| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK2A | OPRM1 | Ser268 | LKSVRMLsGSKEKDR | phosphorylation down-regulates | 10908300 | SIGNOR-79678 |
| GRK3 | OPRM1 | Thr182 | VKALDFRtPRNAKII | phosphorylation down-regulates activity | 11060299 | SIGNOR-247915 |
| GRK2 | OPRM1 | Thr356 | FREFCIPtSSNIEQQ | phosphorylation down-regulates activity | 12123746 | SIGNOR-247782 |
| GRK2 | OPRM1 | Ser358 | EFCIPTSsNIEQQNS | phosphorylation down-regulates activity | 12123746 | SIGNOR-249661 |
| GRK2 | OPRM1 | Ser357 | REFCIPTsSNIEQQN | phosphorylation down-regulates activity | 12123746 | SIGNOR-251458 |
| CAMK2A | OPRM1 | Ser270 | SVRMLSGsKEKDRNL | phosphorylation down-regulates | 10908300 | SIGNOR-79682 |
| CAMK2A | OPRM1 | Thr372 | STRIRQNtRDHPSTA | phosphorylation down-regulates | 10908300 | SIGNOR-79686 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK2A | phosphorylation up-regulates → | OPRM1 PSer268 | phosphorylation down-regulates ⊣ | OPRM1 | 10908300 | SIGNOR-79678 |
| GRK3 | phosphorylation up-regulates → | OPRM1 PThr182 | phosphorylation down-regulates ⊣ | OPRM1 | 11060299 | SIGNOR-247915 |
| GRK2 | phosphorylation up-regulates → | OPRM1 PThr356 | phosphorylation down-regulates ⊣ | OPRM1 | 12123746 | SIGNOR-247782 |
| GRK2 | phosphorylation up-regulates → | OPRM1 PSer358 | phosphorylation down-regulates ⊣ | OPRM1 | 12123746 | SIGNOR-249661 |
| GRK2 | phosphorylation up-regulates → | OPRM1 PSer357 | phosphorylation down-regulates ⊣ | OPRM1 | 12123746 | SIGNOR-251458 |
| CAMK2A | phosphorylation up-regulates → | OPRM1 PSer270 | phosphorylation down-regulates ⊣ | OPRM1 | 10908300 | SIGNOR-79682 |
| CAMK2A | phosphorylation up-regulates → | OPRM1 PThr372 | phosphorylation down-regulates ⊣ | OPRM1 | 10908300 | SIGNOR-79686 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CAMK2A | phosphorylation down-regulates | OPRM1 | SIGNOR-79678 |
| GRK3 | phosphorylation → down-regulates activity | OPRM1 | SIGNOR-247915 |
| GRK2 | phosphorylation → down-regulates activity | OPRM1 | SIGNOR-247782 |
| GRK2 | phosphorylation → down-regulates activity | OPRM1 | SIGNOR-249661 |
| GRK2 | phosphorylation → down-regulates activity | OPRM1 | SIGNOR-251458 |
| CAMK2A | phosphorylation down-regulates | OPRM1 | SIGNOR-79682 |
| CAMK2A | phosphorylation down-regulates | OPRM1 | SIGNOR-79686 |
