| Name | PTPN7 |
| ID | P35236 |
| Role | substrate |
| Enzymatic Domains |
Tyrosine-protein phosphatase 97-350 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | PTPN7 | Thr66 | EPICSVNtPREVTLH | phosphorylation up-regulates activity | 16226275 | SIGNOR-249476 |
| PRKACA | PTPN7 | Ser44 | RLQERRGsNVALMLD | phosphorylation down-regulates | 10559944 | SIGNOR-72147 |
| PRKACA | PTPN7 | – | phosphorylation down-regulates | 19047375 | SIGNOR-182522 | |
| MAPK14 | PTPN7 | Thr66 | EPICSVNtPREVTLH | phosphorylation down-regulates activity | 10206983 | SIGNOR-250110 |
| MAPK1 | PTPN7 | Thr66 | EPICSVNtPREVTLH | phosphorylation up-regulates activity | 16226275 | SIGNOR-249437 |
| PRKCD | PTPN7 | Ser246 | QYQEERRsVKHILFS | phosphorylation up-regulates activity | 16479000 | SIGNOR-276048 |
| PRKCH | PTPN7 | Ser246 | QYQEERRsVKHILFS | phosphorylation up-regulates activity | 16479000 | SIGNOR-276049 |
| MAPK1 | PTPN7 | Ser93 | ALQRQPPsPKQLEEE | phosphorylation up-regulates activity | 16226275 | SIGNOR-249436 |
| MAPK3 | PTPN7 | Ser93 | ALQRQPPsPKQLEEE | phosphorylation up-regulates activity | 16226275 | SIGNOR-249475 |
| Gbeta | PTPN7 | – | phosphorylation up-regulates activity | 16226275 | SIGNOR-270111 | |
| MAPK14 | PTPN7 | Ser93 | ALQRQPPsPKQLEEE | phosphorylation down-regulates activity | 10206983 | SIGNOR-250109 |
| ERK1/2 | PTPN7 | – | phosphorylation up-regulates activity | 16226275 | SIGNOR-270202 | |
| PRKCE | PTPN7 | Ser246 | QYQEERRsVKHILFS | phosphorylation up-regulates activity | 16479000 | SIGNOR-276050 |
| PRKD1 | PTPN7 | Ser246 | QYQEERRsVKHILFS | phosphorylation up-regulates activity | 16479000 | SIGNOR-276046 |
| PRKCQ | PTPN7 | Ser246 | QYQEERRsVKHILFS | phosphorylation up-regulates activity | 16479000 | SIGNOR-276045 |
| PRKCZ | PTPN7 | Ser246 | QYQEERRsVKHILFS | phosphorylation up-regulates activity | 16479000 | SIGNOR-276047 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | phosphorylation up-regulates → | PTPN7 PThr66 | phosphorylation up-regulates → | PTPN7 | 16226275 | SIGNOR-249476 |
| PRKACA | phosphorylation up-regulates → | PTPN7 PSer44 | phosphorylation down-regulates ⊣ | PTPN7 | 10559944 | SIGNOR-72147 |
| MAPK14 | phosphorylation up-regulates → | PTPN7 PThr66 | phosphorylation down-regulates ⊣ | PTPN7 | 10206983 | SIGNOR-250110 |
| MAPK1 | phosphorylation up-regulates → | PTPN7 PThr66 | phosphorylation up-regulates → | PTPN7 | 16226275 | SIGNOR-249437 |
| PRKCD | phosphorylation up-regulates → | PTPN7 PSer246 | phosphorylation up-regulates → | PTPN7 | 16479000 | SIGNOR-276048 |
| PRKCH | phosphorylation up-regulates → | PTPN7 PSer246 | phosphorylation up-regulates → | PTPN7 | 16479000 | SIGNOR-276049 |
| MAPK1 | phosphorylation up-regulates → | PTPN7 PSer93 | phosphorylation up-regulates → | PTPN7 | 16226275 | SIGNOR-249436 |
| MAPK3 | phosphorylation up-regulates → | PTPN7 PSer93 | phosphorylation up-regulates → | PTPN7 | 16226275 | SIGNOR-249475 |
| MAPK14 | phosphorylation up-regulates → | PTPN7 PSer93 | phosphorylation down-regulates ⊣ | PTPN7 | 10206983 | SIGNOR-250109 |
| PRKCE | phosphorylation up-regulates → | PTPN7 PSer246 | phosphorylation up-regulates → | PTPN7 | 16479000 | SIGNOR-276050 |
| PRKD1 | phosphorylation up-regulates → | PTPN7 PSer246 | phosphorylation up-regulates → | PTPN7 | 16479000 | SIGNOR-276046 |
| PRKCQ | phosphorylation up-regulates → | PTPN7 PSer246 | phosphorylation up-regulates → | PTPN7 | 16479000 | SIGNOR-276045 |
| PRKCZ | phosphorylation up-regulates → | PTPN7 PSer246 | phosphorylation up-regulates → | PTPN7 | 16479000 | SIGNOR-276047 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK3 | phosphorylation → up-regulates activity | PTPN7 | SIGNOR-249476 |
| PRKACA | phosphorylation down-regulates | PTPN7 | SIGNOR-72147 |
| PRKACA | phosphorylation down-regulates | PTPN7 | SIGNOR-182522 |
| MAPK14 | phosphorylation → down-regulates activity | PTPN7 | SIGNOR-250110 |
| MAPK1 | phosphorylation → up-regulates activity | PTPN7 | SIGNOR-249437 |
| PRKCD | phosphorylation → up-regulates activity | PTPN7 | SIGNOR-276048 |
| PRKCH | phosphorylation → up-regulates activity | PTPN7 | SIGNOR-276049 |
| MAPK1 | phosphorylation → up-regulates activity | PTPN7 | SIGNOR-249436 |
| MAPK3 | phosphorylation → up-regulates activity | PTPN7 | SIGNOR-249475 |
| Gbeta | phosphorylation → up-regulates activity | PTPN7 | SIGNOR-270111 |
| MAPK14 | phosphorylation → down-regulates activity | PTPN7 | SIGNOR-250109 |
| ERK1/2 | phosphorylation → up-regulates activity | PTPN7 | SIGNOR-270202 |
| PRKCE | phosphorylation → up-regulates activity | PTPN7 | SIGNOR-276050 |
| PRKD1 | phosphorylation → up-regulates activity | PTPN7 | SIGNOR-276046 |
| PRKCQ | phosphorylation → up-regulates activity | PTPN7 | SIGNOR-276045 |
| PRKCZ | phosphorylation → up-regulates activity | PTPN7 | SIGNOR-276047 |