| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN2 | KDR | Tyr996 | EEAPEDLyKDFLTLE | dephosphorylation down-regulates | 18840653 | SIGNOR-181550 |
| PTPN6 | KDR | Tyr996 | EEAPEDLyKDFLTLE | dephosphorylation unknown | 18840653 | SIGNOR-248476 |
| PTPN2 | KDR | Tyr996 | EEAPEDLyKDFLTLE | dephosphorylation unknown | 18840653 | SIGNOR-248398 |
| KDR | KDR | Tyr996 | EEAPEDLyKDFLTLE | phosphorylation up-regulates | 10102632 | SIGNOR-66040 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN2 | dephosphorylation down-regulates ⊣ | KDR PTyr996 | dephosphorylation up-regulates → | KDR | 18840653 | SIGNOR-181550 |
| PTPN6 | dephosphorylation down-regulates ⊣ | KDR PTyr996 | dephosphorylation up-regulates → | KDR | 18840653 | SIGNOR-248476 |
| PTPN2 | dephosphorylation down-regulates ⊣ | KDR PTyr996 | dephosphorylation up-regulates → | KDR | 18840653 | SIGNOR-248398 |
| KDR | phosphorylation up-regulates → | KDR PTyr996 | phosphorylation up-regulates → | KDR | 10102632 | SIGNOR-66040 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN2 | dephosphorylation down-regulates | KDR | SIGNOR-181550 |
| PTPN6 | dephosphorylation → unknown | KDR | SIGNOR-248476 |
| PTPN2 | dephosphorylation → unknown | KDR | SIGNOR-248398 |
| KDR | phosphorylation → up-regulates | KDR | SIGNOR-66040 |
