| Name | MAP2K2 |
| ID | P36507 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 72-369 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP2K2 | MAPK3 | Thr202 | HDHTGFLtEYVATRW | phosphorylation up-regulates | 1411546 | SIGNOR-19240 |
| MAP2K2 | MAPK3 | Tyr204 | HTGFLTEyVATRWYR | phosphorylation up-regulates | 1411546 | SIGNOR-19244 |
| MAP2K2 | MAPK3 | – | phosphorylation up-regulates activity | 11730323 | SIGNOR-258997 | |
| MAP2K2 | MAPK1 | Thr185 | HDHTGFLtEYVATRW | phosphorylation up-regulates | 11971971 | SIGNOR-86709 |
| MAP2K2 | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | phosphorylation up-regulates | 11971971 | SIGNOR-86713 |
| MAP2K2 | MAPK1 | – | phosphorylation up-regulates activity | 11730323 | SIGNOR-258996 | |
| MAP2K2 | CASP9 | Thr125 | PEVLRPEtPRPVDIG | phosphorylation down-regulates activity | 12792650 | SIGNOR-249386 |
| MAP2K2 | ERK1/2 | – | phosphorylation up-regulates | 11971971 | SIGNOR-244637 | |
| MAP2K2 | ERK1/2 | – | phosphorylation up-regulates activity | 11730323 | SIGNOR-258995 | |
| MAP2K2 | Gbeta | – | phosphorylation up-regulates | 1411546 | SIGNOR-269895 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP2K2 | phosphorylation up-regulates → | MAPK3 PThr202 | phosphorylation up-regulates → | MAPK3 | 1411546 | SIGNOR-19240 |
| MAP2K2 | phosphorylation up-regulates → | MAPK3 PTyr204 | phosphorylation up-regulates → | MAPK3 | 1411546 | SIGNOR-19244 |
| MAP2K2 | phosphorylation up-regulates → | MAPK1 PThr185 | phosphorylation up-regulates → | MAPK1 | 11971971 | SIGNOR-86709 |
| MAP2K2 | phosphorylation up-regulates → | MAPK1 PTyr187 | phosphorylation up-regulates → | MAPK1 | 11971971 | SIGNOR-86713 |
| MAP2K2 | phosphorylation up-regulates → | CASP9 PThr125 | phosphorylation down-regulates ⊣ | CASP9 | 12792650 | SIGNOR-249386 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAP2K2 | phosphorylation → up-regulates | MAPK3 | SIGNOR-19240 |
| MAP2K2 | phosphorylation → up-regulates | MAPK3 | SIGNOR-19244 |
| MAP2K2 | phosphorylation → up-regulates activity | MAPK3 | SIGNOR-258997 |
| MAP2K2 | phosphorylation → up-regulates | MAPK1 | SIGNOR-86709 |
| MAP2K2 | phosphorylation → up-regulates | MAPK1 | SIGNOR-86713 |
| MAP2K2 | phosphorylation → up-regulates activity | MAPK1 | SIGNOR-258996 |
| MAP2K2 | phosphorylation → down-regulates activity | CASP9 | SIGNOR-249386 |
| MAP2K2 | phosphorylation → up-regulates | ERK1/2 | SIGNOR-244637 |
| MAP2K2 | phosphorylation → up-regulates activity | ERK1/2 | SIGNOR-258995 |
| MAP2K2 | phosphorylation → up-regulates | Gbeta | SIGNOR-269895 |