Entity Details

Name RDX
ID P35241
Role substrate
Enzymatic Domains
FERM 5-295
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
RHOARDXThr564AGRDKYKtLRQIRQGphosphorylation
up-regulates activity		35267019SIGNOR-268430
LRRK2RDX–phosphorylation
up-regulates activity		17447891SIGNOR-279203
ROCK1RDXThr573RQIRQGNtKQRIDEFphosphorylation
unknown		9456324SIGNOR-248995
ROCK1RDXThr564AGRDKYKtLRQIRQGphosphorylation
up-regulates activity		9456324SIGNOR-248994
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
RHOAphosphorylation
up-regulates
→
RDX
PThr564		phosphorylation
up-regulates
→		RDX35267019SIGNOR-268430
ROCK1phosphorylation
up-regulates
→
RDX
PThr573		phosphorylation
down-regulates
⊣		RDX9456324SIGNOR-248995
ROCK1phosphorylation
up-regulates
→
RDX
PThr564		phosphorylation
up-regulates
→		RDX9456324SIGNOR-248994
Regulator Mechanism/Effect Target SIGNOR-ID
RHOAphosphorylation
→
up-regulates activity 		RDXSIGNOR-268430
LRRK2phosphorylation
→
up-regulates activity 		RDXSIGNOR-279203
ROCK1phosphorylation
→
unknown 		RDXSIGNOR-248995
ROCK1phosphorylation
→
up-regulates activity 		RDXSIGNOR-248994