| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B/Axin/APC | CTNNB1 | Ser33 | QQQSYLDsGIHSGAT | phosphorylation down-regulates activity | 16293724 | SIGNOR-227885 |
| GSK3B/Axin/APC | CTNNB1 | Ser33 | QQQSYLDsGIHSGAT | phosphorylation down-regulates activity | 19303846 | SIGNOR-227870 |
| GSK3B | CTNNB1 | Ser33 | QQQSYLDsGIHSGAT | phosphorylation down-regulates activity | 19303846 | SIGNOR-184781 |
| GSK3B | CTNNB1 | Ser33 | QQQSYLDsGIHSGAT | phosphorylation down-regulates activity | 23151663 | SIGNOR-199504 |
| NEK2 | CTNNB1 | Ser33 | QQQSYLDsGIHSGAT | phosphorylation down-regulates quantity | 30968157 | SIGNOR-278173 |
| GSK3B/Axin/APC | CTNNB1 | Ser33 | QQQSYLDsGIHSGAT | phosphorylation down-regulates activity | 11955436 | SIGNOR-227897 |
| GSK3B | CTNNB1 | Ser33 | QQQSYLDsGIHSGAT | phosphorylation down-regulates activity | 16293724 | SIGNOR-141799 |
| GSK3B | CTNNB1 | Ser33 | QQQSYLDsGIHSGAT | phosphorylation down-regulates activity | 11955436 | SIGNOR-116520 |
| PRKCA | CTNNB1 | Ser33 | QQQSYLDsGIHSGAT | phosphorylation down-regulates | 25058461 | SIGNOR-278492 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B/Axin/APC | phosphorylation up-regulates → | CTNNB1 PSer33 | phosphorylation down-regulates ⊣ | CTNNB1 | 16293724 | SIGNOR-227885 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | CTNNB1 PSer33 | phosphorylation down-regulates ⊣ | CTNNB1 | 19303846 | SIGNOR-227870 |
| GSK3B | phosphorylation up-regulates → | CTNNB1 PSer33 | phosphorylation down-regulates ⊣ | CTNNB1 | 19303846 | SIGNOR-184781 |
| GSK3B | phosphorylation up-regulates → | CTNNB1 PSer33 | phosphorylation down-regulates ⊣ | CTNNB1 | 23151663 | SIGNOR-199504 |
| NEK2 | phosphorylation up-regulates → | CTNNB1 PSer33 | phosphorylation down-regulates ⊣ | CTNNB1 | 30968157 | SIGNOR-278173 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | CTNNB1 PSer33 | phosphorylation down-regulates ⊣ | CTNNB1 | 11955436 | SIGNOR-227897 |
| GSK3B | phosphorylation up-regulates → | CTNNB1 PSer33 | phosphorylation down-regulates ⊣ | CTNNB1 | 16293724 | SIGNOR-141799 |
| GSK3B | phosphorylation up-regulates → | CTNNB1 PSer33 | phosphorylation down-regulates ⊣ | CTNNB1 | 11955436 | SIGNOR-116520 |
| PRKCA | phosphorylation up-regulates → | CTNNB1 PSer33 | phosphorylation down-regulates ⊣ | CTNNB1 | 25058461 | SIGNOR-278492 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-227885 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-227870 |
| GSK3B | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-184781 |
| GSK3B | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-199504 |
| NEK2 | phosphorylation → down-regulates quantity | CTNNB1 | SIGNOR-278173 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-227897 |
| GSK3B | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-141799 |
| GSK3B | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-116520 |
| PRKCA | phosphorylation down-regulates | CTNNB1 | SIGNOR-278492 |
