| Name | KDR |
| ID | P35968 |
| Role | substrate |
| Enzymatic Domains |
Ig-like C2-type 1 46-110
Ig-like C2-type 2 141-207
Ig-like C2-type 3 224-320
Ig-like C2-type 4 328-414
Ig-like C2-type 5 421-548
Ig-like C2-type 6 551-660
Ig-like C2-type 7 667-753
Protein kinase 834-1162 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK1D | KDR | – | phosphorylation down-regulates activity | 22711876 | SIGNOR-280235 | |
| KDR | KDR | Tyr1175 | AQQDGKDyIVLPISE | phosphorylation up-regulates | 17658244 | SIGNOR-157089 |
| KDR | KDR | Tyr951 | RFRQGKDyVGAIPVD | phosphorylation up-regulates | 17658244 | SIGNOR-157097 |
| KDR | KDR | Tyr1054 | FGLARDIyKDPDYVR | phosphorylation up-regulates | 17658244 | SIGNOR-157081 |
| PTPN2 | KDR | Tyr1214 | VCDPKFHyDNTAGIS | dephosphorylation down-regulates activity | 18840653 | SIGNOR-248401 |
| PTPN2 | KDR | Tyr1175 | AQQDGKDyIVLPISE | dephosphorylation down-regulates activity | 29955047 | SIGNOR-276961 |
| PTPN6 | KDR | Tyr1059 | DIYKDPDyVRKGDAR | dephosphorylation down-regulates activity | 18377662 | SIGNOR-248474 |
| PTPN1 | KDR | Tyr1175 | AQQDGKDyIVLPISE | dephosphorylation down-regulates activity | 23639442 | SIGNOR-277011 |
| PTPRG | KDR | Tyr1059 | DIYKDPDyVRKGDAR | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254708 |
| PTPRB | KDR | Tyr1175 | AQQDGKDyIVLPISE | dephosphorylation down-regulates activity | 19136612 | SIGNOR-248441 |
| PTPN2 | KDR | Tyr996 | EEAPEDLyKDFLTLE | dephosphorylation down-regulates | 18840653 | SIGNOR-181550 |
| PTPRJ | KDR | Tyr1059 | DIYKDPDyVRKGDAR | dephosphorylation down-regulates activity | 18936167 | SIGNOR-248710 |
| KDR | KDR | Tyr1214 | VCDPKFHyDNTAGIS | phosphorylation up-regulates | 17658244 | SIGNOR-157093 |
| PTPN2 | KDR | Tyr1059 | DIYKDPDyVRKGDAR | dephosphorylation down-regulates activity | 18840653 | SIGNOR-248400 |
| SRC | KDR | Tyr1175 | AQQDGKDyIVLPISE | phosphorylation up-regulates activity | 19050761 | SIGNOR-279120 |
| PTPN6 | KDR | Tyr996 | EEAPEDLyKDFLTLE | dephosphorylation unknown | 18840653 | SIGNOR-248476 |
| PTPN2 | KDR | Tyr996 | EEAPEDLyKDFLTLE | dephosphorylation unknown | 18840653 | SIGNOR-248398 |
| PTPN2 | KDR | Tyr1054 | FGLARDIyKDPDYVR | dephosphorylation down-regulates activity | 18840653 | SIGNOR-248399 |
| PTPRG | KDR | Tyr1054 | FGLARDIyKDPDYVR | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254707 |
| PTPN2 | KDR | Tyr1059 | DIYKDPDyVRKGDAR | dephosphorylation down-regulates activity | 29955047 | SIGNOR-276962 |
| KDR | KDR | Tyr996 | EEAPEDLyKDFLTLE | phosphorylation up-regulates | 10102632 | SIGNOR-66040 |
| KDR | KDR | Tyr1059 | DIYKDPDyVRKGDAR | phosphorylation up-regulates | 17658244 | SIGNOR-157085 |
| PTPRJ | KDR | Tyr1054 | FGLARDIyKDPDYVR | dephosphorylation down-regulates | 18936167 | SIGNOR-181672 |
| PTPRJ | KDR | Tyr1059 | DIYKDPDyVRKGDAR | dephosphorylation down-regulates | 18936167 | SIGNOR-181676 |
