| Name | AHR |
| ID | P35869 |
| Role | substrate |
| Enzymatic Domains |
bHLH 27-80 PROSITE-ProRule
PAS 1 111-181 PROSITE-ProRule
PAS 2 275-342 PROSITE-ProRule
PAC 348-386 |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | AHR | Ser436 | LRTKNGTsGKDSATT | phosphorylation up-regulates activity | 34198826 | SIGNOR-276666 |
| GSK3B | AHR | Thr731 | FEPSPYPtTSSLEDF | phosphorylation up-regulates activity | 34198826 | SIGNOR-276665 |
| GSK3B | AHR | Ser440 | NGTSGKDsATTSTLS | phosphorylation up-regulates activity | 34198826 | SIGNOR-276662 |
| GSK3B | AHR | Ser689 | SQEFPYKsEMDSMPY | phosphorylation up-regulates activity | 34198826 | SIGNOR-276660 |
| GSK3B | AHR | Thr697 | EMDSMPYtQNFISCN | phosphorylation up-regulates activity | 34198826 | SIGNOR-276661 |
| GSK3B | AHR | Ser723 | ELDYPMGsFEPSPYP | phosphorylation up-regulates activity | 34198826 | SIGNOR-276658 |
| GSK3B | AHR | Ser727 | PMGSFEPsPYPTTSS | phosphorylation up-regulates activity | 34198826 | SIGNOR-276659 |
| GSK3B | AHR | Ser444 | GKDSATTsTLSKDSL | phosphorylation up-regulates activity | 34198826 | SIGNOR-276664 |
| GSK3B | AHR | Ser693 | PYKSEMDsMPYTQNF | phosphorylation up-regulates activity | 34198826 | SIGNOR-276663 |
| PLK1 | AHR | Ser489 | ENNFFNEsMNECRNW | phosphorylation down-regulates activity | 37988371 | SIGNOR-277885 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | AHR PSer436 | phosphorylation up-regulates → | AHR | 34198826 | SIGNOR-276666 |
| GSK3B | phosphorylation up-regulates → | AHR PThr731 | phosphorylation up-regulates → | AHR | 34198826 | SIGNOR-276665 |
| GSK3B | phosphorylation up-regulates → | AHR PSer440 | phosphorylation up-regulates → | AHR | 34198826 | SIGNOR-276662 |
| GSK3B | phosphorylation up-regulates → | AHR PSer689 | phosphorylation up-regulates → | AHR | 34198826 | SIGNOR-276660 |
| GSK3B | phosphorylation up-regulates → | AHR PThr697 | phosphorylation up-regulates → | AHR | 34198826 | SIGNOR-276661 |
| GSK3B | phosphorylation up-regulates → | AHR PSer723 | phosphorylation up-regulates → | AHR | 34198826 | SIGNOR-276658 |
| GSK3B | phosphorylation up-regulates → | AHR PSer727 | phosphorylation up-regulates → | AHR | 34198826 | SIGNOR-276659 |
| GSK3B | phosphorylation up-regulates → | AHR PSer444 | phosphorylation up-regulates → | AHR | 34198826 | SIGNOR-276664 |
| GSK3B | phosphorylation up-regulates → | AHR PSer693 | phosphorylation up-regulates → | AHR | 34198826 | SIGNOR-276663 |
| PLK1 | phosphorylation up-regulates → | AHR PSer489 | phosphorylation down-regulates ⊣ | AHR | 37988371 | SIGNOR-277885 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation → up-regulates activity | AHR | SIGNOR-276666 |
| GSK3B | phosphorylation → up-regulates activity | AHR | SIGNOR-276665 |
| GSK3B | phosphorylation → up-regulates activity | AHR | SIGNOR-276662 |
| GSK3B | phosphorylation → up-regulates activity | AHR | SIGNOR-276660 |
| GSK3B | phosphorylation → up-regulates activity | AHR | SIGNOR-276661 |
| GSK3B | phosphorylation → up-regulates activity | AHR | SIGNOR-276658 |
| GSK3B | phosphorylation → up-regulates activity | AHR | SIGNOR-276659 |
| GSK3B | phosphorylation → up-regulates activity | AHR | SIGNOR-276664 |
| GSK3B | phosphorylation → up-regulates activity | AHR | SIGNOR-276663 |
| PLK1 | phosphorylation → down-regulates activity | AHR | SIGNOR-277885 |