1 PSer552 | phosphorylation up-regulates → | CTNNB1 | 25217103 | SIGNOR-278468 |
| CSNK2A1 | phosphorylation up-regulates → | CTNNB1 PThr102 | phosphorylation up-regulates → | CTNNB1 | 12432063 | SIGNOR-275996 |
| CSNK1E | phosphorylation up-regulates → | CTNNB1 PSer45 | phosphorylation down-regulates ⊣ | CTNNB1 | 12000790 | SIGNOR-87448 |
| MAPK9 | phosphorylation up-regulates → | CTNNB1 PSer191 | phosphorylation up-regulates → | CTNNB1 | 18423204 | SIGNOR-178258 |
| CSNK2B | phosphorylation up-regulates → | CTNNB1 PThr102 | phosphorylation up-regulates → | CTNNB1 | 12432063 | SIGNOR-251066 |
| EGFR | phosphorylation up-regulates → | CTNNB1 PTyr654 | phosphorylation up-regulates → | CTNNB1 | 25164010 | SIGNOR-278308 |
| JNK | phosphorylation up-regulates → | CTNNB1 PSer37 | phosphorylation down-regulates ⊣ | CTNNB1 | 19667122 | SIGNOR-187578 |
| PRKACA | phosphorylation up-regulates → | CTNNB1 PSer675 | phosphorylation up-regulates → | CTNNB1 | 16476742 | SIGNOR-144482 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK2A1 | phosphorylation → up-regulates quantity by stabilization | CTNNB1 | SIGNOR-275998 |
| PTK6 | phosphorylation → down-regulates quantity | CTNNB1 | SIGNOR-278287 |
| GSK3B | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-116520 |
| MAPK9 | phosphorylation → up-regulates | CTNNB1 | SIGNOR-178262 |
| PTK2 | phosphorylation → unknown | CTNNB1 | SIGNOR-261946 |
| CSNK2A1 | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-250846 |
| GSK3B | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-184785 |
| BCR-ABL | phosphorylation down-regulates | CTNNB1 | SIGNOR-153435 |
| RPS6KA5 | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-278247 |
| PRKCA | phosphorylation down-regulates | CTNNB1 | SIGNOR-278492 |
| PRKCA | phosphorylation down-regulates | CTNNB1 | SIGNOR-278493 |
| GSK3B | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-260016 |
| CSNK2A2 | phosphorylation → up-regulates quantity by stabilization | CTNNB1 | SIGNOR-275994 |
| JAK3 | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-278180 |
| GSK3B | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-116528 |
| CyclinD1/CDK6 | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-250647 |
| CDK5 | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-279515 |
| CAMK2B | phosphorylation down-regulates | CTNNB1 | SIGNOR-202825 |
| PRKACA | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-140902 |
| CSNK1A1 | phosphorylation down-regulates | CTNNB1 | SIGNOR-165022 |
| PRKD1 | phosphorylation → up-regulates | CTNNB1 | SIGNOR-183388 |
| GSK3B | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-116524 |
| GSK3B | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-141803 |
| CSNK1D | phosphorylation down-regulates | CTNNB1 | SIGNOR-87441 |
| JNK | phosphorylation down-regulates | CTNNB1 | SIGNOR-187582 |
| PLK1 | phosphorylation → unknown | CTNNB1 | SIGNOR-182150 |
| CAMK2B | phosphorylation down-regulates | CTNNB1 | SIGNOR-202833 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-227878 |
| JNK | phosphorylation down-regulates | CTNNB1 | SIGNOR-165026 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-227874 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-227885 |
| SRC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-106458 |
| NEK2 | phosphorylation → down-regulates quantity | CTNNB1 | SIGNOR-278172 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-227870 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-227893 |
| FER | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-251131 |
| GSK3B | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-199504 |
| CSNK2A1 | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-250849 |
| PTPN6 | dephosphorylation down-regulates quantity by destabilization | CTNNB1 | SIGNOR-277013 |
| GSK3B | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-199512 |
| PRKCZ | phosphorylation down-regulates quantity by destabilization | CTNNB1 | SIGNOR-276880 |
| MST1R | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-279376 |
| ERBB2 | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-279041 |
| AURKA | phosphorylation → up-regulates quantity | CTNNB1 | SIGNOR-278469 |
| GSK3B | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-184789 |
| PAK4 | phosphorylation → up-regulates | CTNNB1 | SIGNOR-191557 |
| CAMK2B | phosphorylation down-regulates | CTNNB1 | SIGNOR-202829 |
| PTK6 | phosphorylation → down-regulates quantity | CTNNB1 | SIGNOR-278288 |
