| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK2A | HRH1 | Thr140 | LRYLKYRtKTRASAT | phosphorylation down-regulates | 15107581 | SIGNOR-124348 |
| CAMK2A | HRH1 | Ser398 | WKRLRSHsRQYVSGL | phosphorylation down-regulates | 15107581 | SIGNOR-124344 |
| PRKG1 | HRH1 | Ser398 | WKRLRSHsRQYVSGL | phosphorylation down-regulates | 15107581 | SIGNOR-124360 |
| PRKCA | HRH1 | Ser398 | WKRLRSHsRQYVSGL | phosphorylation down-regulates | 15107581 | SIGNOR-124352 |
| PRKCA | HRH1 | Thr478 | CNENFKKtFKRILHI | phosphorylation down-regulates | 15107581 | SIGNOR-124356 |
| PRKCA | HRH1 | Ser398 | WKRLRSHsRQYVSGL | phosphorylation down-regulates | 10101032 | SIGNOR-66015 |
| PRKG1 | HRH1 | Ser398 | WKRLRSHsRQYVSGL | phosphorylation down-regulates | 10101032 | SIGNOR-66019 |
| PRKACA | HRH1 | Ser398 | WKRLRSHsRQYVSGL | phosphorylation down-regulates | 15328002 | SIGNOR-128415 |
| PRKACA | HRH1 | Ser396 | FTWKRLRsHSRQYVS | phosphorylation down-regulates | 15328002 | SIGNOR-128411 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK2A | phosphorylation up-regulates → | HRH1 PThr140 | phosphorylation down-regulates ⊣ | HRH1 | 15107581 | SIGNOR-124348 |
| CAMK2A | phosphorylation up-regulates → | HRH1 PSer398 | phosphorylation down-regulates ⊣ | HRH1 | 15107581 | SIGNOR-124344 |
| PRKG1 | phosphorylation up-regulates → | HRH1 PSer398 | phosphorylation down-regulates ⊣ | HRH1 | 15107581 | SIGNOR-124360 |
| PRKCA | phosphorylation up-regulates → | HRH1 PSer398 | phosphorylation down-regulates ⊣ | HRH1 | 15107581 | SIGNOR-124352 |
| PRKCA | phosphorylation up-regulates → | HRH1 PThr478 | phosphorylation down-regulates ⊣ | HRH1 | 15107581 | SIGNOR-124356 |
| PRKCA | phosphorylation up-regulates → | HRH1 PSer398 | phosphorylation down-regulates ⊣ | HRH1 | 10101032 | SIGNOR-66015 |
| PRKG1 | phosphorylation up-regulates → | HRH1 PSer398 | phosphorylation down-regulates ⊣ | HRH1 | 10101032 | SIGNOR-66019 |
| PRKACA | phosphorylation up-regulates → | HRH1 PSer398 | phosphorylation down-regulates ⊣ | HRH1 | 15328002 | SIGNOR-128415 |
| PRKACA | phosphorylation up-regulates → | HRH1 PSer396 | phosphorylation down-regulates ⊣ | HRH1 | 15328002 | SIGNOR-128411 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CAMK2A | phosphorylation down-regulates | HRH1 | SIGNOR-124348 |
| CAMK2A | phosphorylation down-regulates | HRH1 | SIGNOR-124344 |
| PRKG1 | phosphorylation down-regulates | HRH1 | SIGNOR-124360 |
| PRKCA | phosphorylation down-regulates | HRH1 | SIGNOR-124352 |
| PRKCA | phosphorylation down-regulates | HRH1 | SIGNOR-124356 |
| PRKCA | phosphorylation down-regulates | HRH1 | SIGNOR-66015 |
| PRKG1 | phosphorylation down-regulates | HRH1 | SIGNOR-66019 |
| PRKACA | phosphorylation down-regulates | HRH1 | SIGNOR-128415 |
| PRKACA | phosphorylation down-regulates | HRH1 | SIGNOR-128411 |
