| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHKA | PLIN3 | Tyr251 | ERLRQHAyEHSLGKL | phosphorylation down-regulates quantity by destabilization | 34929314 | SIGNOR-267650 |
| CHKA | SRC | Tyr530 | FTSTEPQyQPGENL | phosphorylation down-regulates activity | 28784162 | SIGNOR-279731 |
| CHKA | CTNNB1 | – | phosphorylation down-regulates activity | 11818547 | SIGNOR-279161 | |
| CHKA | KDR | – | phosphorylation down-regulates quantity by destabilization | 22711876 | SIGNOR-279029 | |
| CHKA | MDM2 | – | phosphorylation down-regulates quantity by destabilization | 20708156 | SIGNOR-279606 | |
| CHKA | LPIN1 | – | phosphorylation down-regulates activity | 28049764 | SIGNOR-280228 | |
| CHKA | DEPTOR | Ser286 | SSMSSCGsSGYFSSS | phosphorylation down-regulates quantity by destabilization | 22017875 | SIGNOR-279604 |
| CHKA | DEPTOR | Ser287 | SMSSCGSsGYFSSSP | phosphorylation down-regulates quantity by destabilization | 22017875 | SIGNOR-279605 |
| CHKA | PLIN2 | Tyr232 | TKLHSRAyQQALSRV | phosphorylation down-regulates quantity by destabilization | 34929314 | SIGNOR-267649 |
| CHKA | TUT1 | – | phosphorylation up-regulates activity | 21729869 | SIGNOR-279162 | |
| CHKA | VANGL2 | – | phosphorylation down-regulates activity | 31090542 | SIGNOR-278925 | |
| CHKA | NCOA3 | – | phosphorylation down-regulates quantity by destabilization | 21577200 | SIGNOR-280229 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHKA | phosphorylation up-regulates → | PLIN3 PTyr251 | phosphorylation down-regulates ⊣ | PLIN3 | 34929314 | SIGNOR-267650 |
| CHKA | phosphorylation up-regulates → | SRC PTyr530 | phosphorylation down-regulates ⊣ | SRC | 28784162 | SIGNOR-279731 |
| CHKA | phosphorylation up-regulates → | DEPTOR PSer286 | phosphorylation down-regulates ⊣ | DEPTOR | 22017875 | SIGNOR-279604 |
| CHKA | phosphorylation up-regulates → | DEPTOR PSer287 | phosphorylation down-regulates ⊣ | DEPTOR | 22017875 | SIGNOR-279605 |
| CHKA | phosphorylation up-regulates → | PLIN2 PTyr232 | phosphorylation down-regulates ⊣ | PLIN2 | 34929314 | SIGNOR-267649 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CHKA | phosphorylation down-regulates quantity by destabilization | PLIN3 | SIGNOR-267650 |
| CHKA | phosphorylation → down-regulates activity | SRC | SIGNOR-279731 |
| CHKA | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-279161 |
| CHKA | phosphorylation down-regulates quantity by destabilization | KDR | SIGNOR-279029 |
| CHKA | phosphorylation down-regulates quantity by destabilization | MDM2 | SIGNOR-279606 |
| CHKA | phosphorylation → down-regulates activity | LPIN1 | SIGNOR-280228 |
| CHKA | phosphorylation down-regulates quantity by destabilization | DEPTOR | SIGNOR-279604 |
| CHKA | phosphorylation down-regulates quantity by destabilization | DEPTOR | SIGNOR-279605 |
| CHKA | phosphorylation down-regulates quantity by destabilization | PLIN2 | SIGNOR-267649 |
| CHKA | phosphorylation → up-regulates activity | TUT1 | SIGNOR-279162 |
| CHKA | phosphorylation → down-regulates activity | VANGL2 | SIGNOR-278925 |
| CHKA | phosphorylation down-regulates quantity by destabilization | NCOA3 | SIGNOR-280229 |