| PTK6 | phosphorylation → down-regulates quantity | CTNNB1 | SIGNOR-278289 |
| AKT2 | phosphorylation → up-regulates | CTNNB1 | SIGNOR-152958 |
| KIT | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-278361 |
| PAK1 | phosphorylation → up-regulates | CTNNB1 | SIGNOR-175944 |
| PRKCZ | phosphorylation down-regulates quantity by destabilization | CTNNB1 | SIGNOR-276878 |
| PTPRJ | dephosphorylation → up-regulates activity | CTNNB1 | SIGNOR-276992 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-227905 |
| BCR-ABL | phosphorylation → up-regulates | CTNNB1 | SIGNOR-153431 |
| PRKCZ | phosphorylation down-regulates quantity by destabilization | CTNNB1 | SIGNOR-276879 |
| PTPN6 | dephosphorylation down-regulates quantity by destabilization | CTNNB1 | SIGNOR-277014 |
| CSNK2A1 | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-250847 |
| NTRK1 | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-279240 |
| PRKCA | phosphorylation down-regulates | CTNNB1 | SIGNOR-278494 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-227866 |
| PRKCD | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-260897 |
| JAK3 | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-278178 |
| CSNK2A2 | phosphorylation → up-regulates quantity by stabilization | CTNNB1 | SIGNOR-275995 |
| PTPRU | dephosphorylation → down-regulates activity | CTNNB1 | SIGNOR-277095 |
| CSNK2B | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-251065 |
| CSNK2A1 | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-250848 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-227889 |
| GSK3B | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-141799 |
| PRKD1 | phosphorylation → up-regulates | CTNNB1 | SIGNOR-183384 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-227901 |
| JAK3 | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-278179 |
| CSNK2A2 | phosphorylation → up-regulates quantity by stabilization | CTNNB1 | SIGNOR-275993 |
| PRKACA | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-144478 |
| AKT1 | phosphorylation → up-regulates | CTNNB1 | SIGNOR-252499 |
| CSNK1A1L | phosphorylation down-regulates | CTNNB1 | SIGNOR-87430 |
| STK26 | phosphorylation → up-regulates quantity by stabilization | CTNNB1 | SIGNOR-280141 |
| GSK3B | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-141807 |
| PPP2CA | dephosphorylation → up-regulates | CTNNB1 | SIGNOR-182637 |
| GSK3B | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-184781 |
| NEK2 | phosphorylation → down-regulates quantity | CTNNB1 | SIGNOR-278173 |
| FYN | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-251162 |
| EGFR | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-278309 |
| CDK5 | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-279516 |
| PAK6 | phosphorylation → down-regulates quantity | CTNNB1 | SIGNOR-279546 |
| SRC | phosphorylation → up-regulates | CTNNB1 | SIGNOR-177086 |
| CSNK2A1 | phosphorylation → up-regulates quantity by stabilization | CTNNB1 | SIGNOR-275997 |
| CHKA | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-279161 |
| PTK6 | phosphorylation → down-regulates quantity | CTNNB1 | SIGNOR-278286 |
| CHUK | phosphorylation → up-regulates quantity | CTNNB1 | SIGNOR-280230 |
| CSNK1E | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-244102 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-227897 |
| PTPN1 | dephosphorylation → up-regulates activity | CTNNB1 | SIGNOR-277121 |
| AKT | phosphorylation → up-regulates | CTNNB1 | SIGNOR-244222 |
| SRC | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-106454 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-260015 |
| FLT3 | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-260124 |
| CSNK2B | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-251067 |
| AURKA | phosphorylation → up-regulates quantity | CTNNB1 | SIGNOR-278468 |
| CSNK2A1 | phosphorylation → up-regulates quantity by stabilization | CTNNB1 | SIGNOR-275996 |
| CSNK1E | phosphorylation down-regulates | CTNNB1 | SIGNOR-87448 |
| MAPK9 | phosphorylation → up-regulates | CTNNB1 | SIGNOR-178258 |
| CSNK2B | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-251066 |
| PTPRZ1 | dephosphorylation → up-regulates activity | CTNNB1 | SIGNOR-277044 |
| EGFR | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-278308 |
| JNK | phosphorylation down-regulates | CTNNB1 | SIGNOR-187578 |
| PRKACA | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-144482 |