| PTPRJ | KDR | Tyr1054 | FGLARDIyKDPDYVR | dephosphorylation down-regulates activity | 18936167 | SIGNOR-248709 |
| PTPN2 | KDR | Tyr1214 | VCDPKFHyDNTAGIS | dephosphorylation down-regulates | 18840653 | SIGNOR-181546 |
| CHKA | KDR | – | phosphorylation down-regulates quantity by destabilization | 22711876 | SIGNOR-279029 | |
| PTPN6 | KDR | Tyr1175 | AQQDGKDyIVLPISE | dephosphorylation down-regulates activity | 18377662 | SIGNOR-248475 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| KDR | phosphorylation up-regulates → | KDR PTyr1175 | phosphorylation up-regulates → | KDR | 17658244 | SIGNOR-157089 |
| KDR | phosphorylation up-regulates → | KDR PTyr951 | phosphorylation up-regulates → | KDR | 17658244 | SIGNOR-157097 |
| KDR | phosphorylation up-regulates → | KDR PTyr1054 | phosphorylation up-regulates → | KDR | 17658244 | SIGNOR-157081 |
| PTPN2 | dephosphorylation down-regulates ⊣ | KDR PTyr1214 | dephosphorylation up-regulates → | KDR | 18840653 | SIGNOR-248401 |
| PTPN2 | dephosphorylation down-regulates ⊣ | KDR PTyr1175 | dephosphorylation up-regulates → | KDR | 29955047 | SIGNOR-276961 |
| PTPN6 | dephosphorylation down-regulates ⊣ | KDR PTyr1059 | dephosphorylation up-regulates → | KDR | 18377662 | SIGNOR-248474 |
| PTPN1 | dephosphorylation down-regulates ⊣ | KDR PTyr1175 | dephosphorylation up-regulates → | KDR | 23639442 | SIGNOR-277011 |
| PTPRG | dephosphorylation down-regulates ⊣ | KDR PTyr1059 | dephosphorylation up-regulates → | KDR | 25624455 | SIGNOR-254708 |
| PTPRB | dephosphorylation down-regulates ⊣ | KDR PTyr1175 | dephosphorylation up-regulates → | KDR | 19136612 | SIGNOR-248441 |
| PTPN2 | dephosphorylation down-regulates ⊣ | KDR PTyr996 | dephosphorylation up-regulates → | KDR | 18840653 | SIGNOR-181550 |
| PTPRJ | dephosphorylation down-regulates ⊣ | KDR PTyr1059 | dephosphorylation up-regulates → | KDR | 18936167 | SIGNOR-248710 |
| KDR | phosphorylation up-regulates → | KDR PTyr1214 | phosphorylation up-regulates → | KDR | 17658244 | SIGNOR-157093 |
| PTPN2 | dephosphorylation down-regulates ⊣ | KDR PTyr1059 | dephosphorylation up-regulates → | KDR | 18840653 | SIGNOR-248400 |
| SRC | phosphorylation up-regulates → | KDR PTyr1175 | phosphorylation up-regulates → | KDR | 19050761 | SIGNOR-279120 |
| PTPN6 | dephosphorylation down-regulates ⊣ | KDR PTyr996 | dephosphorylation up-regulates → | KDR | 18840653 | SIGNOR-248476 |
| PTPN2 | dephosphorylation down-regulates ⊣ | KDR PTyr996 | dephosphorylation up-regulates → | KDR | 18840653 | SIGNOR-248398 |
| PTPN2 | dephosphorylation down-regulates ⊣ | KDR PTyr1054 | dephosphorylation up-regulates → | KDR | 18840653 | SIGNOR-248399 |
| PTPRG | dephosphorylation down-regulates ⊣ | KDR PTyr1054 | dephosphorylation up-regulates → | KDR | 25624455 | SIGNOR-254707 |
| PTPN2 | dephosphorylation down-regulates ⊣ | KDR PTyr1059 | dephosphorylation up-regulates → | KDR | 29955047 | SIGNOR-276962 |
