Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PRKACA	ADD1	Ser408 View in OncoXplorer	REKSKKYsDVEVPAS	phosphorylation down-regulates activity	8810272	SIGNOR-250329
PRKCA	ADD1	Ser726 View in OncoXplorer	KKKFRTPsFLKKSKK	phosphorylation up-regulates	9679146	SIGNOR-59229
PRKACA	ADD1	Ser481 View in OncoXplorer	KEDGHRTsTSAVPNL	phosphorylation down-regulates activity	8810272	SIGNOR-250331
ROCK1	ADD1	Thr480 View in OncoXplorer	TKEDGHRtSTSAVPN	phosphorylation up-regulates	10209029	SIGNOR-66996
ROCK1	ADD1	Thr445	QKQQREKtRWLNSGR	phosphorylation up-regulates	10209029	SIGNOR-66992
PRKCZ	ADD1	Ser726 View in OncoXplorer	KKKFRTPsFLKKSKK	phosphorylation up-regulates	8810272	SIGNOR-43834
PRKACA	ADD1	Ser436 View in OncoXplorer	TCSPLRHsFQKQQRE	phosphorylation down-regulates activity	8810272	SIGNOR-250330
PRKCA	ADD1	Ser726 View in OncoXplorer	KKKFRTPsFLKKSKK	phosphorylation up-regulates	8810272	SIGNOR-43744
CDK5	ADD1	Thr724 View in OncoXplorer	KKKKKFRtPSFLKKS	phosphorylation up-regulates activity	31548578	SIGNOR-277487
PRKCZ	ADD1	Ser726 View in OncoXplorer	KKKFRTPsFLKKSKK	phosphorylation up-regulates	9679146	SIGNOR-59303

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PRKACA	phosphorylation up-regulates →	ADD1 PSer408	phosphorylation down-regulates ⊣	ADD1	8810272	SIGNOR-250329
PRKCA	phosphorylation up-regulates →	ADD1 PSer726	phosphorylation up-regulates →	ADD1	9679146	SIGNOR-59229
PRKACA	phosphorylation up-regulates →	ADD1 PSer481	phosphorylation down-regulates ⊣	ADD1	8810272	SIGNOR-250331
ROCK1	phosphorylation up-regulates →	ADD1 PThr480	phosphorylation up-regulates →	ADD1	10209029	SIGNOR-66996
ROCK1	phosphorylation up-regulates →	ADD1 PThr445	phosphorylation up-regulates →	ADD1	10209029	SIGNOR-66992
PRKCZ	phosphorylation up-regulates →	ADD1 PSer726	phosphorylation up-regulates →	ADD1	8810272	SIGNOR-43834
PRKACA	phosphorylation up-regulates →	ADD1 PSer436	phosphorylation down-regulates ⊣	ADD1	8810272	SIGNOR-250330
PRKCA	phosphorylation up-regulates →	ADD1 PSer726	phosphorylation up-regulates →	ADD1	8810272	SIGNOR-43744
CDK5	phosphorylation up-regulates →	ADD1 PThr724	phosphorylation up-regulates →	ADD1	31548578	SIGNOR-277487
PRKCZ	phosphorylation up-regulates →	ADD1 PSer726	phosphorylation up-regulates →	ADD1	9679146	SIGNOR-59303

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PRKACA	phosphorylation → down-regulates activity	ADD1	SIGNOR-250329
PRKCA	phosphorylation → up-regulates	ADD1	SIGNOR-59229
PRKACA	phosphorylation → down-regulates activity	ADD1	SIGNOR-250331
ROCK1	phosphorylation → up-regulates	ADD1	SIGNOR-66996
ROCK1	phosphorylation → up-regulates	ADD1	SIGNOR-66992
PRKCZ	phosphorylation → up-regulates	ADD1	SIGNOR-43834
PRKACA	phosphorylation → down-regulates activity	ADD1	SIGNOR-250330
PRKCA	phosphorylation → up-regulates	ADD1	SIGNOR-43744
CDK5	phosphorylation → up-regulates activity	ADD1	SIGNOR-277487
PRKCZ	phosphorylation → up-regulates	ADD1	SIGNOR-59303