| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GRK2 | OPRM1 | Ser358 | EFCIPTSsNIEQQNS | phosphorylation down-regulates activity | 12123746 | SIGNOR-249661 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GRK2 | phosphorylation up-regulates → | OPRM1 PSer358 | phosphorylation down-regulates ⊣ | OPRM1 | 12123746 | SIGNOR-249661 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GRK2 | phosphorylation → down-regulates activity | OPRM1 | SIGNOR-249661 |