| Name | GRK3 |
| ID | P35626 |
| Role | kinase |
| Enzymatic Domains |
RGS 54-175 PROSITE-ProRule
Protein kinase 191-453 PROSITE-ProRule
AGC-kinase C-terminal 454-521 PROSITE-ProRule
PH 558-652 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GRK3 | TBXA2R | Ser239 | AQQRPRDsEVEMMAQ | phosphorylation down-regulates activity | 16956790 | SIGNOR-274090 |
| GRK3 | TBXA2R | Ser357 | RLPGSSDsRASASRA | phosphorylation down-regulates activity | 16956790 | SIGNOR-274091 |
| GRK3 | BDKRB2 | Ser366 | EPIQMENsMGTLRTS | phosphorylation down-regulates activity | 11517230 | SIGNOR-251460 |
| GRK3 | BDKRB2 | Ser373 | SMGTLRTsISVERQI | phosphorylation down-regulates activity | 11517230 | SIGNOR-249658 |
| GRK3 | BDKRB2 | Ser375 | GTLRTSIsVERQIHK | phosphorylation down-regulates activity | 11517230 | SIGNOR-251462 |
| GRK3 | OPRM1 | Thr182 | VKALDFRtPRNAKII | phosphorylation down-regulates activity | 11060299 | SIGNOR-247915 |
| GRK3 | CCR5 | Ser336 | QEAPERAsSVYTRST | phosphorylation down-regulates activity | 10085131 | SIGNOR-251463 |
| GRK3 | CCR5 | Ser337 | EAPERASsVYTRSTG | phosphorylation down-regulates activity | 10085131 | SIGNOR-251464 |
| GRK3 | CCR5 | Ser342 | ASSVYTRsTGEQEIS | phosphorylation down-regulates activity | 10085131 | SIGNOR-249675 |
| GRK3 | CCR5 | Ser349 | STGEQEIsVGL | phosphorylation down-regulates activity | 10085131 | SIGNOR-249679 |
| GRK3 | C3AR1 | – | phosphorylation down-regulates activity | 21799898 | SIGNOR-279781 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GRK3 | phosphorylation up-regulates → | TBXA2R PSer239 | phosphorylation down-regulates ⊣ | TBXA2R | 16956790 | SIGNOR-274090 |
| GRK3 | phosphorylation up-regulates → | TBXA2R PSer357 | phosphorylation down-regulates ⊣ | TBXA2R | 16956790 | SIGNOR-274091 |
| GRK3 | phosphorylation up-regulates → | BDKRB2 PSer366 | phosphorylation down-regulates ⊣ | BDKRB2 | 11517230 | SIGNOR-251460 |
| GRK3 | phosphorylation up-regulates → | BDKRB2 PSer373 | phosphorylation down-regulates ⊣ | BDKRB2 | 11517230 | SIGNOR-249658 |
| GRK3 | phosphorylation up-regulates → | BDKRB2 PSer375 | phosphorylation down-regulates ⊣ | BDKRB2 | 11517230 | SIGNOR-251462 |
| GRK3 | phosphorylation up-regulates → | OPRM1 PThr182 | phosphorylation down-regulates ⊣ | OPRM1 | 11060299 | SIGNOR-247915 |
| GRK3 | phosphorylation up-regulates → | CCR5 PSer336 | phosphorylation down-regulates ⊣ | CCR5 | 10085131 | SIGNOR-251463 |
| GRK3 | phosphorylation up-regulates → | CCR5 PSer337 | phosphorylation down-regulates ⊣ | CCR5 | 10085131 | SIGNOR-251464 |
| GRK3 | phosphorylation up-regulates → | CCR5 PSer342 | phosphorylation down-regulates ⊣ | CCR5 | 10085131 | SIGNOR-249675 |
| GRK3 | phosphorylation up-regulates → | CCR5 PSer349 | phosphorylation down-regulates ⊣ | CCR5 | 10085131 | SIGNOR-249679 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GRK3 | phosphorylation → down-regulates activity | TBXA2R | SIGNOR-274090 |
| GRK3 | phosphorylation → down-regulates activity | TBXA2R | SIGNOR-274091 |
| GRK3 | phosphorylation → down-regulates activity | BDKRB2 | SIGNOR-251460 |
| GRK3 | phosphorylation → down-regulates activity | BDKRB2 | SIGNOR-249658 |
| GRK3 | phosphorylation → down-regulates activity | BDKRB2 | SIGNOR-251462 |
| GRK3 | phosphorylation → down-regulates activity | OPRM1 | SIGNOR-247915 |
| GRK3 | phosphorylation → down-regulates activity | CCR5 | SIGNOR-251463 |
| GRK3 | phosphorylation → down-regulates activity | CCR5 | SIGNOR-251464 |
| GRK3 | phosphorylation → down-regulates activity | CCR5 | SIGNOR-249675 |
| GRK3 | phosphorylation → down-regulates activity | CCR5 | SIGNOR-249679 |
| GRK3 | phosphorylation → down-regulates activity | C3AR1 | SIGNOR-279781 |