| Name | PTGS2 |
| ID | P35354 |
| Role | substrate |
| Enzymatic Domains |
EGF-like 18-55 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LYN | PTGS2 | Tyr120 | PPTYNADyGYKSWEA | phosphorylation up-regulates activity | 24970799 | SIGNOR-276643 |
| FYN | PTGS2 | Tyr446 | DQSRQMKyQSFNEYR | phosphorylation up-regulates activity | 24970799 | SIGNOR-276644 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LYN | phosphorylation up-regulates → | PTGS2 PTyr120 | phosphorylation up-regulates → | PTGS2 | 24970799 | SIGNOR-276643 |
| FYN | phosphorylation up-regulates → | PTGS2 PTyr446 | phosphorylation up-regulates → | PTGS2 | 24970799 | SIGNOR-276644 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| LYN | phosphorylation → up-regulates activity | PTGS2 | SIGNOR-276643 |
| FYN | phosphorylation → up-regulates activity | PTGS2 | SIGNOR-276644 |