| Name | FLT4 |
| ID | P35916 |
| Role | kinase |
| Enzymatic Domains |
Ig-like C2-type 1 30-127
Ig-like C2-type 2 151-213
Ig-like C2-type 3 219-326
Ig-like C2-type 4 331-415
Ig-like C2-type 5 422-552
Ig-like C2-type 6 555-671
Ig-like C2-type 7 678-764
Protein kinase 845-1173 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FLT4 | SHC1 | Tyr349 | EEPPDHQyYNDFPGK | phosphorylation unknown | 9927207 | SIGNOR-64186 |
| FLT4 | SHC1 | Tyr350 | EPPDHQYyNDFPGKE | phosphorylation unknown | 9927207 | SIGNOR-64076 |
| FLT4 | SHC1 | Tyr427 | ELFDDPSyVNVQNLD | phosphorylation unknown | 9927207 | SIGNOR-64190 |
| FLT4 | FLT4 | Tyr1230 | RHSLAARyYNWVSFP | phosphorylation up-regulates activity | 12881528 | SIGNOR-104072 |
| FLT4 | FLT4 | Tyr1231 | HSLAARYyNWVSFPG | phosphorylation up-regulates activity | 12881528 | SIGNOR-104076 |
| FLT4 | FLT4 | Tyr1265 | FPMTPTTyKGSVDNQ | phosphorylation up-regulates activity | 12881528 | SIGNOR-104080 |
| FLT4 | FLT4 | Tyr1333 | ARGGQVFyNSEYGEL | phosphorylation up-regulates activity | 12881528 | SIGNOR-104084 |
| FLT4 | FLT4 | Tyr1337 | QVFYNSEyGELSEPS | phosphorylation up-regulates activity | 12881528 | SIGNOR-104088 |
| FLT4 | FLT4 | Tyr1363 | TFFTDNSy | phosphorylation up-regulates activity | 12881528 | SIGNOR-104092 |
| FLT4 | RPS6KA3 | Tyr707 | KGAMAATySALNRNQ | phosphorylation down-regulates | 12601080 | SIGNOR-98708 |
| FLT4 | GLO1 | Tyr136 | GIAVPDVySACKRFE | phosphorylation up-regulates activity | 34838714 | SIGNOR-276180 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FLT4 | phosphorylation up-regulates → | SHC1 PTyr349 | phosphorylation down-regulates ⊣ | SHC1 | 9927207 | SIGNOR-64186 |
| FLT4 | phosphorylation up-regulates → | SHC1 PTyr350 | phosphorylation down-regulates ⊣ | SHC1 | 9927207 | SIGNOR-64076 |
| FLT4 | phosphorylation up-regulates → | SHC1 PTyr427 | phosphorylation down-regulates ⊣ | SHC1 | 9927207 | SIGNOR-64190 |
| FLT4 | phosphorylation up-regulates → | FLT4 PTyr1230 | phosphorylation up-regulates → | FLT4 | 12881528 | SIGNOR-104072 |
| FLT4 | phosphorylation up-regulates → | FLT4 PTyr1231 | phosphorylation up-regulates → | FLT4 | 12881528 | SIGNOR-104076 |
| FLT4 | phosphorylation up-regulates → | FLT4 PTyr1265 | phosphorylation up-regulates → | FLT4 | 12881528 | SIGNOR-104080 |
| FLT4 | phosphorylation up-regulates → | FLT4 PTyr1333 | phosphorylation up-regulates → | FLT4 | 12881528 | SIGNOR-104084 |
| FLT4 | phosphorylation up-regulates → | FLT4 PTyr1337 | phosphorylation up-regulates → | FLT4 | 12881528 | SIGNOR-104088 |
| FLT4 | phosphorylation up-regulates → | FLT4 PTyr1363 | phosphorylation up-regulates → | FLT4 | 12881528 | SIGNOR-104092 |
| FLT4 | phosphorylation up-regulates → | RPS6KA3 PTyr707 | phosphorylation down-regulates ⊣ | RPS6KA3 | 12601080 | SIGNOR-98708 |
| FLT4 | phosphorylation up-regulates → | GLO1 PTyr136 | phosphorylation up-regulates → | GLO1 | 34838714 | SIGNOR-276180 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| FLT4 | phosphorylation → unknown | SHC1 | SIGNOR-64186 |
| FLT4 | phosphorylation → unknown | SHC1 | SIGNOR-64076 |
| FLT4 | phosphorylation → unknown | SHC1 | SIGNOR-64190 |
| FLT4 | phosphorylation → up-regulates activity | FLT4 | SIGNOR-104072 |
| FLT4 | phosphorylation → up-regulates activity | FLT4 | SIGNOR-104076 |
| FLT4 | phosphorylation → up-regulates activity | FLT4 | SIGNOR-104080 |
| FLT4 | phosphorylation → up-regulates activity | FLT4 | SIGNOR-104084 |
| FLT4 | phosphorylation → up-regulates activity | FLT4 | SIGNOR-104088 |
| FLT4 | phosphorylation → up-regulates activity | FLT4 | SIGNOR-104092 |
| FLT4 | phosphorylation down-regulates | RPS6KA3 | SIGNOR-98708 |
| FLT4 | phosphorylation → up-regulates activity | GLO1 | SIGNOR-276180 |