Entity Details

Name ACVR1B
ID P36896
Role kinase
Enzymatic Domains
GS 177-206
PROSITE-ProRule
Protein kinase 207-497
PROSITE-ProRule
View in

Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
ACVR1BTDP2Thr88PKTYVDLtNEETTDSphosphorylation
up-regulates activity		18039968SIGNOR-262611
ACVR1BTDP2Thr92VDLTNEEtTDSTTSKphosphorylation
up-regulates activity		18039968SIGNOR-262612
ACVR1BSMAD3–phosphorylation
up-regulates activity		14517293SIGNOR-235160
ACVR1BSMAD2–phosphorylation
up-regulates activity		11389842SIGNOR-251943
ACVR1BSMAD2–phosphorylation
up-regulates activity		14517293SIGNOR-235157
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
ACVR1Bphosphorylation
up-regulates
→
TDP2
PThr88		phosphorylation
up-regulates
→		TDP218039968SIGNOR-262611
ACVR1Bphosphorylation
up-regulates
→
TDP2
PThr92		phosphorylation
up-regulates
→		TDP218039968SIGNOR-262612
Regulator Mechanism/Effect Target SIGNOR-ID
ACVR1Bphosphorylation
→
up-regulates activity 		TDP2SIGNOR-262611
ACVR1Bphosphorylation
→
up-regulates activity 		TDP2SIGNOR-262612
ACVR1Bphosphorylation
→
up-regulates activity 		SMAD3SIGNOR-235160
ACVR1Bphosphorylation
→
up-regulates activity 		SMAD2SIGNOR-251943
ACVR1Bphosphorylation
→
up-regulates activity 		SMAD2SIGNOR-235157