| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK14 | PTPN7 | Thr66 | EPICSVNtPREVTLH | phosphorylation down-regulates activity | 10206983 | SIGNOR-250110 |
| MAPK1 | PTPN7 | Thr66 | EPICSVNtPREVTLH | phosphorylation up-regulates activity | 16226275 | SIGNOR-249437 |
| MAPK3 | PTPN7 | Thr66 | EPICSVNtPREVTLH | phosphorylation up-regulates activity | 16226275 | SIGNOR-249476 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK14 | phosphorylation up-regulates → | PTPN7 PThr66 | phosphorylation down-regulates ⊣ | PTPN7 | 10206983 | SIGNOR-250110 |
| MAPK1 | phosphorylation up-regulates → | PTPN7 PThr66 | phosphorylation up-regulates → | PTPN7 | 16226275 | SIGNOR-249437 |
| MAPK3 | phosphorylation up-regulates → | PTPN7 PThr66 | phosphorylation up-regulates → | PTPN7 | 16226275 | SIGNOR-249476 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK14 | phosphorylation → down-regulates activity | PTPN7 | SIGNOR-250110 |
| MAPK1 | phosphorylation → up-regulates activity | PTPN7 | SIGNOR-249437 |
| MAPK3 | phosphorylation → up-regulates activity | PTPN7 | SIGNOR-249476 |