| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP3K8 | MAP2K2 | Ser222 | VSGQLIDsMANSFVG | phosphorylation up-regulates | 15466476 | SIGNOR-129694 |
| BRAF | MAP2K2 | Ser222 | VSGQLIDsMANSFVG | phosphorylation up-regulates | 8668348 | SIGNOR-42664 |
| RAF1 | MAP2K2 | Ser222 | VSGQLIDsMANSFVG | phosphorylation up-regulates | 8157000 | SIGNOR-262292 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP3K8 | phosphorylation up-regulates → | MAP2K2 PSer222 | phosphorylation up-regulates → | MAP2K2 | 15466476 | SIGNOR-129694 |
| BRAF | phosphorylation up-regulates → | MAP2K2 PSer222 | phosphorylation up-regulates → | MAP2K2 | 8668348 | SIGNOR-42664 |
| RAF1 | phosphorylation up-regulates → | MAP2K2 PSer222 | phosphorylation up-regulates → | MAP2K2 | 8157000 | SIGNOR-262292 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAP3K8 | phosphorylation → up-regulates | MAP2K2 | SIGNOR-129694 |
| BRAF | phosphorylation → up-regulates | MAP2K2 | SIGNOR-42664 |
| RAF1 | phosphorylation → up-regulates | MAP2K2 | SIGNOR-262292 |
