| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | ADD2 | Ser713 | KKKFRTPsFLKKSKK | phosphorylation down-regulates | 16116087 | SIGNOR-139870 |
| PRKCD | ADD2 | Ser713 | KKKFRTPsFLKKSKK | phosphorylation unknown | 8810272 | SIGNOR-248952 |
| PRKCZ | ADD2 | Ser713 | KKKFRTPsFLKKSKK | phosphorylation down-regulates | 16116087 | SIGNOR-139914 |
| PRKCD | ADD2 | Ser726 | KKKEKVEs | phosphorylation unknown | 8810272 | SIGNOR-248953 |
| PRKACA | ADD2 | Ser713 | KKKFRTPsFLKKSKK | phosphorylation down-regulates activity | 8810272 | SIGNOR-250332 |
| PRKACA | ADD2 | Ser726 | KKKEKVEs | phosphorylation down-regulates activity | 8810272 | SIGNOR-250333 |
| PRKCA | ADD2 | Ser713 | KKKFRTPsFLKKSKK | phosphorylation down-regulates | 9679146 | SIGNOR-59299 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | phosphorylation up-regulates → | ADD2 PSer713 | phosphorylation down-regulates ⊣ | ADD2 | 16116087 | SIGNOR-139870 |
| PRKCD | phosphorylation up-regulates → | ADD2 PSer713 | phosphorylation down-regulates ⊣ | ADD2 | 8810272 | SIGNOR-248952 |
| PRKCZ | phosphorylation up-regulates → | ADD2 PSer713 | phosphorylation down-regulates ⊣ | ADD2 | 16116087 | SIGNOR-139914 |
| PRKCD | phosphorylation up-regulates → | ADD2 PSer726 | phosphorylation down-regulates ⊣ | ADD2 | 8810272 | SIGNOR-248953 |
| PRKACA | phosphorylation up-regulates → | ADD2 PSer713 | phosphorylation down-regulates ⊣ | ADD2 | 8810272 | SIGNOR-250332 |
| PRKACA | phosphorylation up-regulates → | ADD2 PSer726 | phosphorylation down-regulates ⊣ | ADD2 | 8810272 | SIGNOR-250333 |
| PRKCA | phosphorylation up-regulates → | ADD2 PSer713 | phosphorylation down-regulates ⊣ | ADD2 | 9679146 | SIGNOR-59299 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCA | phosphorylation down-regulates | ADD2 | SIGNOR-139870 |
| PRKCD | phosphorylation → unknown | ADD2 | SIGNOR-248952 |
| PRKCZ | phosphorylation down-regulates | ADD2 | SIGNOR-139914 |
| PRKCD | phosphorylation → unknown | ADD2 | SIGNOR-248953 |
| PRKACA | phosphorylation → down-regulates activity | ADD2 | SIGNOR-250332 |
| PRKACA | phosphorylation → down-regulates activity | ADD2 | SIGNOR-250333 |
| PRKCA | phosphorylation down-regulates | ADD2 | SIGNOR-59299 |
