| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERBB2 | CTNNB1 | Tyr654 | RNEGVATyAAAVLFR | phosphorylation down-regulates activity | 23576562 | SIGNOR-279041 |
| BCR-ABL | CTNNB1 | Tyr654 | RNEGVATyAAAVLFR | phosphorylation up-regulates | 17318191 | SIGNOR-153431 |
| PTPN6 | CTNNB1 | Tyr654 | RNEGVATyAAAVLFR | dephosphorylation down-regulates quantity by destabilization | 20840866 | SIGNOR-277014 |
| EGFR | CTNNB1 | Tyr654 | RNEGVATyAAAVLFR | phosphorylation up-regulates activity | 25164010 | SIGNOR-278308 |
| SRC | CTNNB1 | Tyr654 | RNEGVATyAAAVLFR | phosphorylation up-regulates activity | 11279024 | SIGNOR-106454 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERBB2 | phosphorylation up-regulates → | CTNNB1 PTyr654 | phosphorylation down-regulates ⊣ | CTNNB1 | 23576562 | SIGNOR-279041 |
| BCR-ABL | phosphorylation up-regulates → | CTNNB1 PTyr654 | phosphorylation up-regulates → | CTNNB1 | 17318191 | SIGNOR-153431 |
| PTPN6 | dephosphorylation down-regulates ⊣ | CTNNB1 PTyr654 | dephosphorylation up-regulates → | CTNNB1 | 20840866 | SIGNOR-277014 |
| EGFR | phosphorylation up-regulates → | CTNNB1 PTyr654 | phosphorylation up-regulates → | CTNNB1 | 25164010 | SIGNOR-278308 |
| SRC | phosphorylation up-regulates → | CTNNB1 PTyr654 | phosphorylation up-regulates → | CTNNB1 | 11279024 | SIGNOR-106454 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ERBB2 | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-279041 |
| BCR-ABL | phosphorylation → up-regulates | CTNNB1 | SIGNOR-153431 |
| PTPN6 | dephosphorylation down-regulates quantity by destabilization | CTNNB1 | SIGNOR-277014 |
| EGFR | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-278308 |
| SRC | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-106454 |
