| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCZ | CTNNB1 | Ser552 | QDTQRRTsMGGTQQQ | phosphorylation down-regulates quantity by destabilization | 25660024 | SIGNOR-276879 |
| PRKACA | CTNNB1 | Ser552 | QDTQRRTsMGGTQQQ | phosphorylation up-regulates activity | 16476742 | SIGNOR-144478 |
| AKT1 | CTNNB1 | Ser552 | QDTQRRTsMGGTQQQ | phosphorylation up-regulates | 17287208 | SIGNOR-252499 |
| AKT | CTNNB1 | Ser552 | QDTQRRTsMGGTQQQ | phosphorylation up-regulates | 17287208 | SIGNOR-244222 |
| AURKA | CTNNB1 | Ser552 | QDTQRRTsMGGTQQQ | phosphorylation up-regulates quantity | 25217103 | SIGNOR-278468 |
| AKT2 | CTNNB1 | Ser552 | QDTQRRTsMGGTQQQ | phosphorylation up-regulates | 17287208 | SIGNOR-152958 |
| RPS6KA5 | CTNNB1 | Ser552 | QDTQRRTsMGGTQQQ | phosphorylation up-regulates activity | 27196759 | SIGNOR-278247 |
| CAMK2B | CTNNB1 | Ser552 | QDTQRRTsMGGTQQQ | phosphorylation down-regulates | 24117889 | SIGNOR-202825 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCZ | phosphorylation up-regulates → | CTNNB1 PSer552 | phosphorylation down-regulates ⊣ | CTNNB1 | 25660024 | SIGNOR-276879 |
| PRKACA | phosphorylation up-regulates → | CTNNB1 PSer552 | phosphorylation up-regulates → | CTNNB1 | 16476742 | SIGNOR-144478 |
| AKT1 | phosphorylation up-regulates → | CTNNB1 PSer552 | phosphorylation up-regulates → | CTNNB1 | 17287208 | SIGNOR-252499 |
| AKT | phosphorylation up-regulates → | CTNNB1 PSer552 | phosphorylation up-regulates → | CTNNB1 | 17287208 | SIGNOR-244222 |
| AURKA | phosphorylation up-regulates → | CTNNB1 PSer552 | phosphorylation up-regulates → | CTNNB1 | 25217103 | SIGNOR-278468 |
| AKT2 | phosphorylation up-regulates → | CTNNB1 PSer552 | phosphorylation up-regulates → | CTNNB1 | 17287208 | SIGNOR-152958 |
| RPS6KA5 | phosphorylation up-regulates → | CTNNB1 PSer552 | phosphorylation up-regulates → | CTNNB1 | 27196759 | SIGNOR-278247 |
| CAMK2B | phosphorylation up-regulates → | CTNNB1 PSer552 | phosphorylation down-regulates ⊣ | CTNNB1 | 24117889 | SIGNOR-202825 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCZ | phosphorylation down-regulates quantity by destabilization | CTNNB1 | SIGNOR-276879 |
| PRKACA | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-144478 |
| AKT1 | phosphorylation → up-regulates | CTNNB1 | SIGNOR-252499 |
| AKT | phosphorylation → up-regulates | CTNNB1 | SIGNOR-244222 |
| AURKA | phosphorylation → up-regulates quantity | CTNNB1 | SIGNOR-278468 |
| AKT2 | phosphorylation → up-regulates | CTNNB1 | SIGNOR-152958 |
| RPS6KA5 | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-278247 |
| CAMK2B | phosphorylation down-regulates | CTNNB1 | SIGNOR-202825 |
