| Name | PPM1A |
| ID | P35813 |
| Role | phosphatase |
| Enzymatic Domains |
PPM-type phosphatase 23-291 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1A | IKBKB | Ser177 | AKELDQGsLCTSFVG | dephosphorylation down-regulates | 18930133 | SIGNOR-181655 |
| PPM1A | IKBKB | Ser181 | DQGSLCTsFVGTLQY | dephosphorylation down-regulates | 18930133 | SIGNOR-181659 |
| PPM1A | IKBKB | Ser177 | AKELDQGsLCTSFVG | dephosphorylation down-regulates activity | 18930133 | SIGNOR-248486 |
| PPM1A | IKBKB | Ser181 | DQGSLCTsFVGTLQY | dephosphorylation down-regulates activity | 18930133 | SIGNOR-248487 |
| PPM1A | AXIN1 | – | dephosphorylation down-regulates | 10644691 | SIGNOR-74231 | |
| PPM1A | AXIN1 | – | dephosphorylation down-regulates quantity by destabilization | 10644691 | SIGNOR-248488 | |
| PPM1A | CDK2 | – | dephosphorylation down-regulates activity | 10934208 | SIGNOR-277107 | |
| PPM1A | PIK3R1 | Ser608 | ENTEDQYsLVEDDED | dephosphorylation up-regulates activity | 15016818 | SIGNOR-248489 |
| PPM1A | YAP1 | Ser127 | PQHVRAHsSPASLQL | dephosphorylation up-regulates activity | 33630828 | SIGNOR-276984 |
| PPM1A | CDK9 | Thr186 | NSQPNRYtNRVVTLW | dephosphorylation down-regulates activity | 18829461 | SIGNOR-248490 |
| PPM1A | SMAD3 | – | dephosphorylation down-regulates | 16751101 | SIGNOR-146922 | |
| PPM1A | SMAD3 | – | dephosphorylation down-regulates activity | 16751101 | SIGNOR-232110 | |
| PPM1A | RELA | Ser276 | SMQLRRPsDRELSEP | dephosphorylation down-regulates activity | 23812431 | SIGNOR-276963 |
| PPM1A | RELA | Ser536 | SGDEDFSsIADMDFS | dephosphorylation down-regulates activity | 23812431 | SIGNOR-276964 |
| PPM1A | PAK1 | Ser199 | PRPEHTKsVYTRSVI | dephosphorylation down-regulates activity | 18586681 | SIGNOR-248492 |
| PPM1A | PAK1 | Ser57 | KKDRFYRsILPGDKT | dephosphorylation down-regulates activity | 18586681 | SIGNOR-248493 |
| PPM1A | PAK1 | Thr423 | PEQSKRStMVGTPYW | dephosphorylation down-regulates activity | 18586681 | SIGNOR-248491 |
| PPM1A | IKBKE | Ser172 | DDDEKFVsVYGTEEY | dephosphorylation down-regulates activity | 27419230 | SIGNOR-277072 |
| PPM1A | IRF3 | – | dephosphorylation down-regulates activity | 27419230 | SIGNOR-277152 | |
| PPM1A | SMAD2 | – | dephosphorylation down-regulates | 16751101 | SIGNOR-146919 | |
| PPM1A | SMAD2 | – | dephosphorylation down-regulates activity | 16751101 | SIGNOR-217628 | |
| PPM1A | SMAD2 | – | dephosphorylation down-regulates activity | 25026293 | SIGNOR-277034 | |
| PPM1A | SMAD1 | – | dephosphorylation down-regulates | 16931515 | SIGNOR-149077 | |
| PPM1A | MAPK14 | – | dephosphorylation down-regulates activity | 9707433 | SIGNOR-59618 | |
| PPM1A | STING1 | Ser358 | VPSTSTMsQEPELLI | dephosphorylation down-regulates activity | 25815785 | SIGNOR-276958 |
| PPM1A | TBK1 | Ser172 | EDDEQFVsLYGTEEY | dephosphorylation down-regulates activity | 27419230 | SIGNOR-276966 |
| PPM1A | GSK3B/Axin/APC | – | dephosphorylation down-regulates | 10644691 | SIGNOR-227955 | |
| PPM1A | PI3K | Ser608 | ENTEDQYsLVEDDED | dephosphorylation up-regulates activity | 15016818 | SIGNOR-252724 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1A | dephosphorylation down-regulates ⊣ | IKBKB PSer177 | dephosphorylation up-regulates → | IKBKB | 18930133 | SIGNOR-181655 |
| PPM1A | dephosphorylation down-regulates ⊣ | IKBKB PSer181 | dephosphorylation up-regulates → | IKBKB | 18930133 | SIGNOR-181659 |
| PPM1A | dephosphorylation down-regulates ⊣ | IKBKB PSer177 | dephosphorylation up-regulates → | IKBKB | 18930133 | SIGNOR-248486 |
| PPM1A | dephosphorylation down-regulates ⊣ | IKBKB PSer181 | dephosphorylation up-regulates → | IKBKB | 18930133 | SIGNOR-248487 |
