Entity Details

Name FLT4
ID P35916
Role substrate
Enzymatic Domains
Ig-like C2-type 1 30-127
Ig-like C2-type 2 151-213
Ig-like C2-type 3 219-326
Ig-like C2-type 4 331-415
Ig-like C2-type 5 422-552
Ig-like C2-type 6 555-671
Ig-like C2-type 7 678-764
Protein kinase 845-1173
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
SRCFLT4Tyr830PLEEQCEyLSYDASQphosphorylation
up-regulates		20431062SIGNOR-165047
FLT4FLT4Tyr1363TFFTDNSyphosphorylation
up-regulates activity		12881528SIGNOR-104092
FLT4FLT4Tyr1230RHSLAARyYNWVSFPphosphorylation
up-regulates activity		12881528SIGNOR-104072
SRCFLT4Tyr1333ARGGQVFyNSEYGELphosphorylation
up-regulates		20431062SIGNOR-165039
SRCFLT4Tyr1063FGLARDIyKDPDYVRphosphorylation
up-regulates		20431062SIGNOR-165035
FLT4FLT4Tyr1333ARGGQVFyNSEYGELphosphorylation
up-regulates activity		12881528SIGNOR-104084
FLT4FLT4Tyr1231HSLAARYyNWVSFPGphosphorylation
up-regulates activity		12881528SIGNOR-104076
SRCFLT4Tyr1337QVFYNSEyGELSEPSphosphorylation
up-regulates		20431062SIGNOR-165043
FLT4FLT4Tyr1337QVFYNSEyGELSEPSphosphorylation
up-regulates activity		12881528SIGNOR-104088
FLT4FLT4Tyr1265FPMTPTTyKGSVDNQphosphorylation
up-regulates activity		12881528SIGNOR-104080
SRCFLT4Tyr833EQCEYLSyDASQWEFphosphorylation
up-regulates		20431062SIGNOR-165051
SRCFLT4Tyr853HLGRVLGyGAFGKVVphosphorylation
up-regulates		20431062SIGNOR-165055
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
SRCphosphorylation
up-regulates
→
FLT4
PTyr830		phosphorylation
up-regulates
→		FLT420431062SIGNOR-165047
FLT4phosphorylation
up-regulates
→
FLT4
PTyr1363		phosphorylation
up-regulates
→		FLT412881528SIGNOR-104092
FLT4phosphorylation
up-regulates
→
FLT4
PTyr1230		phosphorylation
up-regulates
→		FLT412881528SIGNOR-104072
SRCphosphorylation
up-regulates
→
FLT4
PTyr1333		phosphorylation
up-regulates
→		FLT420431062SIGNOR-165039
SRCphosphorylation
up-regulates
→
FLT4
PTyr1063		phosphorylation
up-regulates
→		FLT420431062SIGNOR-165035
FLT4phosphorylation
up-regulates
→
FLT4
PTyr1333		phosphorylation
up-regulates
→		FLT412881528SIGNOR-104084
FLT4phosphorylation
up-regulates
→
FLT4
PTyr1231		phosphorylation
up-regulates
→		FLT412881528SIGNOR-104076
SRCphosphorylation
up-regulates
→
FLT4
PTyr1337		phosphorylation
up-regulates
→		FLT420431062SIGNOR-165043
FLT4phosphorylation
up-regulates
→
FLT4
PTyr1337		phosphorylation
up-regulates
→		FLT412881528SIGNOR-104088
FLT4phosphorylation
up-regulates
→
FLT4
PTyr1265		phosphorylation
up-regulates
→		FLT412881528SIGNOR-104080
SRCphosphorylation
up-regulates
→
FLT4
PTyr833		phosphorylation
up-regulates
→		FLT420431062SIGNOR-165051
SRCphosphorylation
up-regulates
→
FLT4
PTyr853		phosphorylation
up-regulates
→		FLT420431062SIGNOR-165055
Regulator Mechanism/Effect Target SIGNOR-ID
SRCphosphorylation
→
up-regulates 		FLT4SIGNOR-165047
FLT4phosphorylation
→
up-regulates activity 		FLT4SIGNOR-104092
FLT4phosphorylation
→
up-regulates activity 		FLT4SIGNOR-104072
SRCphosphorylation
→
up-regulates 		FLT4SIGNOR-165039
SRCphosphorylation
→
up-regulates 		FLT4SIGNOR-165035
FLT4phosphorylation
→
up-regulates activity 		FLT4SIGNOR-104084
FLT4phosphorylation
→
up-regulates activity 		FLT4SIGNOR-104076
SRCphosphorylation
→
up-regulates 		FLT4SIGNOR-165043
FLT4phosphorylation
→
up-regulates activity 		FLT4SIGNOR-104088
FLT4phosphorylation
→
up-regulates activity 		FLT4SIGNOR-104080
SRCphosphorylation
→
up-regulates 		FLT4SIGNOR-165051
SRCphosphorylation
→
up-regulates 		FLT4SIGNOR-165055