| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GRK3 | OPRM1 | Thr182 | VKALDFRtPRNAKII | phosphorylation down-regulates activity | 11060299 | SIGNOR-247915 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GRK3 | phosphorylation up-regulates → | OPRM1 PThr182 | phosphorylation down-regulates ⊣ | OPRM1 | 11060299 | SIGNOR-247915 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GRK3 | phosphorylation → down-regulates activity | OPRM1 | SIGNOR-247915 |