| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP1CC | AXIN1 | Ser217 | YTRTGSEsPKVCSDQ | dephosphorylation down-regulates activity | 17318175 | SIGNOR-248496 |
| PPP1CC | AXIN1 | Ser469 | AHEENPEsILDEHVQ | dephosphorylation down-regulates activity | 17318175 | SIGNOR-248497 |
| PPP1CC | AXIN1 | Ser75 | LGYEPEGsASPTPPY | dephosphorylation down-regulates activity | 17318175 | SIGNOR-248494 |
| PPP1CC | AXIN1 | Ser77 | YEPEGSAsPTPPYLK | dephosphorylation down-regulates activity | 17318175 | SIGNOR-248495 |
| PPP1CC | AHCYL1 | Ser68 | RSLSRSIsQSSTDSY | dephosphorylation unknown | 17635105 | SIGNOR-248498 |
| PPP1CC | DDX58 | Ser8 | MTTEQRRsLQAFQDY | dephosphorylation up-regulates activity | 23499489 | SIGNOR-264580 |
| PPP1CC | TP53 | Ser15 | PSVEPPLsQETFSDL | dephosphorylation down-regulates activity | 16501611 | SIGNOR-248499 |
| PPP1CC | TP53 | Ser37 | NVLSPLPsQAMDDLM | dephosphorylation down-regulates activity | 16501611 | SIGNOR-248500 |
| PPP1CC | EIF2S1 | – | dephosphorylation up-regulates activity | 27629041 | SIGNOR-254119 | |
| PPP1CC | NOS3 | Thr495 | TGITRKKtFKEVANA | dephosphorylation up-regulates activity | 19036824 | SIGNOR-248501 |
| PPP1CC | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 14633703 | SIGNOR-252605 |
| PPP1CC | TGFBR1 | – | dephosphorylation down-regulates | 14718519 | SIGNOR-121277 | |
| PPP1CC | CASP2 | Ser164 | STDTVEHsLDNKDGP | dephosphorylation up-regulates activity | 19531356 | SIGNOR-248503 |
| PPP1CC | CDK9 | Ser175 | FGLARAFsLAKNSQP | dephosphorylation up-regulates | 21533037 | SIGNOR-173450 |
| PPP1CC | CDK9 | Thr186 | NSQPNRYtNRVVTLW | dephosphorylation up-regulates | 21533037 | SIGNOR-173454 |
| PPP1CC | MDM2 | Ser370 | KKTIVNDsRESCVEE | dephosphorylation up-regulates quantity by stabilization | 23277204 | SIGNOR-248504 |
| PPP1CC | IKZF1 | – | dephosphorylation up-regulates | 21750978 | SIGNOR-174865 | |
| PPP1CC | IFIH1 | Ser88 | EALRRTGsPLAARYM | dephosphorylation up-regulates activity | 23499489 | SIGNOR-264579 |
| PPP1CC | IFIH1 | Ser88 | EALRRTGsPLAARYM | dephosphorylation up-regulates activity | 25865883 | SIGNOR-264578 |
| PPP1CC | AKT | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 14633703 | SIGNOR-248502 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP1CC | dephosphorylation down-regulates ⊣ | AXIN1 PSer217 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-248496 |
| PPP1CC | dephosphorylation down-regulates ⊣ | AXIN1 PSer469 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-248497 |
| PPP1CC | dephosphorylation down-regulates ⊣ | AXIN1 PSer75 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-248494 |
| PPP1CC | dephosphorylation down-regulates ⊣ | AXIN1 PSer77 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-248495 |
| PPP1CC | dephosphorylation down-regulates ⊣ | AHCYL1 PSer68 | dephosphorylation up-regulates → | AHCYL1 | 17635105 | SIGNOR-248498 |
| PPP1CC | dephosphorylation down-regulates ⊣ | DDX58 PSer8 | dephosphorylation down-regulates ⊣ | DDX58 | 23499489 | SIGNOR-264580 |
| PPP1CC | dephosphorylation down-regulates ⊣ | TP53 PSer15 | dephosphorylation up-regulates → | TP53 | 16501611 | SIGNOR-248499 |
| PPP1CC | dephosphorylation down-regulates ⊣ | TP53 PSer37 | dephosphorylation up-regulates → | TP53 | 16501611 | SIGNOR-248500 |
| PPP1CC | dephosphorylation down-regulates ⊣ | NOS3 PThr495 | dephosphorylation down-regulates ⊣ | NOS3 | 19036824 | SIGNOR-248501 |
| PPP1CC | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 14633703 | SIGNOR-252605 |
| PPP1CC | dephosphorylation down-regulates ⊣ | CASP2 PSer164 | dephosphorylation down-regulates ⊣ | CASP2 | 19531356 | SIGNOR-248503 |
| PPP1CC | dephosphorylation down-regulates ⊣ | CDK9 PSer175 | dephosphorylation down-regulates ⊣ | CDK9 | 21533037 | SIGNOR-173450 |
| PPP1CC | dephosphorylation down-regulates ⊣ | CDK9 PThr186 | dephosphorylation down-regulates ⊣ | CDK9 | 21533037 | SIGNOR-173454 |
| PPP1CC | dephosphorylation down-regulates ⊣ | MDM2 PSer370 | dephosphorylation down-regulates ⊣ | MDM2 | 23277204 | SIGNOR-248504 |
| PPP1CC | dephosphorylation down-regulates ⊣ | IFIH1 PSer88 | dephosphorylation down-regulates ⊣ | IFIH1 | 23499489 | SIGNOR-264579 |
| PPP1CC | dephosphorylation down-regulates ⊣ | IFIH1 PSer88 | dephosphorylation down-regulates ⊣ | IFIH1 | 25865883 | SIGNOR-264578 |
| PPP1CC | dephosphorylation down-regulates ⊣ | AKT PSer473 | dephosphorylation up-regulates → | AKT | 14633703 | SIGNOR-248502 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP1CC | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-248496 |
| PPP1CC | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-248497 |
| PPP1CC | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-248494 |
| PPP1CC | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-248495 |
| PPP1CC | dephosphorylation → unknown | AHCYL1 | SIGNOR-248498 |
| PPP1CC | dephosphorylation → up-regulates activity | DDX58 | SIGNOR-264580 |
| PPP1CC | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248499 |
| PPP1CC | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248500 |
| PPP1CC | dephosphorylation → up-regulates activity | EIF2S1 | SIGNOR-254119 |
| PPP1CC | dephosphorylation → up-regulates activity | NOS3 | SIGNOR-248501 |
| PPP1CC | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-252605 |
| PPP1CC | dephosphorylation down-regulates | TGFBR1 | SIGNOR-121277 |
| PPP1CC | dephosphorylation → up-regulates activity | CASP2 | SIGNOR-248503 |
| PPP1CC | dephosphorylation → up-regulates | CDK9 | SIGNOR-173450 |
| PPP1CC | dephosphorylation → up-regulates | CDK9 | SIGNOR-173454 |
| PPP1CC | dephosphorylation → up-regulates quantity by stabilization | MDM2 | SIGNOR-248504 |
| PPP1CC | dephosphorylation → up-regulates | IKZF1 | SIGNOR-174865 |
| PPP1CC | dephosphorylation → up-regulates activity | IFIH1 | SIGNOR-264579 |
| PPP1CC | dephosphorylation → up-regulates activity | IFIH1 | SIGNOR-264578 |
| PPP1CC | dephosphorylation → down-regulates activity | AKT | SIGNOR-248502 |
