| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | CTNNB1 | Thr41 | GIHSGATtTAPSLSG | phosphorylation down-regulates activity | 23151663 | SIGNOR-199512 |
| PRKCA | CTNNB1 | Thr41 | GIHSGATtTAPSLSG | phosphorylation down-regulates | 25058461 | SIGNOR-278494 |
| GSK3B/Axin/APC | CTNNB1 | Thr41 | GIHSGATtTAPSLSG | phosphorylation down-regulates activity | 23151663 | SIGNOR-227866 |
| GSK3B/Axin/APC | CTNNB1 | Thr41 | GIHSGATtTAPSLSG | phosphorylation down-regulates activity | 19303846 | SIGNOR-227878 |
| GSK3B | CTNNB1 | Thr41 | GIHSGATtTAPSLSG | phosphorylation down-regulates activity | 11955436 | SIGNOR-116528 |
| GSK3B | CTNNB1 | Thr41 | GIHSGATtTAPSLSG | phosphorylation down-regulates activity | 16293724 | SIGNOR-141807 |
| GSK3B | CTNNB1 | Thr41 | GIHSGATtTAPSLSG | phosphorylation down-regulates activity | 19303846 | SIGNOR-184789 |
| GSK3B | CTNNB1 | Thr41 | GIHSGATtTAPSLSG | phosphorylation down-regulates activity | 11955436 | SIGNOR-260016 |
| JNK | CTNNB1 | Thr41 | GIHSGATtTAPSLSG | phosphorylation down-regulates | 19667122 | SIGNOR-187582 |
| GSK3B/Axin/APC | CTNNB1 | Thr41 | GIHSGATtTAPSLSG | phosphorylation down-regulates activity | 11955436 | SIGNOR-227905 |
| GSK3B/Axin/APC | CTNNB1 | Thr41 | GIHSGATtTAPSLSG | phosphorylation down-regulates activity | 11955436 | SIGNOR-260015 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | CTNNB1 PThr41 | phosphorylation down-regulates ⊣ | CTNNB1 | 23151663 | SIGNOR-199512 |
| PRKCA | phosphorylation up-regulates → | CTNNB1 PThr41 | phosphorylation down-regulates ⊣ | CTNNB1 | 25058461 | SIGNOR-278494 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | CTNNB1 PThr41 | phosphorylation down-regulates ⊣ | CTNNB1 | 23151663 | SIGNOR-227866 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | CTNNB1 PThr41 | phosphorylation down-regulates ⊣ | CTNNB1 | 19303846 | SIGNOR-227878 |
| GSK3B | phosphorylation up-regulates → | CTNNB1 PThr41 | phosphorylation down-regulates ⊣ | CTNNB1 | 11955436 | SIGNOR-116528 |
| GSK3B | phosphorylation up-regulates → | CTNNB1 PThr41 | phosphorylation down-regulates ⊣ | CTNNB1 | 16293724 | SIGNOR-141807 |
| GSK3B | phosphorylation up-regulates → | CTNNB1 PThr41 | phosphorylation down-regulates ⊣ | CTNNB1 | 19303846 | SIGNOR-184789 |
| GSK3B | phosphorylation up-regulates → | CTNNB1 PThr41 | phosphorylation down-regulates ⊣ | CTNNB1 | 11955436 | SIGNOR-260016 |
| JNK | phosphorylation up-regulates → | CTNNB1 PThr41 | phosphorylation down-regulates ⊣ | CTNNB1 | 19667122 | SIGNOR-187582 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | CTNNB1 PThr41 | phosphorylation down-regulates ⊣ | CTNNB1 | 11955436 | SIGNOR-227905 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | CTNNB1 PThr41 | phosphorylation down-regulates ⊣ | CTNNB1 | 11955436 | SIGNOR-260015 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-199512 |
| PRKCA | phosphorylation down-regulates | CTNNB1 | SIGNOR-278494 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-227866 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-227878 |
| GSK3B | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-116528 |
| GSK3B | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-141807 |
| GSK3B | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-184789 |
| GSK3B | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-260016 |
| JNK | phosphorylation down-regulates | CTNNB1 | SIGNOR-187582 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-227905 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-260015 |
