| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN2 | KDR | Tyr1214 | VCDPKFHyDNTAGIS | dephosphorylation down-regulates activity | 18840653 | SIGNOR-248401 |
| KDR | KDR | Tyr1214 | VCDPKFHyDNTAGIS | phosphorylation up-regulates | 17658244 | SIGNOR-157093 |
| PTPN2 | KDR | Tyr1214 | VCDPKFHyDNTAGIS | dephosphorylation down-regulates | 18840653 | SIGNOR-181546 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN2 | dephosphorylation down-regulates ⊣ | KDR PTyr1214 | dephosphorylation up-regulates → | KDR | 18840653 | SIGNOR-248401 |
| KDR | phosphorylation up-regulates → | KDR PTyr1214 | phosphorylation up-regulates → | KDR | 17658244 | SIGNOR-157093 |
| PTPN2 | dephosphorylation down-regulates ⊣ | KDR PTyr1214 | dephosphorylation up-regulates → | KDR | 18840653 | SIGNOR-181546 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN2 | dephosphorylation → down-regulates activity | KDR | SIGNOR-248401 |
| KDR | phosphorylation → up-regulates | KDR | SIGNOR-157093 |
| PTPN2 | dephosphorylation down-regulates | KDR | SIGNOR-181546 |
