Entity Details

Name PTPN1_Tyr1175
ID P35968
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PTPN6KDRTyr1175AQQDGKDyIVLPISEdephosphorylation
down-regulates activity		18377662SIGNOR-248475
KDRKDRTyr1175AQQDGKDyIVLPISEphosphorylation
up-regulates		17658244SIGNOR-157089
PTPN2KDRTyr1175AQQDGKDyIVLPISEdephosphorylation
down-regulates activity		29955047SIGNOR-276961
PTPRBKDRTyr1175AQQDGKDyIVLPISEdephosphorylation
down-regulates activity		19136612SIGNOR-248441
SRCKDRTyr1175AQQDGKDyIVLPISEphosphorylation
up-regulates activity		19050761SIGNOR-279120
PTPN1KDRTyr1175AQQDGKDyIVLPISEdephosphorylation
down-regulates activity		23639442SIGNOR-277011
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PTPN6dephosphorylation
down-regulates
⊣
KDR
PTyr1175		dephosphorylation
up-regulates
→		KDR18377662SIGNOR-248475
KDRphosphorylation
up-regulates
→
KDR
PTyr1175		phosphorylation
up-regulates
→		KDR17658244SIGNOR-157089
PTPN2dephosphorylation
down-regulates
⊣
KDR
PTyr1175		dephosphorylation
up-regulates
→		KDR29955047SIGNOR-276961
PTPRBdephosphorylation
down-regulates
⊣
KDR
PTyr1175		dephosphorylation
up-regulates
→		KDR19136612SIGNOR-248441
SRCphosphorylation
up-regulates
→
KDR
PTyr1175		phosphorylation
up-regulates
→		KDR19050761SIGNOR-279120
PTPN1dephosphorylation
down-regulates
⊣
KDR
PTyr1175		dephosphorylation
up-regulates
→		KDR23639442SIGNOR-277011
Regulator Mechanism/Effect Target SIGNOR-ID
PTPN6dephosphorylation
→
down-regulates activity 		KDRSIGNOR-248475
KDRphosphorylation
→
up-regulates 		KDRSIGNOR-157089
PTPN2dephosphorylation
→
down-regulates activity 		KDRSIGNOR-276961
PTPRBdephosphorylation
→
down-regulates activity 		KDRSIGNOR-248441
SRCphosphorylation
→
up-regulates activity 		KDRSIGNOR-279120
PTPN1dephosphorylation
→
down-regulates activity 		KDRSIGNOR-277011