| Name | MAP2K2 |
| ID | P36507 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 72-369 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CA | MAP2K2 | – | dephosphorylation down-regulates | 20626350 | SIGNOR-166652 | |
| RAF1 | MAP2K2 | Ser222 | VSGQLIDsMANSFVG | phosphorylation up-regulates | 8157000 | SIGNOR-262292 |
| ARAF | MAP2K2 | – | phosphorylation up-regulates | 21779497 | SIGNOR-175142 | |
| PDPK1 | MAP2K2 | Ser226 | LIDSMANsFVGTRSY | phosphorylation up-regulates | 15175348 | SIGNOR-125176 |
| MAP3K8 | MAP2K2 | Ser222 | VSGQLIDsMANSFVG | phosphorylation up-regulates | 15466476 | SIGNOR-129694 |
| RAF1 | MAP2K2 | Ser226 | LIDSMANsFVGTRSY | phosphorylation up-regulates | 8157000 | SIGNOR-36553 |
| BRAF | MAP2K2 | Ser226 | LIDSMANsFVGTRSY | phosphorylation up-regulates | 8668348 | SIGNOR-42668 |
| MAP3K8 | MAP2K2 | Ser226 | LIDSMANsFVGTRSY | phosphorylation up-regulates | 15466476 | SIGNOR-129698 |
| BRAF | MAP2K2 | Ser222 | VSGQLIDsMANSFVG | phosphorylation up-regulates | 8668348 | SIGNOR-42664 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RAF1 | phosphorylation up-regulates → | MAP2K2 PSer222 | phosphorylation up-regulates → | MAP2K2 | 8157000 | SIGNOR-262292 |
| PDPK1 | phosphorylation up-regulates → | MAP2K2 PSer226 | phosphorylation up-regulates → | MAP2K2 | 15175348 | SIGNOR-125176 |
| MAP3K8 | phosphorylation up-regulates → | MAP2K2 PSer222 | phosphorylation up-regulates → | MAP2K2 | 15466476 | SIGNOR-129694 |
| RAF1 | phosphorylation up-regulates → | MAP2K2 PSer226 | phosphorylation up-regulates → | MAP2K2 | 8157000 | SIGNOR-36553 |
| BRAF | phosphorylation up-regulates → | MAP2K2 PSer226 | phosphorylation up-regulates → | MAP2K2 | 8668348 | SIGNOR-42668 |
| MAP3K8 | phosphorylation up-regulates → | MAP2K2 PSer226 | phosphorylation up-regulates → | MAP2K2 | 15466476 | SIGNOR-129698 |
| BRAF | phosphorylation up-regulates → | MAP2K2 PSer222 | phosphorylation up-regulates → | MAP2K2 | 8668348 | SIGNOR-42664 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP2CA | dephosphorylation down-regulates | MAP2K2 | SIGNOR-166652 |
| RAF1 | phosphorylation → up-regulates | MAP2K2 | SIGNOR-262292 |
| ARAF | phosphorylation → up-regulates | MAP2K2 | SIGNOR-175142 |
| PDPK1 | phosphorylation → up-regulates | MAP2K2 | SIGNOR-125176 |
| MAP3K8 | phosphorylation → up-regulates | MAP2K2 | SIGNOR-129694 |
| RAF1 | phosphorylation → up-regulates | MAP2K2 | SIGNOR-36553 |
| BRAF | phosphorylation → up-regulates | MAP2K2 | SIGNOR-42668 |
| MAP3K8 | phosphorylation → up-regulates | MAP2K2 | SIGNOR-129698 |
| BRAF | phosphorylation → up-regulates | MAP2K2 | SIGNOR-42664 |