| KDR | phosphorylation up-regulates → | KDR PTyr996 | phosphorylation up-regulates → | KDR | 10102632 | SIGNOR-66040 |
| KDR | phosphorylation up-regulates → | KDR PTyr1059 | phosphorylation up-regulates → | KDR | 17658244 | SIGNOR-157085 |
| PTPRJ | dephosphorylation down-regulates ⊣ | KDR PTyr1054 | dephosphorylation up-regulates → | KDR | 18936167 | SIGNOR-181672 |
| PTPRJ | dephosphorylation down-regulates ⊣ | KDR PTyr1059 | dephosphorylation up-regulates → | KDR | 18936167 | SIGNOR-181676 |
| PTPRJ | dephosphorylation down-regulates ⊣ | KDR PTyr1054 | dephosphorylation up-regulates → | KDR | 18936167 | SIGNOR-248709 |
| PTPN2 | dephosphorylation down-regulates ⊣ | KDR PTyr1214 | dephosphorylation up-regulates → | KDR | 18840653 | SIGNOR-181546 |
| PTPN6 | dephosphorylation down-regulates ⊣ | KDR PTyr1175 | dephosphorylation up-regulates → | KDR | 18377662 | SIGNOR-248475 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK1D | phosphorylation → down-regulates activity | KDR | SIGNOR-280235 |
| KDR | phosphorylation → up-regulates | KDR | SIGNOR-157089 |
| KDR | phosphorylation → up-regulates | KDR | SIGNOR-157097 |
| KDR | phosphorylation → up-regulates | KDR | SIGNOR-157081 |
| PTPN2 | dephosphorylation → down-regulates activity | KDR | SIGNOR-248401 |
| PTPN2 | dephosphorylation → down-regulates activity | KDR | SIGNOR-276961 |
| PTPN6 | dephosphorylation → down-regulates activity | KDR | SIGNOR-248474 |
| PTPN1 | dephosphorylation → down-regulates activity | KDR | SIGNOR-277011 |
| PTPRG | dephosphorylation → down-regulates activity | KDR | SIGNOR-254708 |
| PTPRB | dephosphorylation → down-regulates activity | KDR | SIGNOR-248441 |
| PTPN2 | dephosphorylation down-regulates | KDR | SIGNOR-181550 |
| PTPRJ | dephosphorylation → down-regulates activity | KDR | SIGNOR-248710 |
| KDR | phosphorylation → up-regulates | KDR | SIGNOR-157093 |
| PTPN2 | dephosphorylation → down-regulates activity | KDR | SIGNOR-248400 |
| SRC | phosphorylation → up-regulates activity | KDR | SIGNOR-279120 |
| PTPN6 | dephosphorylation → unknown | KDR | SIGNOR-248476 |
| PTPN2 | dephosphorylation → unknown | KDR | SIGNOR-248398 |
| PTPN2 | dephosphorylation → down-regulates activity | KDR | SIGNOR-248399 |
| PTPRG | dephosphorylation → down-regulates activity | KDR | SIGNOR-254707 |
| PTPN2 | dephosphorylation → down-regulates activity | KDR | SIGNOR-276962 |
| KDR | phosphorylation → up-regulates | KDR | SIGNOR-66040 |
| KDR | phosphorylation → up-regulates | KDR | SIGNOR-157085 |
| PTPRJ | dephosphorylation down-regulates | KDR | SIGNOR-181672 |
| PTPRJ | dephosphorylation down-regulates | KDR | SIGNOR-181676 |
| PTPRJ | dephosphorylation → down-regulates activity | KDR | SIGNOR-248709 |
| PTPN2 | dephosphorylation down-regulates | KDR | SIGNOR-181546 |
| CHKA | phosphorylation down-regulates quantity by destabilization | KDR | SIGNOR-279029 |
| PTPN6 | dephosphorylation → down-regulates activity | KDR | SIGNOR-248475 |