Entity Details

Name CHKA
ID P35790
Role substrate
Enzymatic Domains
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
AMPKCHKASer279KKLHKLLsYNLPLELphosphorylation
up-regulates activity		34929314SIGNOR-267647
SRCCHKATyr197RSLGPKLyGIFPQGRphosphorylation
up-regulates activity		21822308SIGNOR-266351
ATRCHKA–phosphorylation
up-regulates activity		16085356SIGNOR-280184
SRCCHKATyr333LMLIDFEySSYNYRGphosphorylation
up-regulates activity		21822308SIGNOR-266350
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
AMPKphosphorylation
up-regulates
→
CHKA
PSer279		phosphorylation
up-regulates
→		CHKA34929314SIGNOR-267647
SRCphosphorylation
up-regulates
→
CHKA
PTyr197		phosphorylation
up-regulates
→		CHKA21822308SIGNOR-266351
SRCphosphorylation
up-regulates
→
CHKA
PTyr333		phosphorylation
up-regulates
→		CHKA21822308SIGNOR-266350
Regulator Mechanism/Effect Target SIGNOR-ID
AMPKphosphorylation
→
up-regulates activity 		CHKASIGNOR-267647
SRCphosphorylation
→
up-regulates activity 		CHKASIGNOR-266351
ATRphosphorylation
→
up-regulates activity 		CHKASIGNOR-280184
SRCphosphorylation
→
up-regulates activity 		CHKASIGNOR-266350