| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCZ | CTNNB1 | Ser675 | QDYKKRLsVELTSSL | phosphorylation down-regulates quantity by destabilization | 25660024 | SIGNOR-276880 |
| AURKA | CTNNB1 | Ser675 | QDYKKRLsVELTSSL | phosphorylation up-regulates quantity | 25217103 | SIGNOR-278469 |
| PAK4 | CTNNB1 | Ser675 | QDYKKRLsVELTSSL | phosphorylation up-regulates | 22173096 | SIGNOR-191557 |
| PRKACA | CTNNB1 | Ser675 | QDYKKRLsVELTSSL | phosphorylation up-regulates activity | 16476742 | SIGNOR-144482 |
| PAK1 | CTNNB1 | Ser675 | QDYKKRLsVELTSSL | phosphorylation up-regulates | 21822311 | SIGNOR-175944 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCZ | phosphorylation up-regulates → | CTNNB1 PSer675 | phosphorylation down-regulates ⊣ | CTNNB1 | 25660024 | SIGNOR-276880 |
| AURKA | phosphorylation up-regulates → | CTNNB1 PSer675 | phosphorylation up-regulates → | CTNNB1 | 25217103 | SIGNOR-278469 |
| PAK4 | phosphorylation up-regulates → | CTNNB1 PSer675 | phosphorylation up-regulates → | CTNNB1 | 22173096 | SIGNOR-191557 |
| PRKACA | phosphorylation up-regulates → | CTNNB1 PSer675 | phosphorylation up-regulates → | CTNNB1 | 16476742 | SIGNOR-144482 |
| PAK1 | phosphorylation up-regulates → | CTNNB1 PSer675 | phosphorylation up-regulates → | CTNNB1 | 21822311 | SIGNOR-175944 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCZ | phosphorylation down-regulates quantity by destabilization | CTNNB1 | SIGNOR-276880 |
| AURKA | phosphorylation → up-regulates quantity | CTNNB1 | SIGNOR-278469 |
| PAK4 | phosphorylation → up-regulates | CTNNB1 | SIGNOR-191557 |
| PRKACA | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-144482 |
| PAK1 | phosphorylation → up-regulates | CTNNB1 | SIGNOR-175944 |
