| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B/Axin/APC | CTNNB1 | Ser37 | YLDSGIHsGATTTAP | phosphorylation down-regulates activity | 11955436 | SIGNOR-227901 |
| JNK | CTNNB1 | Ser37 | YLDSGIHsGATTTAP | phosphorylation down-regulates | 19667122 | SIGNOR-187578 |
| GSK3B/Axin/APC | CTNNB1 | Ser37 | YLDSGIHsGATTTAP | phosphorylation down-regulates activity | 16293724 | SIGNOR-227889 |
| GSK3B | CTNNB1 | Ser37 | YLDSGIHsGATTTAP | phosphorylation down-regulates activity | 19303846 | SIGNOR-184785 |
| PRKCA | CTNNB1 | Ser37 | YLDSGIHsGATTTAP | phosphorylation down-regulates | 25058461 | SIGNOR-278493 |
| GSK3B | CTNNB1 | Ser37 | YLDSGIHsGATTTAP | phosphorylation down-regulates activity | 11955436 | SIGNOR-116524 |
| GSK3B | CTNNB1 | Ser37 | YLDSGIHsGATTTAP | phosphorylation down-regulates activity | 16293724 | SIGNOR-141803 |
| JNK | CTNNB1 | Ser37 | YLDSGIHsGATTTAP | phosphorylation down-regulates | 20419129 | SIGNOR-165026 |
| GSK3B/Axin/APC | CTNNB1 | Ser37 | YLDSGIHsGATTTAP | phosphorylation down-regulates activity | 19303846 | SIGNOR-227874 |
| NEK2 | CTNNB1 | Ser37 | YLDSGIHsGATTTAP | phosphorylation down-regulates quantity | 30968157 | SIGNOR-278172 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B/Axin/APC | phosphorylation up-regulates → | CTNNB1 PSer37 | phosphorylation down-regulates ⊣ | CTNNB1 | 11955436 | SIGNOR-227901 |
| JNK | phosphorylation up-regulates → | CTNNB1 PSer37 | phosphorylation down-regulates ⊣ | CTNNB1 | 19667122 | SIGNOR-187578 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | CTNNB1 PSer37 | phosphorylation down-regulates ⊣ | CTNNB1 | 16293724 | SIGNOR-227889 |
| GSK3B | phosphorylation up-regulates → | CTNNB1 PSer37 | phosphorylation down-regulates ⊣ | CTNNB1 | 19303846 | SIGNOR-184785 |
| PRKCA | phosphorylation up-regulates → | CTNNB1 PSer37 | phosphorylation down-regulates ⊣ | CTNNB1 | 25058461 | SIGNOR-278493 |
| GSK3B | phosphorylation up-regulates → | CTNNB1 PSer37 | phosphorylation down-regulates ⊣ | CTNNB1 | 11955436 | SIGNOR-116524 |
| GSK3B | phosphorylation up-regulates → | CTNNB1 PSer37 | phosphorylation down-regulates ⊣ | CTNNB1 | 16293724 | SIGNOR-141803 |
| JNK | phosphorylation up-regulates → | CTNNB1 PSer37 | phosphorylation down-regulates ⊣ | CTNNB1 | 20419129 | SIGNOR-165026 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | CTNNB1 PSer37 | phosphorylation down-regulates ⊣ | CTNNB1 | 19303846 | SIGNOR-227874 |
| NEK2 | phosphorylation up-regulates → | CTNNB1 PSer37 | phosphorylation down-regulates ⊣ | CTNNB1 | 30968157 | SIGNOR-278172 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-227901 |
| JNK | phosphorylation down-regulates | CTNNB1 | SIGNOR-187578 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-227889 |
| GSK3B | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-184785 |
| PRKCA | phosphorylation down-regulates | CTNNB1 | SIGNOR-278493 |
| GSK3B | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-116524 |
| GSK3B | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-141803 |
| JNK | phosphorylation down-regulates | CTNNB1 | SIGNOR-165026 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-227874 |
| NEK2 | phosphorylation → down-regulates quantity | CTNNB1 | SIGNOR-278172 |
