| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BCR-ABL | CTNNB1 | Tyr86 | VADIDGQyAMTRAQR | phosphorylation down-regulates | 17318191 | SIGNOR-153435 |
| JAK3 | CTNNB1 | Tyr86 | VADIDGQyAMTRAQR | phosphorylation up-regulates activity | 28821617 | SIGNOR-278180 |
| SRC | CTNNB1 | Tyr86 | VADIDGQyAMTRAQR | phosphorylation down-regulates activity | 11279024 | SIGNOR-106458 |
| PTPN6 | CTNNB1 | Tyr86 | VADIDGQyAMTRAQR | dephosphorylation down-regulates quantity by destabilization | 20840866 | SIGNOR-277013 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BCR-ABL | phosphorylation up-regulates → | CTNNB1 PTyr86 | phosphorylation down-regulates ⊣ | CTNNB1 | 17318191 | SIGNOR-153435 |
| JAK3 | phosphorylation up-regulates → | CTNNB1 PTyr86 | phosphorylation up-regulates → | CTNNB1 | 28821617 | SIGNOR-278180 |
| SRC | phosphorylation up-regulates → | CTNNB1 PTyr86 | phosphorylation down-regulates ⊣ | CTNNB1 | 11279024 | SIGNOR-106458 |
| PTPN6 | dephosphorylation down-regulates ⊣ | CTNNB1 PTyr86 | dephosphorylation up-regulates → | CTNNB1 | 20840866 | SIGNOR-277013 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| BCR-ABL | phosphorylation down-regulates | CTNNB1 | SIGNOR-153435 |
| JAK3 | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-278180 |
| SRC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-106458 |
| PTPN6 | dephosphorylation down-regulates quantity by destabilization | CTNNB1 | SIGNOR-277013 |
