| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCH | PTPN7 | Ser246 | QYQEERRsVKHILFS | phosphorylation up-regulates activity | 16479000 | SIGNOR-276049 |
| PRKCE | PTPN7 | Ser246 | QYQEERRsVKHILFS | phosphorylation up-regulates activity | 16479000 | SIGNOR-276050 |
| PRKD1 | PTPN7 | Ser246 | QYQEERRsVKHILFS | phosphorylation up-regulates activity | 16479000 | SIGNOR-276046 |
| PRKCQ | PTPN7 | Ser246 | QYQEERRsVKHILFS | phosphorylation up-regulates activity | 16479000 | SIGNOR-276045 |
| PRKCZ | PTPN7 | Ser246 | QYQEERRsVKHILFS | phosphorylation up-regulates activity | 16479000 | SIGNOR-276047 |
| PRKCD | PTPN7 | Ser246 | QYQEERRsVKHILFS | phosphorylation up-regulates activity | 16479000 | SIGNOR-276048 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCH | phosphorylation up-regulates → | PTPN7 PSer246 | phosphorylation up-regulates → | PTPN7 | 16479000 | SIGNOR-276049 |
| PRKCE | phosphorylation up-regulates → | PTPN7 PSer246 | phosphorylation up-regulates → | PTPN7 | 16479000 | SIGNOR-276050 |
| PRKD1 | phosphorylation up-regulates → | PTPN7 PSer246 | phosphorylation up-regulates → | PTPN7 | 16479000 | SIGNOR-276046 |
| PRKCQ | phosphorylation up-regulates → | PTPN7 PSer246 | phosphorylation up-regulates → | PTPN7 | 16479000 | SIGNOR-276045 |
| PRKCZ | phosphorylation up-regulates → | PTPN7 PSer246 | phosphorylation up-regulates → | PTPN7 | 16479000 | SIGNOR-276047 |
| PRKCD | phosphorylation up-regulates → | PTPN7 PSer246 | phosphorylation up-regulates → | PTPN7 | 16479000 | SIGNOR-276048 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCH | phosphorylation → up-regulates activity | PTPN7 | SIGNOR-276049 |
| PRKCE | phosphorylation → up-regulates activity | PTPN7 | SIGNOR-276050 |
| PRKD1 | phosphorylation → up-regulates activity | PTPN7 | SIGNOR-276046 |
| PRKCQ | phosphorylation → up-regulates activity | PTPN7 | SIGNOR-276045 |
| PRKCZ | phosphorylation → up-regulates activity | PTPN7 | SIGNOR-276047 |
| PRKCD | phosphorylation → up-regulates activity | PTPN7 | SIGNOR-276048 |