| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK1E | CTNNB1 | Ser45 | GATTTAPsLSGKGNP | phosphorylation down-regulates | 12000790 | SIGNOR-87448 |
| CSNK1A1 | CTNNB1 | Ser45 | GATTTAPsLSGKGNP | phosphorylation down-regulates | 20419129 | SIGNOR-165022 |
| CSNK1E | CTNNB1 | Ser45 | GATTTAPsLSGKGNP | phosphorylation down-regulates activity | 12176352 | SIGNOR-244102 |
| CSNK1D | CTNNB1 | Ser45 | GATTTAPsLSGKGNP | phosphorylation down-regulates | 12000790 | SIGNOR-87441 |
| CSNK1A1L | CTNNB1 | Ser45 | GATTTAPsLSGKGNP | phosphorylation down-regulates | 12000790 | SIGNOR-87430 |
| CyclinD1/CDK6 | CTNNB1 | Ser45 | GATTTAPsLSGKGNP | phosphorylation down-regulates activity | 17208333 | SIGNOR-250647 |
| PRKCZ | CTNNB1 | Ser45 | GATTTAPsLSGKGNP | phosphorylation down-regulates quantity by destabilization | 25660024 | SIGNOR-276878 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK1E | phosphorylation up-regulates → | CTNNB1 PSer45 | phosphorylation down-regulates ⊣ | CTNNB1 | 12000790 | SIGNOR-87448 |
| CSNK1A1 | phosphorylation up-regulates → | CTNNB1 PSer45 | phosphorylation down-regulates ⊣ | CTNNB1 | 20419129 | SIGNOR-165022 |
| CSNK1E | phosphorylation up-regulates → | CTNNB1 PSer45 | phosphorylation down-regulates ⊣ | CTNNB1 | 12176352 | SIGNOR-244102 |
| CSNK1D | phosphorylation up-regulates → | CTNNB1 PSer45 | phosphorylation down-regulates ⊣ | CTNNB1 | 12000790 | SIGNOR-87441 |
| CSNK1A1L | phosphorylation up-regulates → | CTNNB1 PSer45 | phosphorylation down-regulates ⊣ | CTNNB1 | 12000790 | SIGNOR-87430 |
| CyclinD1/CDK6 | phosphorylation up-regulates → | CTNNB1 PSer45 | phosphorylation down-regulates ⊣ | CTNNB1 | 17208333 | SIGNOR-250647 |
| PRKCZ | phosphorylation up-regulates → | CTNNB1 PSer45 | phosphorylation down-regulates ⊣ | CTNNB1 | 25660024 | SIGNOR-276878 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK1E | phosphorylation down-regulates | CTNNB1 | SIGNOR-87448 |
| CSNK1A1 | phosphorylation down-regulates | CTNNB1 | SIGNOR-165022 |
| CSNK1E | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-244102 |
| CSNK1D | phosphorylation down-regulates | CTNNB1 | SIGNOR-87441 |
| CSNK1A1L | phosphorylation down-regulates | CTNNB1 | SIGNOR-87430 |
| CyclinD1/CDK6 | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-250647 |
| PRKCZ | phosphorylation down-regulates quantity by destabilization | CTNNB1 | SIGNOR-276878 |