| PPM1A | dephosphorylation down-regulates ⊣ | PIK3R1 PSer608 | dephosphorylation down-regulates ⊣ | PIK3R1 | 15016818 | SIGNOR-248489 |
| PPM1A | dephosphorylation down-regulates ⊣ | YAP1 PSer127 | dephosphorylation down-regulates ⊣ | YAP1 | 33630828 | SIGNOR-276984 |
| PPM1A | dephosphorylation down-regulates ⊣ | CDK9 PThr186 | dephosphorylation up-regulates → | CDK9 | 18829461 | SIGNOR-248490 |
| PPM1A | dephosphorylation down-regulates ⊣ | RELA PSer276 | dephosphorylation up-regulates → | RELA | 23812431 | SIGNOR-276963 |
| PPM1A | dephosphorylation down-regulates ⊣ | RELA PSer536 | dephosphorylation up-regulates → | RELA | 23812431 | SIGNOR-276964 |
| PPM1A | dephosphorylation down-regulates ⊣ | PAK1 PSer199 | dephosphorylation up-regulates → | PAK1 | 18586681 | SIGNOR-248492 |
| PPM1A | dephosphorylation down-regulates ⊣ | PAK1 PSer57 | dephosphorylation up-regulates → | PAK1 | 18586681 | SIGNOR-248493 |
| PPM1A | dephosphorylation down-regulates ⊣ | PAK1 PThr423 | dephosphorylation up-regulates → | PAK1 | 18586681 | SIGNOR-248491 |
| PPM1A | dephosphorylation down-regulates ⊣ | IKBKE PSer172 | dephosphorylation up-regulates → | IKBKE | 27419230 | SIGNOR-277072 |
| PPM1A | dephosphorylation down-regulates ⊣ | STING1 PSer358 | dephosphorylation up-regulates → | STING1 | 25815785 | SIGNOR-276958 |
| PPM1A | dephosphorylation down-regulates ⊣ | TBK1 PSer172 | dephosphorylation up-regulates → | TBK1 | 27419230 | SIGNOR-276966 |
| PPM1A | dephosphorylation down-regulates ⊣ | PI3K PSer608 | dephosphorylation down-regulates ⊣ | PI3K | 15016818 | SIGNOR-252724 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPM1A | dephosphorylation down-regulates | IKBKB | SIGNOR-181655 |
| PPM1A | dephosphorylation down-regulates | IKBKB | SIGNOR-181659 |
| PPM1A | dephosphorylation → down-regulates activity | IKBKB | SIGNOR-248486 |
| PPM1A | dephosphorylation → down-regulates activity | IKBKB | SIGNOR-248487 |
| PPM1A | dephosphorylation down-regulates | AXIN1 | SIGNOR-74231 |
| PPM1A | dephosphorylation down-regulates quantity by destabilization | AXIN1 | SIGNOR-248488 |
| PPM1A | dephosphorylation → down-regulates activity | CDK2 | SIGNOR-277107 |
| PPM1A | dephosphorylation → up-regulates activity | PIK3R1 | SIGNOR-248489 |
| PPM1A | dephosphorylation → up-regulates activity | YAP1 | SIGNOR-276984 |
| PPM1A | dephosphorylation → down-regulates activity | CDK9 | SIGNOR-248490 |
| PPM1A | dephosphorylation down-regulates | SMAD3 | SIGNOR-146922 |
| PPM1A | dephosphorylation → down-regulates activity | SMAD3 | SIGNOR-232110 |
| PPM1A | dephosphorylation → down-regulates activity | RELA | SIGNOR-276963 |
| PPM1A | dephosphorylation → down-regulates activity | RELA | SIGNOR-276964 |
| PPM1A | dephosphorylation → down-regulates activity | PAK1 | SIGNOR-248492 |
| PPM1A | dephosphorylation → down-regulates activity | PAK1 | SIGNOR-248493 |
| PPM1A | dephosphorylation → down-regulates activity | PAK1 | SIGNOR-248491 |
| PPM1A | dephosphorylation → down-regulates activity | IKBKE | SIGNOR-277072 |
| PPM1A | dephosphorylation → down-regulates activity | IRF3 | SIGNOR-277152 |
| PPM1A | dephosphorylation down-regulates | SMAD2 | SIGNOR-146919 |
| PPM1A | dephosphorylation → down-regulates activity | SMAD2 | SIGNOR-217628 |
| PPM1A | dephosphorylation → down-regulates activity | SMAD2 | SIGNOR-277034 |
| PPM1A | dephosphorylation down-regulates | SMAD1 | SIGNOR-149077 |
| PPM1A | dephosphorylation → down-regulates activity | MAPK14 | SIGNOR-59618 |
| PPM1A | dephosphorylation → down-regulates activity | STING1 | SIGNOR-276958 |
| PPM1A | dephosphorylation → down-regulates activity | TBK1 | SIGNOR-276966 |
| PPM1A | dephosphorylation down-regulates | GSK3B/Axin/APC | SIGNOR-227955 |
| PPM1A | dephosphorylation → up-regulates activity | PI3K | SIGNOR-252724 |