| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN6 | KDR | Tyr1059 | DIYKDPDyVRKGDAR | dephosphorylation down-regulates activity | 18377662 | SIGNOR-248474 |
| PTPRG | KDR | Tyr1059 | DIYKDPDyVRKGDAR | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254708 |
| PTPN2 | KDR | Tyr1059 | DIYKDPDyVRKGDAR | dephosphorylation down-regulates activity | 18840653 | SIGNOR-248400 |
| PTPN2 | KDR | Tyr1059 | DIYKDPDyVRKGDAR | dephosphorylation down-regulates activity | 29955047 | SIGNOR-276962 |
| PTPRJ | KDR | Tyr1059 | DIYKDPDyVRKGDAR | dephosphorylation down-regulates activity | 18936167 | SIGNOR-248710 |
| KDR | KDR | Tyr1059 | DIYKDPDyVRKGDAR | phosphorylation up-regulates | 17658244 | SIGNOR-157085 |
| PTPRJ | KDR | Tyr1059 | DIYKDPDyVRKGDAR | dephosphorylation down-regulates | 18936167 | SIGNOR-181676 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN6 | dephosphorylation down-regulates ⊣ | KDR PTyr1059 | dephosphorylation up-regulates → | KDR | 18377662 | SIGNOR-248474 |
| PTPRG | dephosphorylation down-regulates ⊣ | KDR PTyr1059 | dephosphorylation up-regulates → | KDR | 25624455 | SIGNOR-254708 |
| PTPN2 | dephosphorylation down-regulates ⊣ | KDR PTyr1059 | dephosphorylation up-regulates → | KDR | 18840653 | SIGNOR-248400 |
| PTPN2 | dephosphorylation down-regulates ⊣ | KDR PTyr1059 | dephosphorylation up-regulates → | KDR | 29955047 | SIGNOR-276962 |
| PTPRJ | dephosphorylation down-regulates ⊣ | KDR PTyr1059 | dephosphorylation up-regulates → | KDR | 18936167 | SIGNOR-248710 |
| KDR | phosphorylation up-regulates → | KDR PTyr1059 | phosphorylation up-regulates → | KDR | 17658244 | SIGNOR-157085 |
| PTPRJ | dephosphorylation down-regulates ⊣ | KDR PTyr1059 | dephosphorylation up-regulates → | KDR | 18936167 | SIGNOR-181676 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN6 | dephosphorylation → down-regulates activity | KDR | SIGNOR-248474 |
| PTPRG | dephosphorylation → down-regulates activity | KDR | SIGNOR-254708 |
| PTPN2 | dephosphorylation → down-regulates activity | KDR | SIGNOR-248400 |
| PTPN2 | dephosphorylation → down-regulates activity | KDR | SIGNOR-276962 |
| PTPRJ | dephosphorylation → down-regulates activity | KDR | SIGNOR-248710 |
| KDR | phosphorylation → up-regulates | KDR | SIGNOR-157085 |
| PTPRJ | dephosphorylation down-regulates | KDR | SIGNOR-181676 |
