| Name | PTPN7 |
| ID | P35236 |
| Role | phosphatase |
| Enzymatic Domains |
Tyrosine-protein phosphatase 97-350 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN7 | MAPK1 | – | dephosphorylation down-regulates | 10415025 | SIGNOR-69448 | |
| PTPN7 | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 10702794 | SIGNOR-248484 |
| PTPN7 | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 16226275 | SIGNOR-248483 |
| PTPN7 | MAPK14 | Tyr182 | TDDEMTGyVATRWYR | dephosphorylation down-regulates activity | 10206983 | SIGNOR-248485 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN7 | dephosphorylation down-regulates ⊣ | MAPK1 PTyr187 | dephosphorylation up-regulates → | MAPK1 | 10702794 | SIGNOR-248484 |
| PTPN7 | dephosphorylation down-regulates ⊣ | MAPK1 PTyr187 | dephosphorylation up-regulates → | MAPK1 | 16226275 | SIGNOR-248483 |
| PTPN7 | dephosphorylation down-regulates ⊣ | MAPK14 PTyr182 | dephosphorylation up-regulates → | MAPK14 | 10206983 | SIGNOR-248485 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN7 | dephosphorylation down-regulates | MAPK1 | SIGNOR-69448 |
| PTPN7 | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248484 |
| PTPN7 | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248483 |
| PTPN7 | dephosphorylation → down-regulates activity | MAPK14 | SIGNOR-248485 |