| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| KDR | KDR | Tyr1054 | FGLARDIyKDPDYVR | phosphorylation up-regulates | 17658244 | SIGNOR-157081 |
| PTPN2 | KDR | Tyr1054 | FGLARDIyKDPDYVR | dephosphorylation down-regulates activity | 18840653 | SIGNOR-248399 |
| PTPRG | KDR | Tyr1054 | FGLARDIyKDPDYVR | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254707 |
| PTPRJ | KDR | Tyr1054 | FGLARDIyKDPDYVR | dephosphorylation down-regulates | 18936167 | SIGNOR-181672 |
| PTPRJ | KDR | Tyr1054 | FGLARDIyKDPDYVR | dephosphorylation down-regulates activity | 18936167 | SIGNOR-248709 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| KDR | phosphorylation up-regulates → | KDR PTyr1054 | phosphorylation up-regulates → | KDR | 17658244 | SIGNOR-157081 |
| PTPN2 | dephosphorylation down-regulates ⊣ | KDR PTyr1054 | dephosphorylation up-regulates → | KDR | 18840653 | SIGNOR-248399 |
| PTPRG | dephosphorylation down-regulates ⊣ | KDR PTyr1054 | dephosphorylation up-regulates → | KDR | 25624455 | SIGNOR-254707 |
| PTPRJ | dephosphorylation down-regulates ⊣ | KDR PTyr1054 | dephosphorylation up-regulates → | KDR | 18936167 | SIGNOR-181672 |
| PTPRJ | dephosphorylation down-regulates ⊣ | KDR PTyr1054 | dephosphorylation up-regulates → | KDR | 18936167 | SIGNOR-248709 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| KDR | phosphorylation → up-regulates | KDR | SIGNOR-157081 |
| PTPN2 | dephosphorylation → down-regulates activity | KDR | SIGNOR-248399 |
| PTPRG | dephosphorylation → down-regulates activity | KDR | SIGNOR-254707 |
| PTPRJ | dephosphorylation down-regulates | KDR | SIGNOR-181672 |
| PTPRJ | dephosphorylation → down-regulates activity | KDR | SIGNOR-248709 |
